A5052127094- Viral Infections and Immunology Research
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Biological Evaluation
- Pneumonia and Respiratory Infections
- Antimicrobial Resistance in Staphylococcus
- Herpesvirus Infections and Treatments
- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Antibiotic Resistance in Bacteria
- Catalytic C–H Functionalization Methods
- Viral Infectious Diseases and Gene Expression in Insects
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis of heterocyclic compounds
- Radical Photochemical Reactions
- Chemical Synthesis and Reactions
- Synthesis and biological activity
- Sulfur-Based Synthesis Techniques
- Oxidative Organic Chemistry Reactions
- RNA regulation and disease
- Cytomegalovirus and herpesvirus research
- HIV/AIDS drug development and treatment
- Animal Virus Infections Studies
Harvard University
2024
Boston VA Research Institute
2024
Bar-Ilan University
2019-2024
Kokilaben Dhirubhai Ambani Hospital
2023
National Institute of Technology Rourkela
2019-2023
Project Directorate on Foot and Mouth Disease
2011-2020
Daiichi Sankyo (India)
2013-2020
Primeasia University
2019
Indian Council of Agricultural Research
2015
Indian Veterinary Research Institute
2011-2014
Herpes simplex virus 1 (HSV-1) latent infection entails repression of viral lytic genes in neurons. By functional screening using luciferase-expressing HSV-1, we identify ten neuron-specific microRNAs potentially repressing HSV-1 neuronal replication. Transfection miR-9, the most active candidate from screen, decreases replication and gene expression Neuro-2a cells. Ectopic miR-9 lentivirus or recombinant suppresses male primary mouse neurons culture trigeminal ganglia vivo, reactivation...
Global epidemiological analysis is vital for implementing progressive regional foot-and-mouth disease control programmes. Here, we have generated VP1 region sequences 55 Indian type A outbreak strains and included complete from 46 other countries to obtain a comprehensive global phylogeographical impression. total of 26 genotypes within three continental topotypes, based on 15 % nucleotide divergence cut-off criterion, could be identified. These correlated with distinct evolutionary lineages...
Foot-and-mouth disease (FMD) is an important transboundary with substantial economic impacts. Although between-herd transmission of the has been well studied, studies focusing on within-herd using farm-level outbreak data are rare. The aim this study was to estimate parameters associated transmission, host physiological factors and FMD virus (FMDV) persistence collected from that occurred at a large, organized dairy farm in India. Of 1,836 regularly vaccinated, adult cattle, 222 had clinical...
The first of several cases meningococcal meningitis was reported in April 2005, New Delhi, India. Subsequent to this the Government declared an outbreak, which persisted for two periods, from April-July 2005 and January-March 2006. National Institute Communicable Diseases (NICD) recommended using WHO criteria diagnosis disease. During outbreak 380 clinically suspected were investigated. Of 55 diagnosed as confirmed/probable mortality rate 14.6%. Meningitis 60% meningococcaemia 40%....
The goal of this study was to characterize the properties and duration foot-and-mouth disease (FMD) carrier state associated serological responses subsequent vaccination naturally occurring infection at two farms in northern India. Despite previous cattle these herds, clinical signs FMD occurred October 2013 within a subset animals containing juvenile-yearling heifers steers (Farm A) adult dairy B). Subsequent outbreak, virus (FMDV) asymptomatic carriers were identified both herds by...
A visible light assisted dearomative selenylative carbo‐spirocyclisation of aromatic homologated‐ynones has been reported. The ynones deliver spiro‐cyclohexadienones and spiro‐diepoxides at varied temperatures. prescribed methodology is photo‐catalyst free scalable. combination light, molecular oxygen the products synthesized delivers a uniqueness to designed methodology.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and biological activities of novel 5-(2-acylethynyl)uracilsNitya G. Kundu, Biswajit Das, C. Paul Spears, Anjali Majumdar, San Ihn KangCite this: J. Med. Chem. 1990, 33, 7, 1975–1979Publication Date (Print):July 1, 1990Publication History Published online1 May 2002Published inissue 1 July 1990https://pubs.acs.org/doi/10.1021/jm00169a026https://doi.org/10.1021/jm00169a026research-articleACS PublicationsRequest reuse permissionsArticle...
RBx 11760, a novel oxazolidinone, was investigated for in vitro and vivo activity against Clostridium difficile. The of 11760 three other agents 50 diverse C. difficile clinical isolates obligate anaerobic bacteria determined. effect on sporulation toxin production determined different isolates. We used hamster infection model to investigate the efficacy vancomycin metronidazole. mechanism action ATCC 43255 by macromolecular synthesis inhibition. MICs were range 0.5–1 mg/L isolates, it...
In this study we describe the adaptive changes fixed on capsid of several foot-and-mouth disease virus serotype A strains during propagation in cell monolayers. Viruses passaged extensively three lines (BHK-21, LFBK and IB-RS-2) consistently gained positively charged amino acids putative heparin-sulfate-binding pocket (VP2 βE-βF loop, VP1 C-terminus VP3 β-B knob) surrounding fivefold symmetry axis (VP1 βF-βG loop) at other discrete sites (VP3 βG-βH C-terminus, VP2 βC strand loop). lysine...
RBx 11760, a bi-aryl oxazolidinone, was investigated for antibacterial activity against Gram-positive bacteria. The MIC90s of 11760 and linezolid Staphylococcus aureus were 2 4 mg/liter, epidermidis 0.5 Enterococcus 1 respectively. Similarly, Streptococcus pneumoniae the In time-kill studies, tedizolid, exhibited bacteriostatic effect all tested strains except S. showed 2-log10 kill at 4× MIC while tedizolid 1.4-log10 16× MIC, respectively, methicillin-resistant (MRSA) H-29. Against 5051,...
Abstract N-Iodosuccinimide in trifluoroacetic acid and anhydride was found to be an excellent reagent for the conversion of 2,4-dialkoxy pyrimidines 2,4-dialkoxy-5-iodopyrimidines. Iodination at C5-position uracil its derivatives also accomplished with above reagent.