A5082601686- Catalytic Cross-Coupling Reactions
- Pharmacological Effects of Natural Compounds
- Mycotoxins in Agriculture and Food
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Ovarian function and disorders
- Cystic Fibrosis Research Advances
- Hepatitis C virus research
- COVID-19 Impact on Reproduction
- Bioactive Compounds in Plants
- Traditional Chinese Medicine Analysis
- Pregnancy and preeclampsia studies
- Microscopic Colitis
- Click Chemistry and Applications
- Pomegranate: compositions and health benefits
- Veterinary Practice and Education Studies
- Thallium and Germanium Studies
- Celiac Disease Research and Management
- Cardiovascular Issues in Pregnancy
- Spectroscopy and Chemometric Analyses
- COVID-19 Clinical Research Studies
- Public Health in Brazil
- Edible Oils Quality and Analysis
- Teacher Professional Development and Motivation
- HER2/EGFR in Cancer Research
- Quinazolinone synthesis and applications
Inonu University
2021-2024
Pamukkale University
2021
Istanbul Technical University
2017
A series of symmetric and unsymmetrical benzimidazolium-based N-heterocyclic carbene (NHC) precursors (1a-i) their silver complexes (2a-i) have been synthesized. The Ag(I)-NHC were characterized by 1H, 13C{1H} NMR, FTIR, LC/MS-QTOF, elemental analysis. Anticancer cytotoxic activity all tested against healthy fibroblast cell line (L929), breast cancer (MCF-7), neuroblastoma (SH-SY5Y) MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4sulfophenyl)-2H-tetrazolium] assay. 2b, 2c,...
Thioacetamide (TAA) is an organosulfur, white crystalline compound having liver injury. However, it shows toxic effects on many organs. The reverts the oxidative stress created by TAA heart and kidney, decreased lipid peroxide peroxidation back with antioxidant-properties nerolidol (NRL). This study hypothesized that NRL treatment a potential ameliorate nephrotoxicity cardiotoxicity caused TAA.Thirty-two Wistar Albino male rats (3-4 months old 280-300 g in weight) were divided into four...
Malignant pleural mesothelioma (MPM) is a malignant tumor that associated mostly with asbestos exposure. The present study was to evaluates the diagnostic value of neopterin, periostin, YKL-40, Tenascin-C (TNC), and Indolamine 2,3-dioxygenase (IDO) as noninvasive markers malign mesothelioma.Included in were 30 patients diagnosed mesothelioma, 25 people control group. Biomarker levels determined using an enzyme immunoassay . A Mann-Whitney U test Spearman correlation methods used for...
Monkeypox is a zoonotic viral infection that was first identified in humans 1970 the Democratic Republic of Congo. The cases seen again early May 2022 have reached 78.000 as today. On July 23, 2022, World Health Organization decided monkeypox outbreak represents public health emergency. For diagnosis and effective treatment monkeypox, inter-individual transmission routes, disease symptoms, factors affecting course disease, presence another infection, prognosis, pharmacological agents used...
Abstract The present study investigates the effects of resveratrol (RSV) on brain and liver tissues in rats with pembrolizumab (PEMB)‐induced toxicity. Obtained for were 28 male Sprague‐Dawley (3–4 months old) which divided into four groups: Group 1: Control. 2: Administered PEMB at 5 mg/kg/day i.p. a week. 3: RSV orally dose 20 30 days by gavage. 4: RSV, respectively, days. results this revealed that leads to significant increase thiobarbituric acid reactive substance (TBARS) levels...
Objective: To investigate the role of extracellular matrix proteins in molecular mechanism inflammatory response obese pregnant women by comparing serum levels neopterin, periostin, Tenascin-C, tissue inhibitor metalloproteinase-1, and metalloproteinase-2 between normal weight third trimester. Materials Methods:A prospective cross-sectional study was conducted April 2021 December 2021.A total 84 were included three groups formed with 28 participants each group.Results: Serum Tenascin-C...
Myocardial infarction (MI) is one of the leading causes death worldwide. In this study aimed to investigate protective effects Pistacia palaestina Boiss (PP) leaf and fruit extracts, which are thought have antioxidant anti-inflammatory properties, in isoproterenol (ISO)-induced MI. 80 Spraque-Dawley rats were divided into 10 groups. The control group was given saline. PP extracts at doses 250 mg/kg 500 applied by gavage for 21 days. ISO 100 subcutaneously administered MI MI-treatment groups...
<title>Abstract</title> A class of dietary fibers and biologically active polysaccharides from natural sources, beta-glucans (βTGs) have bioactive capabilities. The anti-tumor, anti-inflammatory, prebiotic, anti-obesity, anti-allergic, anti-microbial, antiviral, anti-osteoporotic, immunomodulating effects βTGs are well documented. Although many biological activities βTG been proven, its mechanism in DHEA-induced PCOS has not investigated. We aimed to investigate the protective treatment on...
Endometrial cancer (EC) is the fourth most common gynecologic malignancy among women. Histopathologic examination considered gold-standard for diagnosis of EC. However, these examinations sometimes not be useful in distinguishing early stage types The current study aimed to investigate clinicopathological significance Lipocalin-2 (LCN2), matrix metalloproteinase-9 (MMP9), and ferritin tumor progression. A total 98 patients (55 women newly diagnosed with early-stage endometrial [study group]...
Aim: Patulin, a mycotoxin, is an organic compound classified as polypeptide. which generally detected in moldy fruits and their derivatives, has been suggested to have anticancer activity. Some studies shown that it induces apoptosis the cell. This study aims investigate activity of patulin SH-SY5Y (human neuroblastoma cell line), HCT116 colon cancer MCF-7 breast line) lines. Materials Methods: SH-SY5Y, HCT116, MCF-7, L929 (healthy fibroblast) lines were used for cytotoxicity experiments....
Aim: Favipiravir is an effective antiviral used in the treatment of COVID-19. It metabolized by aldehyde oxidase (AO) and xanthine (XO). This study investigated drug-drug interactions between favipiravir with both AO substrate XO enzyme inhibitor, allopurinol, verapamil. 
 Material Methods: 25 Sprague-Dawley female rats, 250-300 g, were divided into five equal groups. Blood samples taken from jugular vein at end 0, 15, 30, 45 minutes, 1st, 2nd, 4th, 6th, 8th hours after drugs...
The current study's objective was to investigate the interactions of favipiravir with pioglitazone and citalopram. 25 Spraque-Dawley female rats were used in study. Rats groups 1 4 given (1 mg/kg/day) for 7 days 2 5 citalopram (1.5 days. 3, 4, a loading dose (50 mg/kg) on 6th day study maintenance (30 7th After last drug administration, blood samples taken from at 15, 30, 45 minutes, 1, 2, 6, 8 hours. Plasma concentrations drugs determined by high-performance liquid chromatography (HPLC)....
Objective: Liver transplantation using a living donor (LDLT) is currently the most popular method used in worldwide. Appropriate biomarkers that predict graft status should be to detect early post-transplant complications may lead rejection reaction. Material and Method: The study involved total of 44 liver recipients donors, from whom preoperative blood samples were taken immunoassay spectrophotometric studies carried out. levels serum neopterin, interferon-gamma (IFN- y), indoleamine-2,3...