A5021545911- Hepatitis C virus research
- Hepatitis B Virus Studies
- Cytomegalovirus and herpesvirus research
- Systemic Lupus Erythematosus Research
- HIV Research and Treatment
- interferon and immune responses
- Hepatitis Viruses Studies and Epidemiology
- Autophagy in Disease and Therapy
- Virus-based gene therapy research
- Poxvirus research and outbreaks
- Endoplasmic Reticulum Stress and Disease
- Viral-associated cancers and disorders
- Diabetes and associated disorders
Chan Zuckerberg Initiative (United States)
2024
Chan Zuckerberg Biohub San Francisco
2024
Université de Strasbourg
2018-2020
Inserm
2018-2020
Institute for Translational Medicine and Liver Disease
2018-2019
Institut de Biologie Moléculaire des Plantes
2019
Chronic hepatitis B virus (HBV) infection is a major cause of chronic liver disease and cancer worldwide. The mechanisms viral genome sensing the evasion innate immune responses by HBV are still poorly understood. Recently, cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS) was identified as DNA sensor. In this study, we investigated functional role cGAS in elucidate evasion. We performed studies including loss‐of‐function gain‐of‐function experiments combined with...
Objective Hepatitis D virus (HDV) is a circular RNA coinfecting hepatocytes with hepatitis B virus. Chronic results in severe liver disease and an increased risk of cancer. Efficient therapeutic approaches against HDV are absent. Design Here, we combined RNAi loss-of-function small molecule screen to uncover host-dependency factors for infection. Results Functional screening unravelled the hypoxia-inducible factor (HIF)-signalling insulin-resistance pathways, polymerase II, glycosaminoglycan...
ABSTRACT Poxviruses are a large group of DNA viruses with exclusively cytoplasmic life cycles and complex gene expression programs. A number systems-level studies have analyzed bulk transcriptome proteome changes upon poxvirus infection, but the cell-to-cell heterogeneity transcriptomic response, subcellular resolution proteomic remained unexplored. Here, we measured single-cell transcriptomes Vaccinia virus-infected populations HeLa cells immortalized human fibroblasts, resolving infection...
The Endoplasmic Reticulum (ER)-resident HSP70 chaperone BiP (HSPA5) plays a crucial role in maintaining and restoring protein folding homeostasis the ER. BiP’s function is often dysregulated cancer virus-infected cells, conferring pro-oncogenic pro-viral advantages. We explored functions during infection by Kaposi’s sarcoma-associated herpesvirus (KSHV), an oncogenic gamma-herpesvirus associated with cancers of immunocompromised patients. Our findings reveal that levels are upregulated...