A5101479598- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Supramolecular Self-Assembly in Materials
- Nanoparticle-Based Drug Delivery
- Luminescence and Fluorescent Materials
- Antimicrobial Peptides and Activities
- 2D Materials and Applications
- Chemical Synthesis and Analysis
- Glycosylation and Glycoproteins Research
- Ga2O3 and related materials
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- Peptidase Inhibition and Analysis
- Click Chemistry and Applications
- Quantum Dots Synthesis And Properties
- Dendrimers and Hyperbranched Polymers
- Lipid Membrane Structure and Behavior
- Chalcogenide Semiconductor Thin Films
- Immune cells in cancer
- Perovskite Materials and Applications
National Center for Nanoscience and Technology
2020-2024
University of Chinese Academy of Sciences
2020-2024
Wuhan University of Technology
2018
Abstract The fabrication of functional assemblies with defined structures through controllable molecular packing under physiological conditions is challenging. Here, modularly designed peptide‐cyanine conjugates that intracellularly self‐assembly into 1D columnar superstructures controlled cyanine aggregation were designed, and they exhibit distinct imaging or photothermal properties. peptide backbone cleaved by caspase‐3/7 after entering the cells. Then self‐assembled residue, a double...
Up to 75% of bladder cancer patients suffer from recurrence due postoperative tumor implantation. However, clinically used Bacillus Calmette-Guerin (BCG) treatment failed inhibit the recurrence. Here, we report a bispecific glycopeptide (bsGP) that simultaneously targets CD206 on tumor-associated macrophages (TAMs) and CXCR4 cells. bsGP repolarizes protumoral M2-like TAMs antitumor M1-like mediated cytotoxicity T cell recruitment. Meanwhile, is cleaved by MMP-2 enzyme form nanostructure for...
The tumor-associated macrophages (TAMs) in intratumoral hypoxic regions are key drivers of immune escape. Reprogramming the TAMs to antitumor phenotype holds great therapeutic benefits but remains challenging for current drugs. Here, an situ activated nanoglycocluster is reported realize effective tumor penetration and potent repolarization TAMs. