A5101587849- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Bacterial Genetics and Biotechnology
- DNA Repair Mechanisms
- Insect-Plant Interactions and Control
- Monoclonal and Polyclonal Antibodies Research
- Tree Root and Stability Studies
- Agricultural pest management studies
- Insect Resistance and Genetics
- Receptor Mechanisms and Signaling
- Cancer therapeutics and mechanisms
- Rangeland and Wildlife Management
- Ecology and Vegetation Dynamics Studies
- Genomics and Phylogenetic Studies
Indian Institute of Science Bangalore
2021-2024
Loughborough University
1998
1. Growth performance of six plant species early successional communities was studied on three landslide-damaged sites varying ages (3-, 6- and 8-year-old), in the Central Himalaya. 2. The were equally divided among trees, shrubs herbs. Of these, two nodule forming (Alnus nepalensis, a tree species, Desmodium tilaefolium, shrub species). 3. results indicated that suitable mixture around A. nepalensis can be developed to hasten revegetation process bare sites. 4. is suggested as principal for...
Initiation factor 3 (IF3) regulates the fidelity of bacterial translation initiation by debarring use non-canonical start codons or non-initiator tRNAs and prevents premature docking 50S ribosomal subunit to 30S pre-initiation complex (PIC). The C-terminal domain (CTD) IF3 can carry out most known functions sustain Escherichia coli growth. However, roles N-terminal (NTD) have remained unclear. We hypothesized that interaction between NTD initiator tRNAfMet (i-tRNA) is essential coordinate...
Lamotrigine (Ltg), an anticonvulsant drug, targets initiation factor 2 (IF2), compromises ribosome biogenesis and causes toxicity to Escherichia coli. However, our understanding of Ltg in E. coli remains unclear. While vitro assays reveal no effects on the ribosome-dependent GTPase activity IF2 or its role as measured by dipeptide formation a fast kinetics assay, vivo experiments show that accumulation 17S precursor 16S rRNA leads decrease polysome levels overexpression increases toxicity....
Abstract The anticodon stem of initiator tRNA (i‐tRNA) possesses the characteristic three consecutive GC base pairs (G29:C41, G30:C40, and G31:C39 abbreviated as GC/GC/GC or 3GC pairs) crucial to commencing translation. To understand importance this highly conserved element, we isolated two fast‐growing suppressors Escherichia coli sustained solely on an unconventional i‐tRNA (i‐tRNA cg/GC/cg ) having sequence instead conventional GC/GC/GC. Both have common mutation V93A in initiation factor...
RsgA (small ribosomal subunit, 30S, GTPase), a late-stage biogenesis factor, releases RbfA from 30S-RbfA complex.