A5067172527- Animal Disease Management and Epidemiology
- Animal Virus Infections Studies
- Virology and Viral Diseases
- Monoclonal and Polyclonal Antibodies Research
- Viral Infections and Vectors
- Virus-based gene therapy research
- Bacteriophages and microbial interactions
- Vector-Borne Animal Diseases
- Viral gastroenteritis research and epidemiology
- Herpesvirus Infections and Treatments
- Livestock and Poultry Management
- Parvovirus B19 Infection Studies
- vaccines and immunoinformatics approaches
- Influenza Virus Research Studies
- Veterinary medicine and infectious diseases
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Helicobacter pylori-related gastroenterology studies
- Advanced Biosensing Techniques and Applications
- Helminth infection and control
- Plant Virus Research Studies
- Genetic and phenotypic traits in livestock
- Fungal Infections and Studies
- Toxin Mechanisms and Immunotoxins
- Poxvirus research and outbreaks
University of Ibadan
2015-2024
Pan-Atlantic University
2022-2023
Cancer Research Center
2013
Auburn University
2008-2012
Rapid mutation rates and correspondingly high levels of intra- interhost diversity are often cited as key features viruses with the capacity for emergence sustained transmission in a new host species. However, most this information comes from studies RNA viruses, relatively little known about evolutionary processes single-stranded DNA (ssDNA) genomes. Here, we provide unique model virus evolution, integrating both long-term global-scale short-term intrahost an ssDNA that emerged to cause...
To explore cancer cell-specific phage fusion pVIII coat protein, identified using display, for targeted delivery of drug-loaded liposomes to MCF-7 breast cells.An 8-mer landscape library f8/8 and a biopanning protocol against cells were used select protein bearing MCF-7-specific peptide. Size morphology doxorubicin-loaded modified with the tumor-specific (phage-Doxil) determined by dynamic light scattering freeze-fraction electron microscopy. Topology in was examined western blot....
Breast cancer is a leading cause of death among women in the USA. The efficacy existing anticancer therapeutics can be improved by targeting them through conjugation with ligands binding to cellular receptors. Recently, we developed novel drug strategy based on use pre-selected cancer-specific 'fusion pVIII proteins' (fpVIII), as ligands. To study efficiency this approach animal models, panel breast cell-binding phages source targeted fpVIIIs. Two landscape phage peptide libraries (8-mer...
Sera samples from seven poultry farms in southwest Nigeria consisting of 7 broiler, 10 pullet, 1 layer, cockerel, and broiler breeder flocks were tested for the presence chicken infectious anemia virus (CIAV) antibodies using a commercial enzyme-linked immunosorbent assay kit. Eleven 20 (55%) six out (86%) positive CIAV antibodies. The seroprevalence largely depended on age flocks. Seroprevalence was higher within older pullet layer (83%–100%) than younger (0%–83%). In essence, all 6 to 8 wk...
Chicken anemia virus (CAV) was isolated for the first time from Nigerian chicken population. The recovered necropsied birds broiler and pullet flocks that suffered disease outbreaks tentatively diagnosed as infectious bursal disease. A sensitive polymerase chain reaction (PCR) assay detected CAV DNA in tissues of birds. Restriction endonuclease analysis performed with 733-bp PCR product Cfo I enzyme indicated at least two different CAVs were circulating among Four isolates obtained pooled...
We developed a natural challenge method using sentinel chickens reared on litter contaminated with infectious laryngotracheitis (ILT) vaccine virus (V) and nested polymerase chain reaction (PCR) to determine the presence of ILTV in feces tracheas chickens. In 3 separate experiments, we determined that several commercially available poultry treatments (Poultry Guard, Al+Clear, PLT), heating 38°C (100°F) for 24 h, in-house composting 5 d reduced below our detection level. This information is...
