Synthetic anion receptors are increasingly being explored for the transport of anions across lipid membranes because their potential therapeutic applications. A considerable amount research focuses on chloride, whereas transmembrane inorganic phosphate has not been reported to date, despite biological relevance this anion. Here we present a calix[4]pyrrole with bisurea strap that functions as receptor and transporter H2PO4-, relying formation eight hydrogen bonds efficient encapsulation...

This article presents the use of dynamic covalent chemistry in liposomal membranes to activate and modulate transmembrane transport chloride by addition different azine-containing compounds.

Dynamic covalent chemistry is used in many applications that require both the stability of bonds and possibility to exchange building blocks. Here we present azines as a dynamic functional group combines best characteristics imines acylhydrazones. We show are stable presence water combinatorial libraries aldehydes equilibrate less than an hour.

The effect of hydrazones and related functional groups on the anion transport activity thioureas is presented.

Macrocyclization has proven to be a useful design strategy in the development of efficient anion receptors. In addition ring size, overall preorganization by structural rigidity is key importance. To explore this context developing an pyrophosphate receptor, three macrocycles featuring 26-membered interior size and similar H-bonding motifs have been synthesized their binding ability investigated. Computational studies NMR data showed different degrees as result differences flexibility. The...

Macrocyclization has proven to be a useful design strategy in the development of efficient anion receptors. In addition ring size, overall preorganization due structural rigidity is key. To explore this context developing an pyrophosphate receptor, three macrocycles featuring 26-membered interior size and similar H-bonding motifs have been synthesized, their binding ability investigated. Computational studies nuclear magnetic resonance (NMR) data showed different degrees as result...

Macrocyclization has proven to be a useful design strategy in the development of efficient anion receptors. In addition ring size, overall preorganization by structural rigidity is key importance. To explore this context developing an pyrophosphate receptor, three macrocycles featuring 26-membered interior size and similar H-bonding motifs have been synthesized their binding ability investigated. Computational studies NMR data showed different degrees as result differences flexibility. The...

Stimuli-responsive transmembrane ion transport has become a prominent area of research due to its fundamental importance in cellular processes and potential therapeutic applications. Commonly used stimuli include pH, light, reduction or oxidation agents. This paper presents the use dynamic covalent chemistry based on azine bonds activate modulate chloride liposomes. An active transporter was obtained situ within lipid bilayer by metathesis. The activity further tuned changing structure added...

The synthesis of phosphate receptors represents an important avenue research given the ubiquity in biological and environmental systems. While many molecular scaffolds suitable for smaller anions are available either commercially or via reported synthetic routes, larger such as less common. In this work, we present a clear straightforward basic scaffold 3,6-diaminophenanthrene novel 3,6-bisureidophenanthrene anion receptor prepared from scaffold. Of seven steps using readily starting...

Synthetic anion transporters can be developed using receptors that are able to bind the and stabilize it in lipophilic interior of a bilayer membrane, they usually contain functional groups with acidic NHs, such as ureas, thioureas squaramides. To assess suitability acylhydrazones new group for preparation transporters, we have studied family functionalized these related groups. 1H NMR titrations DFT calculations indicate bearing acylhydrazone behave chloride two separate binding sites,...

Synthetic anion receptors are increasingly explored for the transport of anions across lipid membranes because their potential therapeutic applications. A considerable amount research focuses on chloride whereas transmembrane inorganic phosphate has not been reported to date, despite biological relevance this anion. Here we present a calix[4]pyrrole with bisurea strap that functions as receptor and transporter H2PO4–, relying formation 8 hydrogen bonds efficient encapsulation Using...

Synthetic anion transporters can be developed using receptors that are able to bind the and stabilize it in lipophilic interior of a bilayer membrane, they usually contain functional groups with acidic NHs, such as ureas, thioureas squaramides. To assess suitability acylhydrazones new group for preparation transporters, we have studied family functionalized these related groups. 1H NMR titrations DFT calculations indicate bearing acylhydrazone behave chloride two separate binding sites,...

Synthetic anion transporters can be developed using receptors that are able to bind the and stabilize it in lipophilic interior of a bilayer membrane, they usually contain functional groups with acidic NHs, such as ureas, thioureas squaramides. To assess suitability acylhydrazones new group for preparation transporters, we have studied family functionalized these related groups. 1H NMR titrations DFT calculations indicate bearing acylhydrazone behave chloride two separate binding sites,...

Synthetic anion transporters can be developed using receptors that are able to bind the and stabilize it in lipophilic interior of a bilayer membrane, they usually contain functional groups with acidic NHs, such as ureas, thioureas squaramides. To assess suitability acylhydrazones new group for preparation transporters, we have studied family functionalized these related groups. 1H NMR titrations DFT calculations indicate bearing acylhydrazone behave chloride two separate binding sites,...