A5052244609- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Gallbladder and Bile Duct Disorders
- Cholesterol and Lipid Metabolism
- Estrogen and related hormone effects
- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Pancreatitis Pathology and Treatment
- Congenital gastrointestinal and neural anomalies
- Alcohol Consumption and Health Effects
- Pediatric Hepatobiliary Diseases and Treatments
- Silymarin and Mushroom Poisoning
- Helicobacter pylori-related gastroenterology studies
- Drug-Induced Hepatotoxicity and Protection
- Diverticular Disease and Complications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Screening and Detection
- Pancreatic and Hepatic Oncology Research
- Biomedical Research and Pathophysiology
- Eicosanoids and Hypertension Pharmacology
- Anorectal Disease Treatments and Outcomes
- Ion Transport and Channel Regulation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Glycogen Storage Diseases and Myoclonus
Saint Louis University
2011-2020
University of Bari Aldo Moro
2012-2018
UCLouvain Saint-Louis Brussels
2013-2014
Epidemiological and clinical studies have found that gallstone prevalence is twice as high in women men at all ages every population studied. Hormonal changes occurring during pregnancy put higher risk. The incidence rates of biliary sludge (a precursor to gallstones) gallstones are up 30 12%, respectively, postpartum, 1-3% pregnant undergo cholecystectomy due symptoms or complications within the first year postpartum. Increased estrogen levels induce significant metabolic hepatobiliary...
To distinguish the lithogenic effect of classical estrogen receptor α (ERα) from that G protein-coupled 30 (GPR30), a new receptor, on estrogen-induced gallstones, we investigated entire spectrum cholesterol crystallization pathways and sequences during early stage gallstone formation in gallbladder bile ovariectomized female wild-type, GPR30((-/-)), ERα((-/-)), GPR30((-/-))/ERα((-/-)) mice treated with 17β-estradiol (E2) at 6 µg/day fed diet for 12 days. E2 disrupted biliary salt metabolism...
To investigate the effectiveness of antioxidant compounds in modulating mitochondrial oxidative alterations and lipids accumulation fatty hepatocytes.Silybin-phospholipid complex containing vitamin E (Realsil(®)) was daily administered by gavage (one pouch diluted 3 mL water 15 mg 47 silybin complexed with phospholipids) to rats fed a choline-deprived (CD) or high fat diet [20% fat, 71% total calories as 11% carbohydrate, 18% protein, (HFD)] for 30 d 60 d, respectively. The control group...
The cholesterol absorption inhibitor ezetimibe can significantly reduce plasma concentrations by inhibiting the Niemann-Pick C1-like 1 protein (NPC1L1), an intestinal sterol influx transporter that actively facilitate uptake of for absorption. Unexpectedly, treatment also induces a complete resistance to gallstone formation and nonalcoholic fatty liver disease (NAFLD) in addition preventing hypercholesterolemia mice on Western diet. Because chylomicrons are vehicles with which enterocytes...
Nuclear receptors (NRs) comprise one of the most abundant classes transcriptional regulators metabolic diseases and have emerged as promising pharmaceutical targets. Small heterodimer partner (SHP; NR0B2) is a unique orphan NR lacking DNA-binding domain but contains putative ligand-binding domain. SHP regulator affecting multiple key biological functions processes including cholesterol, bile acid, fatty acid metabolism, well reproductive biology glucose-energy homeostasis. About half all...
Background and Aims Estrogen is an important risk factor for cholesterol gallstone disease because women are twice as likely men to form gallstones. The classical estrogen receptor α (ERα), but not ERβ, in the liver plays a critical role formation of estrogen‐induced gallstones female mice. molecular mechanisms underlying lithogenic effect on have become more complicated with identification G protein–coupled 30 (GPR30), receptor. Approach Results We investigated biliary phenotypes...
Abstract Background Oestrogen is an important risk factor for cholesterol cholelithiasis not only in women of childbearing age taking oral contraceptives and postmenopausal undergoing hormone replacement therapy, but also male patients receiving oestrogen therapy prostatic cancer. In women, hormonal changes occurring during pregnancy markedly increase the developing gallstones. We investigated whether potent absorption inhibitor ezetimibe could prevent formation oestrogen‐induced gallstones...
Background A failure of hepatic cholesterol (Ch) homoeostasis, in which the physical‐chemical balance Ch solubility bile is disrupted, induces formation lithogenic bile. However, few studies were performed to address metabolic abnormalities underlying source excess that causes supersaturation induced by E 2 through GPR30. Of note ~50% converted acids (BA) liver each day humans and mice. Because GPR30 expressed endoplasmic reticulum not nucleus hepatocytes, we hypothesized epidermal growth...