Abstract Background One of the cardinal requirements for effective therapeutic management tumors is selective delivery cancer drugs to right site by ligand-decorated nanomedicines. Screening 2 × 10 9 clone landscape phage library provides a reliable avenue generating protein ligands specific tumor cells. It was shown that proteins derived from libraries against breast and prostate cells are able navigate drug or siRNA loaded liposomes corresponding with minimal toxicity non-neoplastic In an...
To conduct sero-epidemiological and virological surveillance for lowly pathogenic avian influenza virus (LPAIV) in apparently healthy birds slaughtered at live-bird markets (LBMs) Southwestern Nigeria. A competitive ELISA was used detecting virus-specific antibodies 491 chicken sera obtained from five LBMs Oyo Ogun States, Nigeria while haemagglutination inhibiting against LPAIVs were detected using H5N2, H7N1 H9N2 subtype-specific antigens. Suspensions prepared 400 cloacal swabs inoculated...
Avian Influenza Virus (AIV) especially the highly pathogenic subtype H5Nx causes (AI) disease and it is a major threat to poultry industry public health worldwide. Vaccination one of control measures in many countries, though restricted Nigeria. As such, some farmers secretly employ imported H5 H9 AI vaccines vaccinate their chickens. This study investigated antigenic quality these vaccines. Four vaccine brands were tested using Hemagglutination (HA) test Reverse Transcriptase Polymerase...
Newcastle disease represents an enormous problem for African breeders, and country-specific fears economic exchanges complicate its elimination control. Slow laboratory diagnosis creates additional delays during initial epidemic discovery. To address these concerns, researchers undertook a study in Ethiopia to examine the impact of circulating virus on chicken farms. The aim is identify from likely outbreak cases, confirm pathogenicity, evaluate effects vaccinated uninfected chicks Forty...
ABSTRACT Canine parvovirus (CPV) is a highly successful pathogen that has sustained pandemic circulation in dogs for more than 40 years. Here, integrating full-genome and deep sequencing analyses, structural information, vitro experimentation, we describe the macro- micro-scale features have accompanied CPV’s evolutionary success. Despite years of viral evolution, all CPV variants are >∼99% identical nucleotide sequence, with only limited number (<40) mutations becoming fixed or...
An outbreak of infectious bursal disease (IBD) occurred in a flock 11-week old crossbreeds Harco cocks and indigenous Nigerian hens (referred to as exotic locals respectively the text). Clinical signs observed include depression, anorexia, ruffled feathers diarrhoea. Haemorrhages were present bursa Fabricius, muscles proventriculus-gizzard junction, while bursae kidneys enlarged. Oedema, lymphocytic depletion presence remnants dead lymphocytes histopathological sections spleen. IBD viral...
Abstract Background Pueraria tuberosa (Willd) D.C. (Fabaceae) tubers are already used in traditional medicine by Ayurvedic physicians for the management of fertility disorders, general weakness, and also as anti-ageing therapies. Other known pharmacological properties include: anti-hyperglycemics, hepatoprotective, anti-hyperlipidemic, diuretic, nutritive, anti-fertility agents male rats. Methods The anti-proliferative effect aqueous tuberous root extract on vascular smooth muscle cells...
Newcastle disease (ND) caused by ND virus (NDV) is a serious impediment to effective poultry production in developing countries such as Nigeria. Despite employing vaccination and other control measures curtail this disease, its severe forms still persist. This study aimed confirm the strains NDV vaccine brands commonly used We employed reverse-transcription polymerase chain reaction (RT-PCR), sequencing, sequence analysis characterize four vaccines Fragments of 300 bp from fusion genes were...
Grasscutter (Thryonomys swinderianus) is a large rodent distributed across sub-Saharan Africa that highly valued as source of protein. There has been little effort to evaluate the genetic structure grasscutters despite long-term harvesting pressure and over 40 years grasscutter domestication in West Africa. Our objectives were quantify wild grasscutters, compare variation from samples those various farmed within south-western Nigeria. We genotyped 145 88 domesticated individuals at 11...