A5038408124- Vaccine Coverage and Hesitancy
- Hematological disorders and diagnostics
- Streptococcal Infections and Treatments
- Respiratory viral infections research
- Viral Infections and Vectors
- Rabies epidemiology and control
- Patient-Provider Communication in Healthcare
- COVID-19 Impact on Reproduction
- COVID-19 and Mental Health
- Thermal Regulation in Medicine
- Inflammasome and immune disorders
- Long-Term Effects of COVID-19
- Vector-borne infectious diseases
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- Ethics and Legal Issues in Pediatric Healthcare
- Neurological diseases and metabolism
- Bartonella species infections research
- Otolaryngology and Infectious Diseases
- Clinical Reasoning and Diagnostic Skills
- Enterobacteriaceae and Cronobacter Research
- Simulation-Based Education in Healthcare
- Virology and Viral Diseases
- Adolescent and Pediatric Healthcare
- Reliability and Agreement in Measurement
University of Louisville
2014-2025
Kosair Children's Hospital
2020-2025
Norton Healthcare
2023
Norton Hospital
2020-2021
Abstract Background Diagnostic test evaluation requires a reference standard. We describe an approach for creating standard acute infection using unrestricted adjudication and apply it to compare biomarker tools. Methods Adults children with suspected enrolled in three prospective studies at emergency departments urgent cares were included. Adjudicators, blinded C-reactive protein, procalcitonin, MeMed BV (MMBV), labeled each case (bacterial/viral/non-infectious/indeterminate). Initial...
Isavuconazole, administered as the water-soluble prodrug isavuconazonium sulfate, is a new triazole agent used to treat invasive fungal infections. This phase 1 study evaluated pharmacokinetics (PK), safety, and tolerability of isavuconazole in 46 immunocompromised pediatric patients, stratified by age (1 <6 [intravenous (i.v.) only], 6 <12, 12 <18 years), receiving 10 mg/kg body weight (maximum, 372 mg) sulfate either i.v. or orally.
<title>Abstract</title> <bold>Background: </bold>There are no accepted best practices for counseling vaccine-hesitant parents, and targeted training in this area is not required during residency, despite widespread vaccine hesitancy among parents. In a prior study, we demonstrated that in-person structured communication strategy called AIMS (Announce-Inquire-Mirror-Secure) resulted learned behaviors live encounters with standardized patients (SPs) portraying <bold>Objective: </bold>Determine...
Patient-level data on the clinical features and outcomes of children young people referred for possible long coronavirus disease (COVID) can guide clinicians what to expect in managing patients advising families.A Post-Acute COVID Clinic persons <21 years age was established October 2020. Intake standardized management tailored presenting symptoms. Data were abstracted from charts all evaluated through December 2021, study cohort consisted who had a history confirmed severe acute respiratory...
Older case series established diagnostic considerations for children meeting a priori definitions of fever unknown origin (FUO). No recent study has examined the final diagnoses referred unexplained fever. This was conducted with retrospective chart review patients to pediatric infectious diseases clinic from 2008 2012 Sixty-nine 221 were "prolonged" Ten these not actually having fever, and 11 had that readily apparent at initial visit. The remaining 48 classified as FUO. median duration...
Abstract The coronavirus disease 2019 (COVID-19) pandemic has created many challenges for pediatric solid organ transplant (SOT) recipients and their families. As the persists, patients families struggle to identify best safest practices resuming activities as areas reopen. Notably, decisions about returning school remain difficult. We assembled a team of infectious diseases (ID), ID, public health, psychology, infection prevention control specialists address primary concerns reentry SOT in...
In the Southern Hemisphere 2010 influenza season, Seqirus' split-virion, trivalent inactivated vaccine was associated with increased reports of fevers and febrile reactions in young children. A staged clinical development program a quadrivalent (Seqirus IIV4 [S-IIV4]; Afluria® Quadrivalent/Afluria Quad™/Afluria Tetra™), wherein each strain is split using higher detergent concentration to reduce lipid content (considered cause reactions), now complete. Children aged 6–59 months were...
The Advisory Committee on Immunization Practices (ACIP) recommends additional immunizations for people with asplenia or functional asplenia, such as children sickle cell disease. Adherence rate to the recommended immunization schedule remains low purpose of this study was assess adherence population at a single institution in Kentucky and evaluate use Registry (KYIR) by providers.A single-center retrospective chart review conducted 107 disease ages 2 through 18 years. histories were obtained...
Abstract The COVID-19 pandemic continues to generate challenges for pediatric solid organ transplant (SOT) recipients and their families. As rates of fluctuate, new SARS-CoV-2 variants emerge, adherence implementation mitigation strategies vary from community community, questions remain about the best safest practices prevent in vulnerable patients. Notably, decisions returning school difficult. We assembled a team specialists infectious diseases, public health, psychology, infection...
The mother of a 5-week-old term infant brings the to pediatrician’s office, along with plastic milk bottle used feed baby. has splotches red-pink material on inside (Fig. 1). She wants know what is happening in bottle. been breastfeeding and recently transitioning pumped breast preparation for returning work. For past few days, she noticed that remaining bottles were left sink overnight after evening feedings turns bright pink by morning. normal color during pumping, pump tubing, stored...
A 5-month-old previously healthy female presented with a one-week history of fever and increased fussiness. Her presentation revealed an ill-appearing infant exam cerebrospinal fluid (CSF) studies concerning bacterial meningitis; CSF cultures grew Pasteurella multocida. Additionally, brain magnetic resonance imaging (MRI) demonstrated cervical osteomyelitis. Despite multiple days antibiotic therapy, she remained febrile continued pain; MRI showed oligoarticular effusions, aspiration these...
Abstract A telephone interview was conducted with parents of 120 children seen in a pediatric infectious diseases clinic for unexplained fever who received no definitive diagnosis or were thought to have recurrent self-limited illnesses. Only 3 diagnosed fever-related condition after 8 years follow-up. The majority remained well.
Unexplained fever is a common reason for outpatient referral to pediatric infectious diseases (PID) subspecialists. A previous study at our center concluded that most children referred PID prolonged or recurrent unexplained have self-limited illnesses and receive no specific diagnosis. Studies looking long-term outcomes of such patients not been published. The cohort consisted 156 seen in the clinic from 2008 through 2012 who were given definitive diagnosis thought sequential illnesses, plus...
Abstract Background Vaccine hesitancy (VH) is one of the top 10 threats to global public health. While VH common among parents, there are no accepted best practices for counseling, and training in this area not required residency. Strategies needed help providers address practice. Methods The AIMS (Announce, Inquire, Mirror, Secure) Method Healthy Conversations a structured communication strategy that attempts build trust between provider patient (or parent), inviting receptivity healthcare...