A5065386912- Neurogenesis and neuroplasticity mechanisms
- Pluripotent Stem Cells Research
- Developmental Biology and Gene Regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Axon Guidance and Neuronal Signaling
- Neonatal and fetal brain pathology
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Glioma Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
- Hedgehog Signaling Pathway Studies
Yunnan Yingmao Biotechnology (China)
2023-2024
Kunming University of Science and Technology
2023-2024
University of Basel
2017-2019
Neurogenesis continues in the ventricular-subventricular zone (V-SVZ) of adult forebrain from quiescent neural stem cells (NSCs). V-SVZ NSCs are a reservoir for new olfactory bulb (OB) neurons that migrate through rostral migratory stream (RMS). To generate neurons, need to activate and enter cell cycle. The mechanisms underlying NSC transition quiescence activity poorly understood. We show Notch2, but not Notch1, signaling conveys by repressing cell-cycle-related genes neurogenesis. Loss...
Neural stem cells (NSCs) in the adult mouse hippocampal dentate gyrus (DG) are mostly quiescent, and only a few cell cycle at any point time. DG NSCs become increasingly dormant with age enter mitosis less frequently, which impinges on neurogenesis. How NSC inactivity is maintained largely unknown. Here, we found that Id4 downstream target of Notch2 signaling maintains quiescence by blocking cell-cycle entry. expression sufficient to promote knockdown rescues Notch2-induced inhibition...
While accumulated publications support the existence of neurogenesis in adult human hippocampus, homeostasis and developmental potentials neural stem cells (NSCs) under different contexts remain unclear. Based on our generated single-nucleus atlas hippocampus across neonatal, adult, aging, injury, we dissected molecular heterogeneity transcriptional dynamics hippocampal NSCs contexts. We further identified new specific neurogenic lineage markers that overcome lack specificity found some...
While accumulated publications support the existence of neurogenesis in adult human hippocampus, homeostasis and developmental potentials neural stem cells (NSCs) under different contexts remain unclear. Based on our generated single-nucleus atlas hippocampus across neonatal, adult, aging injury, we dissected molecular heterogeneity transcriptional dynamics hippocampal NSCs contexts. We further identified new specific neurogenic lineage markers that overcome lack specificity found some...
While accumulated publications support the existence of neurogenesis in adult human hippocampus, homeostasis and developmental potentials neural stem cells (NSCs) under different contexts remain unclear. Based on our generated single-nucleus atlas hippocampus across neonatal, adult, aging, injury, we dissected molecular heterogeneity transcriptional dynamics hippocampal NSCs contexts. We further identified new specific neurogenic lineage markers that overcome lack specificity found some...
While accumulated publications support the existence of neurogenesis in adult human hippocampus, homeostasis and developmental potentials neural stem cells (NSCs) under different contexts remain unclear. Based on our generated single-nucleus atlas hippocampus across neonatal, adult, aging injury, we dissected molecular heterogeneity transcriptional dynamics hippocampal NSCs contexts. We further identified new specific neurogenic lineage markers that overcome lack specificity found some...
While accumulated publications support the existence of neurogenesis in adult human hippocampus, homeostasis and developmental potentials neural stem cells (NSCs) under different contexts remain unclear. Based on our generated single-nucleus atlas hippocampus across neonatal, adult, aging injury, we dissected molecular heterogeneity transcriptional dynamics hippocampal NSCs contexts. We further identified new specific neurogenic lineage markers that overcome lack specificity found some...
Neural stem cells (NSCs) in the adult hippocampal dentate gyrus (DG) can be quiescent or proliferative, but how they are maintained is largely unknown. With age DG NSCs become increasingly dormant, which impinges on neuron generation. We addressed NSC activity controlled and found that Notch2 promotes quiescence by regulating their transition to activated state. Notch2-ablation induces cell cycle genes markers of active NSCs. Conversely, NSC-associated genes, including Id4, down regulated...
Summary Neural stem cells (NSCs) in the adult hippocampal dentate gyrus (DG) can be quiescent or proliferative, but how they are maintained is largely unknown. With age DG NSCs become increasingly dormant, which impinges on neuron generation. We addressed NSC activity controlled and found that Notch2 promotes quiescence by regulating their transition to activated state. -ablation induces cell cycle genes markers of active NSCs. Conversely, NSC-associated genes, including Id4 , down regulated...
Abstract While accumulated publications support the existence of neurogenesis in adult human hippocampus, homeostasis and developmental potentials neural stem cells (NSCs) under different contexts remain unclear. Based on our generated single-nucleus atlas hippocampus across neonatal, adult, aging injury, we dissected molecular heterogeneity transcriptional dynamics hippocampal NSCs contexts. We further identified new specific neurogenic lineage markers that overcome lack specificity found...