A5025301610- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- vaccines and immunoinformatics approaches
- Hepatitis B Virus Studies
- Immunotherapy and Immune Responses
Universität Hamburg
2024
University Medical Center Hamburg-Eppendorf
2024
German Center for Infection Research
2024
Bernhard Nocht Institute for Tropical Medicine
2024
University of Oxford
2022
Objective The transcriptional response in the liver during HCV infection is critical for determining clinical outcomes. This issue remains relatively unexplored as tissue access to address this at scale usually limited. We aimed profile transcriptomics of HCV-infected livers describe expression networks involved and assess effect on them major predictors outcome such IFNL4 (interferon lambda 4) host genotype sex. Design took advantage a large study therapy accompanied by baseline biopsy...
Licensed vaccines against the Middle East respiratory syndrome coronavirus (MERS-CoV), an emerging pathogen of concern, are lacking. The modified vaccinia virus Ankara vector-based vaccine MVA-MERS-S, expressing MERS-CoV-spike glycoprotein (MERS-S), is one 3 candidate in clinical development and elicits robust humoral cellular immunity. Here, we identified for first time a MERS-S-specific CD8+ T-cell epitope HLA-A*03:01/HLA-B*35:01-positive vaccinee using screening assay, intracellular...