A5077951327- Bone Tissue Engineering Materials
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Immune Response and Inflammation
- Head and Neck Surgical Oncology
- Electrospun Nanofibers in Biomedical Applications
- Periodontal Regeneration and Treatments
- Nosocomial Infections in ICU
- Additive Manufacturing and 3D Printing Technologies
- 3D Printing in Biomedical Research
- Material Properties and Applications
- Intensive Care Unit Cognitive Disorders
- Bacterial Infections and Vaccines
- Virus-based gene therapy research
National Medical Research Center of Dentistry and Maxillofacial Surgery
2024
Research Centre for Medical Genetics
2024
V.A. Negovsky Scientific Research Institute of General Reanimatology
2020-2022
Cardiac surgery remains a field of medicine with high percentage postoperative complications, including infectious ones. Modern data indicate close relationship disorders pathological changes in the composition gut microbiome; however, extent such cardiac patients is not fully clarified. In this prospective, observational, single center, pilot study, 72 were included, 12 among them complications. We analyzed features fecal microbiota before and early period, as one markers for predicting...
The search for new potential biomarkers the diagnostics of post-neurosurgical bacterial meningitis is required because difficulties in its early verification using results routine laboratory and biochemical analyses cerebrospinal fluid (CSF). goal study was to determine contents aromatic metabolites CSF samples patients (n = 82) their diagnostical significance evaluation risk meningitis. Patients with signs 30) had lower median values glucose higher cell count, neutrophils, lactate, protein,...
The term “chronic critical illness” (CCI) refers to patients with prolonged dependence on intensive care. In most patients, CCI is triggered by severe brain injury. Ever more studies researching the microbiota in pathologic conditions are published every year, but a lot yet be elucidated about composition of gut CCI. aim this study was investigate possible correlations between changes taxonomic abundance microbiota, levels proinflammatory and neurological serum biomarkers severity central...
Background/Objectives: The replenishment of bone deficiency remains a challenging task in clinical practice. use gene-activated matrices (GAMs) impregnated with genetic constructs may be an innovative approach to solving this problem. aim work is develop collagen-based the addition platelet-rich plasma, carrying polyplexes BMP2 gene, study their biocompatibility and osteogenic potential vitro vivo. Methods: cytocompatibility materials during incubation adipose-derived stem cells (ADSCs) was...
Introduction. The development of gene-activated osteoplastic materials opens up new opportunities for effective treatment patients with bone deficiency. Materials and methods. study was carried out using multipotent mesenchymal stromal cells (MSCs) isolated from adipose tissue rats. We obtained matrices based on polylactide acid granules (PLA granules), type I collagen, fibrin that were impregnated adenovirus the BMP2 gene (Ad-BMP2) ibuprofen. Cell adhesion assessed scanning electron...
The use of 3D-printed gene-activated bone grafts represents a highly promising approach in the fields dentistry and orthopedics. Bioresorbable poly-lactic-co-glycolic acid (PLGA) scaffolds, infused with adenoviral constructs that carry osteoinductive factor genes, may provide an effective alternative to existing for reconstruction extensive defects. This study aims develop investigate properties 3D scaffolds composed PLGA carrying BMP2 gene (Ad-BMP2), both vitro vivo. elastic modulus...
3D-printing methods make it possible to fabricate matrices in accordance with the shape of substituted bone defect. The addition genetic constructs genes for osteoinductive proteins provides expression and therapeutic effect these factors area regeneration. Using anti-solvent 3D-printing, PLGA adenoviral particles carrying BMP2 gene were obtained, which have osteogenic properties vitro are promising clinical use.