A5091550420- Aldose Reductase and Taurine
- Diabetes Treatment and Management
- Eicosanoids and Hypertension Pharmacology
- Peptidase Inhibition and Analysis
- Synthesis and biological activity
- Adenosine and Purinergic Signaling
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and properties of polymers
- Photopolymerization techniques and applications
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Computational Drug Discovery Methods
- Silicone and Siloxane Chemistry
- Polyamine Metabolism and Applications
- Neuropeptides and Animal Physiology
- Click Chemistry and Applications
Universidade Federal de Pernambuco
2024-2025
Abstract This investigation into the potential of 2‐thiopyrimidinones derivatives as inhibitors α‐adrenergic receptors demonstrated promising results for their use in antihypertensive therapy. The proposed compounds, derivatives, were evaluated through ex vivo vascular reactivity assays Wistar rat arteries, and interaction modes these compounds with α 1A ‐adrenergic analyzed molecular docking simulations. Six 22 drug candidates inhibited phenylephrine‐induced contraction isolated aorta,...
Abstract Type 2 diabetes is a chronic disease characterized by insulin resistance and alterations in incretin secretion, such as the glucagon‐like peptide‐1 (GLP‐1) hormone. GLP‐1 plays crucial role signaling production pancreas, with its activity regulated dipeptidyl peptidase 4 (DPP‐4) enzyme. DPP‐4 presents an intriguing strategy for controlling type diabetes. This study focuses on synthesizing 22 novel oxadiazolone pyrimidinone derivatives, vitro inhibition, elucidating binding modes...
Abstract Angiotensin‐converting enzyme inhibitors are widely used in treating arterial hypertension, acting on the renin‐angiotensin‐aldosterone system and controlling blood pressure. We present a novel, greener, faster methodology to assess 1,2,4‐oxadiazol‐5‐one ring perform molecular modifications obtain angiotensin‐converting (ACE) using this heterocyclic core. Molecular docking simulations indicate that tested compounds exhibited an affinity for ACE binding site, with scores comparable...
This research aims to develop new 3D (three-dimensional) printable resins made from methacrylate salts of imidazole, 2-methyl-imidazole, and 1-methyl-imidazole, with glycerol trimethacrylate serving as a crosslinking agent. With their backbone structure, these are easy rapid prepare, offering an alternative conventional ones. Reinforced terpene-based additives such α-pinene, (R)-limonene, trans-ethyl cinnamate, safrole, they present diverse range fifteen resin formulations. Each underwent...
Diabetes is a chronic metabolic disorder characterized by insufficient insulin production, the cells’ inability to use this insulin, or combination of both, leading secondary complications such as diabetic neuropathy and retinopathy. One way prevent control aldose reductase (AR) inhibitors. In work, we synthesized tested new candidates for human AR inhibition containing 2-thiopyrimidin-4-one heterocycle central ring. The fifteen derivatives were in vitro their binding modes evaluated via...