A5079495785- Psoriasis: Treatment and Pathogenesis
- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Cytokine Signaling Pathways and Interactions
- Dermatology and Skin Diseases
- Immunodeficiency and Autoimmune Disorders
- Shoulder and Clavicle Injuries
- Orthopedic Surgery and Rehabilitation
- Cleft Lip and Palate Research
- Radiation Dose and Imaging
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Hedgehog Signaling Pathway Studies
- Autoimmune and Inflammatory Disorders Research
- Advanced X-ray and CT Imaging
- Shoulder Injury and Treatment
- Medical Imaging Techniques and Applications
- Craniofacial Disorders and Treatments
University Medical Center Utrecht
2019-2022
Center for Translational Molecular Medicine
2022
Utrecht University
2022
Maastricht University Medical Centre
2016
Maastricht University
2015
To compare immune cell phenotype and function in psoriatic arthritis (PsA) versus psoriasis order to better understand the pathogenesis of PsA.In-depth immunophenotyping different T dendritic subsets was performed patients with PsA, psoriasis, or axial spondyloarthritis healthy controls. Subsequently, we analyzed cells from peripheral blood, synovial fluid (SF), skin biopsy specimens using flow cytometry, along high-throughput transcriptome analyses functional assays on specific populations...
The incidence of positional plagiocephaly and brachycephaly in infants has increased. Treatment options include physiotherapy helmet therapy. No information exists on the prevalence, cosmetic, psychological consequences later life. This study was performed to assess prevalence cosmetic relevance brachycephaly, as well its influence quality life adolescence. authors plagiocephalomety cranial shape used a questionnaire that included question about educational level, medical history,...
Interleukin (IL)-12 and IL-23 are pro-inflammatory cytokines produced by dendritic cells (DCs) associated with Psoriasis (Pso) Psoriatic Arthritis (PsA) pathogenesis. Tofacitinib, a Janus kinase inhibitor, effectively suppresses inflammatory cascades downstream the IL-12/IL-23 axis in Pso PsA patients. Here, we investigated whether Tofacitinib directly regulates production DCs, how this regulation reflects responses to We treated monocyte-derived myeloid stimulated either lipopolysaccharide...
Background: In this study, biomechanical strength and bulkiness of the cow-hitch technique Pulvertaft weave were compared. Our goal was to investigate whether cow hitch can withstand equal in comparison with see if there is a difference bulk, which could enhance gliding function reduce friction adhesion formation. Methods: Sheep tendons used perform 10 repairs. Tensile obtained cyclic loading tensile testing machine tendon width height measurements through digital analysis by photographs...
Introduction Psoriatic arthritis (PsA) is a chronic, inflammatory, musculoskeletal disease that affects up to 30% of patients with psoriasis. Current challenges in clinical care and research include personalised treatment, understanding the divergence therapy response unravelling multifactorial pathophysiology this complex disease. Moreover, there an urgent need predict, assess understand cellular molecular pathways underlying disease-modifying antirheumatic drugs (DMARDs). The TOFA-PREDICT...
Background: Psoriatic arthritis (PsA) is a chronic inflammatory auto-immune disease characterized by an excessive production of pathogenic mediators that cause inflammation the skin, peripheral joints, entheses and spine. Among these, interleukin (IL)-23, IL-12, IL-17 family TNF constitute key players in PsA pathogenesis. 1,2 IL-23, consisting IL23A (IL-23p19) IL12B (IL-12p40) subunits, predominantly produced myeloid dendritic cells (mDCs). While p19 subunit unique to p40 shared with IL-12....
Background: Based on the unique physical properties of collagen, dualenergy computed tomography (DECT) is able to detect pathological changes in fibrous structures.This has been demonstrated for Achilles tendon (1) and traumatic disc injury elderly patients (2).Objectives: The purpose this study was assess diagnostic potential DECT collagen imaging detection intervertebral involvement with axial spondyloarthritis (axSpA) correlation osseous lesions MRI.Methods: Sixteen suspicion or known...