A5058079746- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Chemical synthesis and alkaloids
- Microbial Natural Products and Biosynthesis
- Enzyme Catalysis and Immobilization
- Magnetism in coordination complexes
- Metal-Organic Frameworks: Synthesis and Applications
- Chemical Synthesis and Analysis
- Lanthanide and Transition Metal Complexes
- Microbial Metabolism and Applications
- Alkaloids: synthesis and pharmacology
- Biochemical and Structural Characterization
- Synthesis of Indole Derivatives
- Cyclopropane Reaction Mechanisms
- Microbial Metabolic Engineering and Bioproduction
- Catalytic Cross-Coupling Reactions
- Marine Toxins and Detection Methods
University of Michigan
2019-2024
Washtenaw Community College
2021
Clarkson University
2015-2017
The prototypical single-molecule magnet (SMM) molecule [Mn12O12(O2CCH3)16(OH2)4] was incorporated under mild conditions into a highly porous metal–organic framework (MOF) matrix as proof of principle for controlled nanostructuring SMMs. Four independent experiments revealed that the SMM clusters were successfully loaded in MOF pores, namely synchrotron-based powder diffraction, physisorption analysis, and in-depth magnetic thermal analyses. results provide incontrovertible evidence...
Selective access to a targeted isomer is often critical in the synthesis of biologically active molecules. Whereas small-molecule reagents and catalysts act with anticipated site- stereoselectivity, this predictability does not extend enzymes. Further, lack that provide complementary selectivity creates challenge application biocatalysis synthesis. Here, we report an approach for accessing biocatalysts orthogonal protein engineering. Through use sequence similarity network (SSN), number...
Achieving substrate-selectivity is a central element of nature's approach to synthesis. By relying on the ability catalyst discriminate between components in mixture, control can be exerted over which molecules will move forward This powerful when realized but challenging duplicate laboratory. In this work, substrate-selective catalysis leveraged two intermediates that exist equilibrium, subsequently directing final cyclization arrive at either linear or angular tricyclic core common subsets...
Secondary metabolites are assembled by enzymes that often perform reactions with high selectivity and specificity. Many of these also tolerate variations in substrate structure, exhibiting promiscuity enables various applications a given biocatalyst. However, initial enzyme characterization studies frequently do not explore beyond the native substrates. This limited assessment scope contributes to difficulty identifying appropriate for specific synthetic applications. Here, we report natural...
Seven new zwitterionic metal-organic frameworks (ZW MOFs) of compositions {[Cd(L1)(OH2)]·2H2O}n (1), {[Mn(L1)(OH2)2]·H2O}n (2), {[Cu(HL1)2(OH2)3]·9H2O}n (3), {[Mn2(L2)2(OH2)4]·3H2O}n (4), [Co(L2)(OH2)4]·H2O (5), [Ni(L2)(OH2)3]n (6), and {[Cd(L2)(OH2)3]·4H2O}n (7), where H3L1Br = 3-carboxy-1-(3,5-dicarboxybenzyl)pyridinium bromide H3L2Br 4-carboxy-1-(3,5-dicarboxybenzyl)pyridinium bromide, have been synthesized under hydrothermal conditions. We demonstrate that the diversity these crystal...
Achieving substrate-selectivity is a central element of nature’s approach to synthesis; relying on the ability catalyst discriminate, based small structural changes, which molecules will move forward in synthesis. This can be challenging duplicate laboratory, but powerful when realized. In this work, substrate-selective catalysis leveraged discriminate between two intermediates that exist equilibrium, subsequently directing final cyclization arrive at either linear or angular tricyclic core...