A5021177445- Chemical Synthesis and Analysis
- Antimicrobial Peptides and Activities
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Advanced Biosensing Techniques and Applications
- bioluminescence and chemiluminescence research
- Enzyme Structure and Function
- Genetics, Aging, and Longevity in Model Organisms
- Analytical Chemistry and Chromatography
- Protein Structure and Dynamics
- Carbohydrate Chemistry and Synthesis
- Telomeres, Telomerase, and Senescence
- Receptor Mechanisms and Signaling
- Molecular spectroscopy and chirality
- Spectroscopy and Quantum Chemical Studies
ETH Zurich
2017-2022
Incorporating small modifications to peptidic macrocycles can have a major influence on their properties. For instance, N-methylation has been shown impact permeability. A better understanding of the relationship between permeability and structure is key importance as drugs are often associated with unfavorable pharmacokinetic profiles. Starting from semipeptidic macrocycle backbone composed tripeptide tethered head-to-tail an alkyl linker, we investigated two changes: peptide-to-peptoid...
Binding of cations leads to inversion conformational preference cyclic octadepsipeptides and may be connected incorporation in membranes.
1 H and 13 C chemical shifts of 35 small, rigid molecules were measured under standardized conditions in CDCl 3 CCl 4 . Specific solvent interactions lead to shift differences that cannot be reproduced by DFT implicit solvent.
Proteins with large and flat binding sites as well protein–protein interactions are considered ' undruggable conventional small-molecule drugs. Cyclic peptides have been found to be capable of such targets high affinity, making this class compounds an interesting source for possible therapeutics. However, the oftentimes poor passive membrane permeability cyclic still imposes restrictions on applicability peptide Here, we describe how computational methods in combination experimental data can...