A5062409623- Pediatric Hepatobiliary Diseases and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Hepatitis B Virus Studies
- Neurogenetic and Muscular Disorders Research
- Hepatitis C virus research
- Gastrointestinal disorders and treatments
- Intestinal Malrotation and Obstruction Disorders
- RNA modifications and cancer
- Congenital Anomalies and Fetal Surgery
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Gallbladder and Bile Duct Disorders
- Potassium and Related Disorders
- Tuberous Sclerosis Complex Research
- Congenital Diaphragmatic Hernia Studies
- Muscle Physiology and Disorders
- Renal cell carcinoma treatment
- Vaccine Coverage and Hesitancy
- Vascular Tumors and Angiosarcomas
- Periodontal Regeneration and Treatments
- IL-33, ST2, and ILC Pathways
- Intestinal and Peritoneal Adhesions
- Mitochondrial Function and Pathology
- Cellular transport and secretion
- Antibiotics Pharmacokinetics and Efficacy
Kaohsiung Medical University
2010-2024
Kaohsiung Medical University Chung-Ho Memorial Hospital
2010-2024
Chang Gung University
2003-2016
Kaohsiung Municipal Hsiao-Kang Hospital
2010-2013
National Taiwan University
2003-2006
National Taiwan University Hospital
1999-2006
Institute of Statistical Science, Academia Sinica
2006
Chang Gung Memorial Hospital
2003-2005
Memorial Hospital of South Bend
2005
Industrial Technology Research Institute
2005
Brain tumor metabolism was studied with hydrogen-1 magnetic resonance spectroscopy and positron emission tomography fluorine-18 fluorodeoxyglucose in 50 patients. N-acetylaspartate (NAA) generally decreased tumors radiation necrosis but somewhat preserved at neoplasm margins. Choline increased most solid tumors. Solid high-grade gliomas had higher normalized choline values than did low-grade (P < .02), the value not a discriminator of grade, since necrotic lesions reduced values. Serial...
Transport protein particle (TRAPP) is a multiprotein complex involved in endoplasmic reticulum-to-Golgi trafficking. Zebrafish with mutation the TRAPPC11 orthologue showed hepatomegaly steatosis and defects visual system development. In humans, mutations have been reported only three families showing limb-girdle muscular dystrophy (LGMD) or myopathy movement disorders intellectual disability.We screened genes using next-generation sequencing performed associated molecular biochemical...
The pathogenesis of biliary atresia (BA) is unclear, but epidemiological studies may help to elucidate possible causes. goals this study were identify BA incidence changes in Taiwan 2004-2009 and survey the factors that might influence causes BA.A national registry system for has been established since 2004. By using data from BA, we identified 2004-2009. We also evaluated correlations between incidences estimated rotavirus vaccine coverage rates gross domestic product.A total 185 patients...
Recurrent cholangitis may aggravate cholestatic liver cirrhosis in biliary atresia (BA) after the Kasai operation. This pilot study aimed to investigate whether Lactobacillus casei rhamnosus has prophylactic efficacy for recurrent comparison with conventional neomycin prophylaxis.Twenty jaundice-free patients BA ages 0 3 years who underwent a operation were enrolled and randomized into 2 groups 10 each: (25 mg · kg day 4 days/wk) L (8 × colony-forming unit per day) groups. The treatment...
The efficacy of hepatitis B immunoglobulin (HBIG) in infants e antigen (HBeAg)-negative surface (HBsAg) carrier mothers Taiwan is not clear.To describe the responses born to HBeAg-negative receiving HBIG combined with vaccine.Term babies were assigned based on chart number 1 2 treatment groups. Group A (n = 94) received 0.5 ml (145 IU) within 24 h birth and 3 subsequent doses recombinant virus (HBV) vaccine at 5 days, month 6 months age. 122) vaccines only. Infants 19) HBeAg-positive treated...
Objective.To investigate whether single-nucleotide polymorphisms in the promoter regions of endotoxin-responsive genes CD14 and tumor necrosis factor-α (TNF-α) are associated with biliary atresia (BA) idiopathic neonatal cholestasis (INC). Methods.We obtained genomic DNA from 90 patients established diagnosis BA 28 INC. Forty-two adult hepatitis B–related cirrhosis 143 healthy children served as control populations. The genotypes CD14/C(−159)T TNF-α/G(−308)A (G allele, TNF*1; A TNF*2) were...
