A5038286494- Vaccine Coverage and Hesitancy
- Polyamine Metabolism and Applications
- Antibiotic Use and Resistance
- Misinformation and Its Impacts
- SARS-CoV-2 and COVID-19 Research
- Dental Erosion and Treatment
- Psychology of Moral and Emotional Judgment
- Laser Applications in Dentistry and Medicine
- COVID-19 and healthcare impacts
- Dental materials and restorations
- Reproductive System and Pregnancy
- Ferrocene Chemistry and Applications
- Synthesis and Biological Evaluation
- Health Literacy and Information Accessibility
- Pharmacovigilance and Adverse Drug Reactions
- Melanoma and MAPK Pathways
- Pneumonia and Respiratory Infections
- Epigenetics and DNA Methylation
- Electric Power System Optimization
- Toxoplasma gondii Research Studies
- Biotechnology and Related Fields
- Quinazolinone synthesis and applications
- Water Governance and Infrastructure
- Alkaline Phosphatase Research Studies
- Science and Science Education
University of Aveiro
2009-2023
Centro Universitário Cesumar
2022
Institute for Biomedicine
2022
Universidade Federal da Grande Dourados
2020
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2015-2019
Universidade do Porto
2015-2019
Universidade Estadual Paulista (Unesp)
2019
Universidade Federal do Ceará
2018
University of Coimbra
2009-2016
Lund University
2011-2015
Background The COVID-19 pandemic has had a significant impact on the population’s mental health. However, its consumption of anxiolytics, sedatives, hypnotics and antidepressants remains to be evaluated. Hence, this article aims assess prescription trends these drugs in Portugal, from January 2018 March 2021, while critically examining whether an or not. Methods A nationwide interrupted time-series analysis data outpatient setting public health sector was conducted. encompassed defined daily...
Abstract Background Coronavirus 2019 (COVID-19) has become a public-health emergency of international concern. Most efforts to contain the spread and transmission virus rely on campaigns interventions targeted reduce Vaccine Hesitancy Refusal (VHR). Objective this study aims assess major factors associated with VHR in older population Portugal. Methods nation-wide cross-sectional was conducted Portuguese (≥65 years old) through computer-assisted telephone interviewing. Logistic regression...
Background: Many clinical studies have suggested a beneficial effect of GB virus type C (GBV-C) on the course HIV-1 infection, but mechanisms involved in such amelioration are not clear. As recent evidence has implicated cellular activation pathogenesis, we investigated GBV-C viremia T-cell early infection. Methods: Forty-eight recently infected patients (23 viremic) were evaluated for counts, expanded immunophenotyping RNA detection, and viral load. Nonparametric univariate multivariate...
Coronavirus disease 2019 (COVID-19) has spread globally and is currently having a damaging impact on nearly all countries in the world. The implementation of stringent measures to stop COVID-19 dissemination had an influence healthcare services associated procedures, possibly causing antibiotic consumption fluctuations. This paper aims evaluate immediate long-term pandemic prescribing trends outpatient care Portuguese public health sector, including primary centers hospitals, as well...
The aim of this work was to investigate the effects cell handling and storage on integrity 1H high resolution magic angle spinning (HRMAS) NMR spectra. Three different types have been considered (lung tumoral, amniocytes, MG-63 osteosarcoma cells) in order for sample-dependent be identified. Cell fresh cells frozen cryopreservative solution ∼70−80%, with former showing higher membrane degradation, probably enzymatic, as indicated by increased phosphocholine (PC) and/or glycerophosphocholine...
Background New strategies are needed for breast cancer treatment and one initial step is to test new chemotherapeutic drugs in cell lines, choose candidates further studies towards clinical use. Methodology Findings The cytotoxic effects of a biogenic polyamine analogue – norspermidine its trinuclear Pd(II) Pt(II) complexes Pd3NSpd2 Pt3NSpd2, respectively were investigated immortalized normal-like three lines. MCF-10A cells least sensitive the compounds, while growth inhibition death was...
ABSTRACT The establishment of mycobacterial infection is characterized by the formation granulomas, which are well-organized aggregates immune cells, namely, infected macrophages. granuloma's main function to constrain and prevent dissemination mycobacteria while focusing response a limited area. In some cases these lesions can grow progressively into large granulomas undergo central necrosis, thereby leading their caseation. Macrophages most abundant cells present in granuloma known adapt...
Breast cancer is one of the most common malignant tumor forms among women and many succumb to their disease. Thus, new anticancer agents that can efficiently improve patient survival are utmost importance. In this study, effects polyamine analogues N (1),N (11)-bis(ethyl)norspermine (BENSpm) (1)-cyclo-propylmethyl-N (11)-ethylnorspermine (CPENSpm) synthesized dinuclear complexes Pd2BENSpm (Pd-BENSpm), Pt2CPENSpm (Pt-CPENSpm) Pd2Spm (Pd-Spm) were investigated in normal-like breast epithelial...
The polyamines are important for a variety of cellular functions, including cell growth. Their intracellular concentrations controlled by complex network regulatory mechanisms, in which antizyme (Az) has key role. Az reduces the polyamine content down-regulating both enzyme catalysing biosynthesis, ornithine decarboxylase (ODC), and uptake polyamines. activity is repressed binding protein, named inhibitor (AzI), an enzymatically inactive homologue ODC. Two forms AzI have been described:...
To contain the COVID-19 pandemic, higher vaccination rates are essential. However, as vaccine hesitancy is a reality, it important to understand what drives health professionals refuse getting vaccinated against COVID-19, who have been in frontline of this pandemic since its beginning and may be key actors improve coverage among their patients.
This paper presents a model for evaluating the optimal strategy of generation company (Genco) that trades electricity in competitive market, where two possible energy transaction markets are considered: spot market and bilateral contract market. In this context, Genco tries to maximize its profits minimize corresponding risks by selecting balance between (spot bilateral). The risk considered has different sources, named factors, which divided into categories: price volume factors. Numerical...
Abstract Aims Pregnant BALB/c mice infected with a Toxoplasma gondii type II strain were used to determine how pregnancy interferes the development of maternal immunity T and infection disrupts foetal development. Methods Maternal parasite loads assessed by amplification SAG1 using qPCR. Adverse effects evaluated on foetal‐placental quantification implantation units undergoing resorption histopathological analyses. Serum progesterone levels quantified immunoassay. The effect was determined...
The aim of the present study was to analyse content posts on Instagram about cervical cancer.It conducted a qualitative analysis using 50 most popular publicly available Portuguese-language posts, containing hashtags #cervicalcancer, #papsmear, #hpv, #papillomavirus, and #hpvvac-cine, during Brazilian national cancer prevention campaign in March 2018.Posts recruited #cervicalcancer provided 60% with contents related secondary prevention; #papsmear 46% irrelevant contents; #hpv...
In the last years, electricity markets have been changing from monopolies to liberalized markets, and consequently, with entrance of new providers, there has an increase competitiveness. With creation open utilities faced need understand way prices change, in order better develop bidding hedging strategies. This paper focuses on Spanish market. a model capable evaluating predicting prices, we use data January 1998 until August 2005. addition, as one aims is get short medium term forecasts,...
The inappropriate use of antibiotics for respiratory tract infections is dispersed worldwide, thus being a strong contributor to antibiotic resistances. As the educational interventions among health practitioners shown have an impact on judicious use, online course (eHealthResp) has been developed, especially targeted pharmacists and physicians. Thus, main goal this study validate contents eHealthResp. This two-round Delphi involved recruitment multidisciplinary panel (n = 19), which...