Vitamin D deficiency increases the risk of developing diabetes, dyslipidemia, and other chronic diseases. We aimed to investigate relationship between vitamin deficiency, glycemic levels, lipid profiles in individuals with prediabetes nondiabetes. This observational cross-sectional study was conducted on 249 adults who were divided into 2 groups based American Diabetes Association classification: nondiabetics prediabetics. The serum profiles, fasting blood glucose hemoglobin A1c insulin...

This study explores the possible therapeutic role of rats and mice bone marrow-derived mesenchymal stem cells (BM-MSCs) on renal damage toxicity brought by carbon tetrachloride (CCl

Background Aflatoxins are highly potent mycotoxins that can seriously harm the health of humans and a variety animal species. On other hand, camel milk silymarin offer positive effects for many In addition, reduce impact AFB1 on hematology, serum biochemical markers, histopathology liver testes, expression inflammatory, antioxidant, male reproductive genes. Methods 40 rats were used to evaluate beneficial effect against aflatoxin B1 (AFB1) toxicity in rats. The classified treatments control...

Purpose The present study investigated the nephron-testicular protective effects of sesamin against cisplatin (CP)-induced acute renal and testicular injuries.

This study aims to investigate the effect of hydroethanolic extracts Cynara scolymus (C. scolymus) leaf (CLHE) and C. flower (CFHE) on hepatic histopathological lesions functional biochemical changes induced by type 2 diabetes mellitus (T2DM). The rat model T2DM was intraperitoneal injection streptozotocin (STZ) in a dose 60 mg/kg for 15 minutes following nicotinamide (NA) (60 mg/kg). rats were allocated into four groups: group 1 (negative control), (diabetic 3 supplemented with 100...

Peptic ulcer is a widespread disease, with lifetime frequency of 5–10% among the general population and an annual incidence 0.1–0.3%. Ovothiol A naturally produced from sea urchin eggs special antioxidant activity. Gastric ulcers were induced in rats by single ethanol dose (5 mL/kg). The divided into control, ulcer, 250 500 mg/kg ovothiol doses. Molecular docking studies used to examine interactions between H+/K+ ATPase active site residues. led significant decline (p < 0.05) gastric...

recent studies show a good relationship between breast cancer (BC) and human papillomaviruses (HPV) wich is responsible for about 18% of BC cases. This study aimed to assess the different genotypes HPV expression P53 retinoblastoma (RB) genes estrogen progesterone receptors in among Sudanese women.one hundred fifty tissue blocks were obtained from females diagnosed with BC. Positive samples used determine an applied biosystem (ABI 3730XL) genetic analyzer sequencing...

Acute kidney injury (AKI) is a prevalent medical condition accompanied by mutual affection of other organs, including the liver resulting in complicated multiorgan malfunction. Macrophages play vital role during tissue and healing; they are categorized into "classically activated macrophages" (M1) "alternatively (M2). The present study investigated compared conventional fluid therapy vs Dipeptidyl peptidase 4 inhibitor (DPP-4i) vildagliptin on induced AKI evaluated possible molecular...

Asthma is a persistent inflammatory disease of the bronchi characterized by oxidative stress, airway remodeling, and inflammation. Echinochrome (Ech) dark-red pigment with antioxidant anti-inflammatory activities. In this research, we aimed to investigate effects Ech against asthma-induced inflammation, histopathological alterations in spleen, liver, kidney mice. Mice were divided into four groups (n = 8 for each): control, asthmatic, asthmatic mice treated intraperitoneally 0.1 1 mg/kg Ech....

The occurrence of worsening pulmonary function has been connected to hypothyroidism (HPO). Hesperidin (HES) was suggested have antioxidant, anti-proliferative, and anti-inflammatory potential. Our study's objective determine whether HES could reduce carbimazole (CBZ)-induced lung injury more effectively than Eltroxin (ELT) in adult male albino rats or not. At random, 32 were distributed into four groups: Group I: normal control, induce HPO, the remaining three groups given CBZ (20 mg/kg/day)...

Background Fibromyalgia (FM) is characterized by musculoskeletal pain, fatigue, sleep and memory disturbance. There no definitive cure yet for FM-related health problems. Peroxisome proliferator-activated receptor's (PPAR's) activation associated with insulin sensitisation improved glucose metabolism. PPAR-γ was reported to alleviate FM allodynia. Limited data are discussing its effect on motor disorders.Objective To investigate the potential of agonists (pioglitazone, as one member...