Most infantile hypertrophic pyloric stenosis (IHPS) cases are diagnosed between 3 and 12 weeks after birth. Few data exist regarding Asian infants with IHPS who younger than or preterm. The goal of this study is to identify unusual clinical manifestations, course, duration hospital stay, complications preterm age.From 1991 2004, all patients admitted three tertiary centers in southern Taiwan were enrolled. stay further compared the before weeks; term infants.A total 214 enrolled into study;...
Objectives. To evaluate the long term immunity provided by a universal hepatitis B vaccination program in infancy and booster effect on school age children who had no protective antibody titers to surface antigen. Methods. We conducted community-based seroepidemiologic study of 1337 healthy 7-year-old Taiwan one decade after implementation mass program. A was suggested for noncarrier did not have antibody. Serologic responses infection rates were compared with those nonboostered children. In...
Many patients with sepsis have bacteremia for which no septic focus is identified either clinically or by autopsy. This study was designed to determine the relationship between ischemia-reperfusion injury (IRI) and bacterial translocation that might be involved in pathogenesis of necrotizing enterocolitis. In first experiment, a total 32 Sprague-Dawley rats weighing 150-200 g were divided into four groups. The mesentery isolated loop occluded 30, 60, 90 min following 30-min reperfusion three...
Aberrant congenital bands are a rare cause of acute intestinal obstruction and usually present diagnostic challenge. In 2008, the authors encountered 2 children with terminal ileal herniation. first case, it was caused by mesodiverticular band, numerous freely hanging filmy membranes attached to antimesenteric side small intestine were found concurrently; whereas, an anomalous band from distal ileum cecum leading in second case. The vascularity both herniated intestines not compromised,...
Viral infections and innate immunity signaling, especially Toll-like receptor 7 (TLR7) have been implicated in the pathogenesis of biliary atresia (BA). Administration rhesus rotavirus-type A to newborn Balb/c mice produces inflammatory obstruction bile ducts, which resembles human BA. However, whether activation TLR7 signaling plays a role neonatal hepatobiliary injury remains be investigated.TLR7 agonist, imiquimod (R837), was intraperitoneally administered within 24 hours birth then every...
The common clinical manifestations of Meckel's diverticulum include painless lower gastrointestinal bleeding and intestinal obstruction due to intussusception. Intussusception induced by inverted has rarely been reported; furthermore, there is no report thus far chronic nocturnal abdominal pain as a presenting symptom in children with diverticulum. A 4-year-and-10-month-old girl significant history previous illness presented the sole complaint for 3 months. patient was reported be...
Primary lymphomas of the gastrointestinal tract are rare, accounting for only 1 to 4% malignancies arising in stomach, small intestine, or colon. The stomach is most common extranodal site lymphoma and gastric mucosa-associated lymphoid tissue (MALT) accounts 40% primary lymphoma. Gastric MALT reaches its peak incidence between 50 60 years age, therefore, it rarely encountered pediatric population. presenting symptoms usually nonspecific perforation uncommon.A 12 year-old female presented...
Iron-deficiency anemia (IDA) affects approximately one-half of all children worldwide at some point.1 Nutritional resulting from insufficient iron intake is the most common etiology. In addition, gastrointestinal blood loss and malabsorption syndrome may cause IDA. Hiatal hernia, a frequent finding in elderly individuals, relatively rare children. It has been recognized as an important adults2,3 but overlooked etiology loss-induced IDA
This study aimed to investigate the capability of combining marrow stromal cells (MSC) and partially demineralized bone matrix (PDBM) fill defect enhance ingrowth using a canine non-weight-bearing gap model. Custom-made implants with 3 mm between porous surface host were used. The inserted into distal femurs 25 mongrel dogs gaps randomly assigned be filled culture-expanded autologous MSC-loaded PDBM, autograft, fresh-frozen allograft, PDBM alone, or nothing as controls. Histomorphometry...
The pathogenesis of necrotizing enterocolitis (NEC) is unknown. Ischemia and reperfusion (I/R) injury has been considered to be a major contributing factor. More recent reports have noted that apoptosis significant perhaps the principal contributor cell death after I/R. Some revealed infants with NEC perforated bowel can completely recover drainage alone. This study aims assess ability newborn rat intestine resist I/R compared adult intestine. Intestines from 10 groups rats (n = 6 for each...
To study the influence of clinical audit on diagnosis, complications, and factors contributing to hospitalization patients with infantile hypertrophic pyloric stenosis.Retrospective cohort study.There were 214 from 1991 2004 three medical centers in Kaohsiung. Data analyzed respect diagnostic methods, requiring patient hospitalization.The ratio male female was 4.8:1 (177 males 37 females). The diagnoses before admission as follows: 22% had milk intolerance 14.5% esophageal reflux. There a...