A5041637387- Molecular spectroscopy and chirality
- Cancer therapeutics and mechanisms
- Axial and Atropisomeric Chirality Synthesis
- Spectroscopy and Quantum Chemical Studies
- Mycobacterium research and diagnosis
- Sulfur Compounds in Biology
- Tuberculosis Research and Epidemiology
- Lanthanide and Transition Metal Complexes
- Molecular Sensors and Ion Detection
- Antibiotic Resistance in Bacteria
- Neutropenia and Cancer Infections
- Biochemical Analysis and Sensing Techniques
- Antioxidant Activity and Oxidative Stress
Jagiellonian University
2023-2024
Wrocław University of Science and Technology
2018
University of Wrocław
2017
In living organisms, carotenoids are incorporated in biomembranes, remarkably modulating their mechanical characteristics, fluidity, and permeability. Significant resonance enhancement of Raman optical activity (ROA) signals carotenoid chiral aggregates makes ROA (RROA), a highly selective tool to study exclusively assemblies model membranes. Hence, RROA is combined with electronic circular dichroism (ECD), dynamic light scattering (DLS), molecular dynamics, quantum-chemical calculations...
Amsacrine, which inhibits eukaryotic type II topoisomerase via DNA intercalation and stabilization of the cleavable topoisomerase-DNA complex, promotes damage eventually cell death. Amsacrine has also been shown to inhibit structurally distinct bacterial I topoisomerases (TopAs), including mycobacterial TopA, only essential in Mycobacterium tuberculosis. Here, we describe modifications an amsacrine sulfonamide moiety that presumably interacts with notably increased enzyme inhibition drug...
Abstract Coherent anti‐Stokes Raman scattering‐Raman optical activity (CARS‐ROA) is a coherent version of spontaneous ROA spectroscopy, the latter being well‐established chirally sensitive vibrational spectroscopic technique. A central major advantage heterodyne‐detected CARS‐ROA over drastic reduction acquisition times from several hours to approximately 1 min due high ratio chiral signal relative achiral CARS background. Here, we present first demonstration molecules dissolved in an...