A5077200796- Gut microbiota and health
- Oral microbiology and periodontitis research
- Probiotics and Fermented Foods
- Microbial Community Ecology and Physiology
- Antimicrobial Peptides and Activities
- Biosensors and Analytical Detection
- Environmental DNA in Biodiversity Studies
- Salivary Gland Disorders and Functions
- Microfluidic and Bio-sensing Technologies
- Laser Applications in Dentistry and Medicine
- Cell Image Analysis Techniques
- Innovative Microfluidic and Catalytic Techniques Innovation
- Evolution and Genetic Dynamics
- Microfluidic and Capillary Electrophoresis Applications
- Bacterial Identification and Susceptibility Testing
- Clostridium difficile and Clostridium perfringens research
- Inflammatory mediators and NSAID effects
- Pharmacogenetics and Drug Metabolism
- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
Ghent University
2020-2025
KU Leuven
2023-2024
Ecologie Microbienne Lyon
2020
Several oral diseases are characterized by a shift within the microbiome towards pathogenic, dysbiotic composition. Broad-spectrum antimicrobials often part of patient care. However, because rising antibiotic resistance, alternatives increasingly desirable. Alternatively, supplying beneficial species through probiotics is showing favorable results. Unfortunately, these rarely evaluated comparatively. In this study, in vitro effects three known and novel Lactobacillus strains, together with...
Prevention and treatment of dental caries is often achieved by fluoride mouthwashes. The most common forms are Stannous (SnF2), amine (AmF) sodium (NaF), each with differing activities against oral bacteria. Additionally, differences in microbiome between individuals linked to response the phenotype can provide information on this response. Flow cytometry successfully track microbial phenotypic heterogeneity may prove useful for capturing treatment. In study, we compared effect three...
ABSTRACT Antimicrobial resistance is one of the greatest challenges to global health. While development new antimicrobials can combat resistance, low profitability reduces number compounds brought market. Elucidating mechanism action crucial for developing antimicrobials. This become expensive as there are no universally applicable pipelines. Phenotypic heterogeneity microbial populations resulting from antimicrobial treatment be captured through flow cytometric fingerprinting. Since...
Abstract Determination of bacterial community composition in synthetic communities is critical for understanding microbial systems. The typically determined through plating or PCR-based methods which can be labor-intensive, expensive prone to bias. Simultaneously, flow cytometry has been suggested as a cheap and fast alternative. However, since the technique captures phenotypic state cells, accurate determination could affected when bacteria are co-cultured. We investigated performance...
ABSTRACT Antiseptics are widely used in oral healthcare to prevent or treat diseases, such as gingivitis and periodontitis. However, the incidence of bacteria being tolerant standard antiseptics has sharply increased over last few years. This stresses urgency for surveillance against organisms, well discovery novel antimicrobials. Traditionally, susceptibility antimicrobials is assessed by broth micro-dilution disk diffusion assays, both which time-consuming, labor-intensive, provide limited...
ABSTRACT Determination of bacterial community composition in synthetic communities is critical for understanding microbial systems. The typically determined through plating or PCR-based methods, which can be labor-intensive, expensive, prone to bias. Simultaneously, flow cytometry has been suggested as a cheap and fast alternative. However, since the technique captures phenotypic state cells, accurate determination could affected when bacteria are co-cultured. We investigated performance...
Abstract Antimicrobial resistance is one of the greatest challenges to global health. While development new antimicrobials can combat resistance, low profitability reducing number compounds brought market. Elucidating mechanism action crucial for developing antimicrobials. This process become expensive as there are no universally applicable pipelines and scientific expertise in different fields required. One way determine use predictive modeling, be classified into limited groups.. We...
Abstract Several oral diseases are characterized by a shift within the microbiome towards pathogenic, dysbiotic composition. Broad spectrum antimicrobials often part of their treatment. However, with rising antibiotic resistance, alternatives increasingly desirable. Alternatively, supplying beneficial species through probiotics is showing results, however, these rarely evaluated comparatively. In this study, in vitro effects three known- and novel lactobacillus strains, together four...
Our gut harbours around 1014 bacteria of more than 1000 species, accounting for approximately 2 kg biomass. The microbiome plays several vital functions in processes such as the development immune system, food digestion and protection against pathogens. For these to be beneficial both host microbiome, interactions are tightly regulated. Gut cells continuously interact distinguish among commensal microbiota, harmless foodstuff, A fine balance between inflammatory anti-inflammatory state is...