Diabetes mellitus is an oxidative stress-related disease characterized by hyperglycemia and a variety of complications, including nephropathy. Vitamin D has variable functions extending beyond the calcium metabolism to prevent tissue damage. We aimed investigate whether vitamin supplements could enhance Glibenclamide's effectiveness in treating diabetes minimize risk associated pathology. Wistar rats were divided into normal control (n = 10) diabetic 30), where animals received two low doses...

Background Hemolytic anemia (HA) is a serious health condition resulting from reduced erythrocytes’ average life span. Echinochrome (Ech) dark-red pigment found in shells and spines of sea urchins. Aim Studying the potential therapeutic effect Ech on phenylhydrazine (PHZ)-induced HA rats. Methods Eighteen rats were divided into three groups ( n = 6): control group, phenylhydrazine-induced group injected intraperitoneally with PHZ supplemented oral daily for 6 days. Results resulted...

Colorectal cancer, one of the most frequently diagnosed cancers worldwide, has a high mortality rate. Thus, our research aims to examine preventive effects diosmin (DIO) alone and in conjunction with anti-cancer drug irinotecan (camptothecin-11, CPT-11), on 1,2-dimethylhydrazine (DMH)-induced colon cancer (CC) male Wistar rats.

We investigated the protective effect of green tea on diabetic hepato-renal complications. Thirty male Wistar rats were randomly divided into five equal groups: normal control, glibenclamide-treated, tea-treated, and combined therapy-treated groups; ethical approval number "BERC-014-01-20." After eight weeks, animals sacrificed by CO2 euthanasia method, liver kidney tissues processed stained for pathological changes, blood samples collected biochemical analysis. Diabetic showed multiple...

Rheumatoid arthritis (RA) is associated with joint damage. For treatment, non-steroidal anti-inflammatory drugs (NSAIDs), steroidal agents, and immune-suppressants are used. Their side-effects require a safe effective natural alternative.Thirty-six male albino rats, half kept under observation for 1 week (group I) others 2 weeks II) were Each group was subdivided into: normal (A), RA (B), oral mandarin-peel extract (MPE) treated (C). Ankle diameter, serum levels of RF, interleukin (IL)-1β,...

Pre-eclampsia poses a significant potential risk of hypertensive disorders during pregnancy, leading cause maternal deaths. Hyperuricemia is associated with adverse effects on endothelial function, normal cellular metabolism, and platelet aggregation adhesion. This study was designed to compare serum urate levels in normotensive pregnant women those pregnancy-induced hypertension, evaluate its value as predictive marker hypertension severity pregnancy.A prospective, observational,...

A gastric ulcer is a break in the normal mucosa integrity that extends through muscularis into sub-mucosa or deeper.This work aimed to study effect of chronic administration vinegar on acid secretion, and if this action has any stress-induced male albino rats.Study groups included 24 rats divided 2 main (12 rats/group): pyloric ligation group (A) water immersion-induced ulceration (as form stress) (B).We evaluated; free total HCL secretion A, score, index, percentage protection, , eNOS...

Background: Rheumatoid arthritis (RA), the most common cause of arthritis, is a chronic autoimmune disease multifactorial etiology characterized by synovial hyperplasia, autoantibody production, cartilage and bone destruction, joint malformation systemic features in form cardiovascular, pulmonary, psychological, skeletal disorders.Its prevalence 1% population.The pathogenesis RA still not fully understood.RA starts cascade inflammatory events lead to degradation tissues.It low interferon γ...

Gastric hyperacidity is a serious health problem of global concern.This work was conducted to study the effect chronic administration omega-3 polyunsaturated fatty acids (PUFA) on HCl secretion and stress-induced ulcer in male albino rats.Study groups included 24 rats divided into 2 main with 12 each as follows: pyloric ligation group (A) water immersion-induced gastric ulceration (B).Each subgroup contained 6 rats.Among parameters estimated studied were: free total HCL A, score, index,...

Introduction Type 2 diabetes mellitus (DM) and Alzheimer’s disease (AD) are two major medical conditions that constitute a significant financial burden on most healthcare systems. Due to AD sharing “insulin resistance” mechanistic features with DM, some scientists have proposed “type 3 DM” terminology for it. This study aims compare the prophylactic effect of exercise metformin cognitive brain functions in rats type DM. Material methods Two groups were included study: control group (n = 15)...