A5061857531- Advanced Drug Delivery Systems
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Natural product bioactivities and synthesis
- Drug Solubulity and Delivery Systems
- Layered Double Hydroxides Synthesis and Applications
- Drug Transport and Resistance Mechanisms
- Flavonoids in Medical Research
- Silicone and Siloxane Chemistry
- Pharmacological Effects of Natural Compounds
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Electrospun Nanofibers in Biomedical Applications
- Polyoxometalates: Synthesis and Applications
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Sirtuins and Resveratrol in Medicine
- Phytochemistry and Biological Activities
- Cancer, Lipids, and Metabolism
- Polymer Surface Interaction Studies
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Autophagy in Disease and Therapy
- Crystallization and Solubility Studies
- Advancements in Transdermal Drug Delivery
Guizhou University
2023-2024
China Pharmaceutical University
2015-2024
Chinese PLA General Hospital
2016-2023
Chinese Academy of Sciences
2022
Kunming Institute of Botany
2022
Capital University
2020
Capital Medical University
2020
Jinzhou Medical University
2020
Hubei University of Arts and Science
2019
Xiangyang Central Hospital
2019
A self‐adjusting, blood vessel‐mimicking, multilayered tubular structure with two polymers, poly(ε‐caprolactone) (PCL) and poly( dl ‐lactide‐ co ‐glycolide) (PLGA), can keep the shape of scaffold during biodegradation. The inner layer tube expand whereas outer (PLGA) layers will shrink to maintain stability space both in vitro vivo over months. This approach be generally useful for making scaffolds that require maintenance a defined shape, based on FDA‐approved materials.
The objective of the study was to prepare solid dispersions containing a thermally unstable drug by hot-melt extrusion (HME). Carbamazepine (CBZ) selected as model and combinations Kollidon VA64 (VA64), Soluplus (SOL) Eudragit EPO (EPO) were utilized carriers. Preformulation conducted identify suitability polymer based on solubility parameters, differential scanning calorimetry (DSC), hot stage microscopy thermogravimetric analysis. Physicochemical properties determined DSC, X-ray...
The purposes of this study were to expand the structure parent drugs selected for peptide transporter 1 (PepT1)-targeted ester prodrug design and improve oral bioavailability oleanolic acid (OA), a Biopharmaceutics Classification System (BCS) class IV drug. Through an ethoxy linker carboxylic group OA was conjugated with different amino promoieties form six diester prodrugs. effective permeability (P(eff)) prodrugs screened by in situ rat single-pass intestinal perfusion (SPIP) model two...
By taking advantage of the cytotoxic effect nitric oxide (NO) and PepT1 for molecule-targeted drug delivery, a series amino acid/dipeptide diester prodrugs NO-donating oleanolic acid derivatives were designed synthesized. Two 6a 8a showed potent cytotoxcity, which is probably due to their high affinity NO-releasing ability. Furthermore, aqueous solubility was also significantly enhanced because hydrophilic promoiety.
To achieve efficient drug delivery to the posterior segment of eye via topical instillation, novel multifunctional nanocomposites were prepared by hybridizing dexamethasone disodium phosphate (DEXP)-loaded liposome (LP) glycylsarcosine (GS)-anchored layered double hydroxides (named DEXP-HSPC@LDH-GS) and then fully characterized. The exhibited sustained-release performance as well prolonged precorneal retention ability. MTT assays showed that not cytotoxic both human corneal epithelial cells...
To enhance ocular bioavailability, the traditional strategies have focused on prolonging precorneal retention and improving corneal permeability by nano-carriers with positive charge, thiolated polymer, absorption enhancer so on. Glycylsarcosine (GS) as an active target ligand of peptide tranpsporter-1 (PepT-1), could specific interact PepT-1 cornea guide nanoparticles to treating site.The objective study was explore targeting intercalated nanocomposites based...
Abstract: To study the cellular uptake mechanism of multifunctional organic–inorganic hybrid nanoparticles and nanosheets, new chitosan–glutathione–valine–valine-layered double hydroxide (CG-VV-LDH) nanosheets with active targeting to peptide transporter-1 (PepT-1) were prepared, characterized further compared CG-VV-LDH nanoparticles. Both showed a sustained release in vitro prolonged precorneal retention time vivo, but superior permeability isolated cornea rabbits than nanosheets....
Gemcitabine (GTB), a clinically approved nucleoside analogue for cancer treatment, faces therapeutic limitations due to rapid enzymatic deactivation by cytidine deaminase (CDA) in tumor microenvironments. Over 90% of systemically administered GTB undergoes catalytic conversion inactive 2'-deoxy-2',2'-difluorouracil metabolites through CDA-mediated deamination. To address this pharmacological challenge, we developed multifunctional codelivery nanosystem strategic engineering reactive oxygen...
This study focused on preparation and evaluation of a thermosensitive mucoadhesive in situ gelling ophthalmic system azithromycin (ATM). Poloxamer 407 (P407) poloxamer 188 (P188) were used as agents. Addition Carbopol 974P (CP 974P) to the systems could increase solubility ATM by salt effect enhance property systems. Gelation temperature these ranged from 31.21–36.31°C depending ratio P407 P188. Mucoadhesion force composed P407/P188/CP (21/5/0.3%, w/v) was 2.3-fold that without carbopol...
In our previous studies, ethylene glycol-linked amino acid diester prodrugs of oleanolic (OA), a Biopharmaceutics Classification System (BCS) class IV drug, designed to target peptide transporter 1 (PepT1) have been synthesized and evaluated. Unlike glycol, propylene glycol is very low toxicity in vivo. this study, was used as linker further compare the effect type on stability, permeability, affinity, bioavailability OA. Seven with acid/dipeptide promoieties containing l-Val ester (7a),...
In an effort to improve the solubility of insoluble drug scutellarin, a novel complexation scutellarin with β-cyclodextrin (β-CD) was studied. Tetracomponent freeze-dried complex prepared β-CD, Hydroxypropyl Methylcellulose (HPMC), and triethanolamine. To confirm formation, characterized by Fourier transform infrared spectroscopy (FT-IR), powder X-ray diffraction, differential scanning calorimetry (DSC). Phase-solubility analysis suggested soluble complexes having 1:1 stoichiometry. The β-CD...