A5035536314- Photochromic and Fluorescence Chemistry
- Radical Photochemical Reactions
- Photopolymerization techniques and applications
- Lipid metabolism and biosynthesis
- Crystallization and Solubility Studies
- Photochemistry and Electron Transfer Studies
- X-ray Diffraction in Crystallography
- Luminescence and Fluorescent Materials
- Dyeing and Modifying Textile Fibers
- Photosynthetic Processes and Mechanisms
- Photoreceptor and optogenetics research
- Peroxisome Proliferator-Activated Receptors
Iowa State University
2019-2021
A robust lipophilic dye, based on the structures of benzothiadiazole heterocycle, was shown to be a potent fluorescent stain for selective imaging lipid droplets (LDs) within both live and fixed human cells. Its small molecular framework, large Stokes shift, vastly improved photostability over that current status quo, Nile Red, highlight its tremendous potential as versatile chemical tool facilitating LD research.
A new class of push–pull dyes based on the reactive isobenzofuran core have been synthesized. The a smaller HOMO–LUMO gap than related benzofurazan and allow for isolation structural factors that contribute to environmental sensitivity. Experimental theoretical evidence implicate different photophysical processes are responsible reversal emissive behavior is observed between analogues.
An unexpected nucleophilic aromatic substitution lead to a novel benzothiadiazole scaffold that bore the functional group pattern associated with benzyl-type photocleavable protecting groups. The new molecules display efficient photochemical release of leaving groups blue light. performance both ortho- and meta-substituted derivatives was probed through structural manipulation computational metrics improve performance.
A novel lipophilic dye, based on the structures of benzothiadiazole heterocycles, was shown to be an effective fluorescent stain for imaging lipid droplets (LDs) within both fixed and live cells. Its high photo stability, large Stokes shift, improved staining specificity over that commercial dye Nile Red highlight its great potential as a versatile chemical tool facilitating LD research.
A novel lipophilic dye, based on the structures of benzothiadiazole heterocycles, was shown to be an effective fluorescent stain for imaging lipid droplets (LDs) within both fixed and live cells. Its high photo stability, large Stokes shift, improved staining specificity over that commercial dye Nile Red highlight its great potential as a versatile chemical tool facilitating LD research.
<p>A strategy to control the efficiency of a photocleavage reaction based on changing nature excited state is presented. A novel class photoactive compounds has been synthesized by combining classical o-nitrobenzyl scaffold with an environmentally sensitive dye, 4-amino-nitrobenzothiazole. Irradiation in polar solvent lead that inoperative for photochemistry whereas excitation nonpolar photochemically active. photochemical degradation appears be preferred process contrast intended...
A strategy to control the efficiency of a photocleavage reaction based on changing nature excited state is presented. novel class photoactive compounds has been synthesized by combining classical o-nitrobenzyl scaffold with an environmentally sensitive dye, 4-amino-nitrobenzothiazole. Irradiation in polar solvent lead that inoperative for photochemistry whereas excitation nonpolar photochemically active. photochemical degradation appears be preferred process contrast intended process.
Abstract A new design strategy to control the efficiency of a photocleavage reaction based on changing nature excited state is presented. novel class photoactive compounds has been synthesized by combining classical o ‐nitrobenzyl scaffold with an environmentally sensitive dye, 4‐amino‐nitrobenzothiazole. Irradiation in polar solvent led that was inoperative for photochemistry whereas excitation nonpolar photochemically active. While our hypothesis tests true on/off photochemical process,...