A5066416832- Cutaneous Melanoma Detection and Management
- Melanoma and MAPK Pathways
- DNA and Nucleic Acid Chemistry
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Congenital limb and hand anomalies
- Estrogen and related hormone effects
- Prenatal Screening and Diagnostics
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Dermatoglyphics and Human Traits
- Natural Language Processing Techniques
- Nonmelanoma Skin Cancer Studies
- Sexual Differentiation and Disorders
- Muscle Physiology and Disorders
- Muscle metabolism and nutrition
- dental development and anomalies
- Temporomandibular Joint Disorders
- Insect Utilization and Effects
- Virus-based gene therapy research
- bioluminescence and chemiluminescence research
- Genomic variations and chromosomal abnormalities
- Cleft Lip and Palate Research
- Metal complexes synthesis and properties
- Insect Pest Control Strategies
- Orthodontics and Dentofacial Orthopedics
California Pacific Medical Center
2013-2024
Michigan State University
2002-2018
University of California, San Francisco
2004-2015
San Francisco VA Medical Center
2013-2015
Northern California Melanoma Center
2002-2012
Melanoma Institute Australia
2004-2012
Pennsylvania State University
1973-2012
UCSF Helen Diller Family Comprehensive Cancer Center
2012
Kiel University
2009
University of Duisburg-Essen
2009
Because of the paucity available tissue, little information has previously been regarding gene expression profiles primary melanomas. To understand molecular basis melanoma progression, we compared a series nevi, melanomas, and metastases. We found that metastatic melanomas exhibit two dichotomous patterns expression, which unexpectedly reflect differences already apparent in comparing laser-capture microdissected radial vertical phases large melanoma. Unsupervised hierarchical clustering...
Data on nonspecific mental retardation in two or more sibs ascertained from the British Columbia Health Surveillance Registry are utilized to calculate frequency of X-linked population (B.C.). In 1950-1969 birth cohort there 107 sibships with only males affected and 35 females giving an excess 72 male-affected sibships. Family histories mentally retarded provide evidence that mothers carriers retardation. Thus, a 1.83 per 1,000 for carrier 2.44 calculated. This can account all who We...
AN acquired immune deficiency in male homosexuals that is manifested by infection with one or more opportunistic microorganisms has recently been recognized. These agents have included cytomegalovirus, Toxoplasma gondii, Pneumocystis carinii, Candida albicans, Mycobacterium avium–intracellulare, and Cryptococcus neoformans.1 2 3 4 A prolonged clinical course an otherwise self-limited infection, such as herpes simplex also described,3 a remarkable incidence of Kaposi's sarcoma reported.1 5 In...
Monozygotic twins discordant for a congenital cranial dysinnervation disorder with features of Moebius syndrome,
Although p53 is inactivated by point mutations in many tumors, melanomas infrequently harbor the gene. Here we investigate biological role of microRNA-18b (miR-18b) melanoma targeting MDM2-p53 pathway.Expression miR-18b was examined nevi (n = 48) and 92) samples cell lines normal melanocytes. Immunoblotting performed to determine expression various proteins regulated miR-18b. The effects overexpression were investigated using assays colony formation, viability, migration, invasion, cycle a...
Melanoma brain metastasis is associated with an extremely poor prognosis, a median overall survival of 4-5 months. Since 2011, the patients stage IV melanoma has been significantly improved advent new targeted therapies and checkpoint inhibitors. We analyze outcomes diagnosed after introduction these novel drugs.We performed retrospective analysis our center database identified 79 between 2011 2015.The time from primary diagnosis to was 3.2 years. The duration initial 12.8 Following...
PURPOSE: The vascular supply of the primary tumor is recognized to play an important role in progression a number solid tumors. However, vascularity prognostic assessment melanoma remains unclear. purpose this study was determine impact patterns on outcome associated with cutaneous melanoma. PATIENTS AND METHODS: Tumor documented prospectively using routine histopathologic analysis 417 melanomas from University California at San Francisco Melanoma Center database. Four were recorded: absent,...
<h3>Objective</h3> To examine the role of vascular invasion as a prognostic factor in melanoma. <h3>Design</h3> Retrospective survival analysis. <h3>Setting</h3> Academic medical center. <h3>Patients</h3> A total 526 patients with primary cutaneous melanoma from University California, San Francisco, Melanoma Center database 2 years follow-up or documented relapse. <h3>Main Outcome Measures</h3> (1) Presence involvement defined tumor cells within blood lymphatic vessels; uncertain invasion,...
Abstract We studied 9 patients with motor neuron disease and lymphoma. The following several observations have not been recognized in the past: (1) Motor syndromes are associated either Hodgkin's or non‐Hodgkin's (2) restricted to lower disorders; 8 of had definite probable upper signs as well, qualifying for diagnosis amyotrophic lateral sclerosis. Corticospinal tracts were affected both postmortem examinations. (3) combination lymphoma is often accompanied by paraproteinemia (3 7 studied),...
From 1984 to 1988, 11 of 120 patients (9%) with motor neuron disease (MND) had paraproteins detected by serum immunofixation electrophoresis (IFE), compared 4 (3%) cellulose acetate gels: 1 patient progressive spinal muscular atrophy, 5 amyotrophic lateral sclerosis (ALS), and ALS probable upper signs. Four (80%) cerebrospinal fluid (CSF) protein content above 75 mg/dl paraproteins, as did 6 30 values 50 mg/dl. 14 oligoclonal bands (OCB) also paraproteins. Two ALS, CSF mg/dl, paraproteinemia...
The histopathological diagnosis of melanoma can be challenging. No currently used molecular markers accurately distinguish between nevus and melanoma. Recent transcriptome analyses have shown the differential expression several genes in progression. Here, we describe a multi-marker diagnostic assay using 5 (ARPC2, FN1, RGS1, SPP1, WNT2) overexpressed melanomas. Immunohistochemical marker was analyzed 693 melanocytic neoplasms comprising training set (tissue microarray 534 melanomas nevi), 4...
An experiment was performed to determine the bias-reducing effect of administering a social science questionnaire by computer. It assumed-that subjects would regard typing answers directly into computer as situation which guaranteed them greater sense privacy and anonymity than conventional wherein questionnaires or psychological tests are filled out hand then scrutinized, scored, interpreted other human beings. Based upon this assumption, two specific hypotheses were formulated: first,...
Bromodomain PHD finger transcription factor (BPTF) plays an important role in chromatin remodeling, but its functional tumor progression is incompletely understood. Here we explore the oncogenic effects of BPTF melanoma. The consequences differential expression were explored using shRNA-mediated knockdown several melanoma cell lines. Immunoblotting was used to assess various proteins regulated by BPTF. investigated assays colony formation, invasion, cycle, sensitivity selective BRAF...
The present concepts of amyotonia congenita are briefly outlined. Particular reference is made to the clinical syndrome benign congenital hypotonia, which corresponds Oppenheim's original concept a sporadic condition and represents cases not due infantile progressive muscular atrophy on symptomatic any other disease entity. case boy reported who has such form as well undescended testes, delayed osseous development few stigmata. He been studied from birth age nearly 3 years found have an...
This case report presents the pedigree of a family with hereditary ectodermal dysplasia hidrotic type in which various members showed sensori-neural hearing loss, polydactylism, and syndactylism. In addition affected an elevation electrolyte concentrations sweat. appears to be new syndrome.
A pedigree of a family with hereditary hypoplasia the enamel has been described, in which all affected members show characteristic curly hair. This combination not previously reported.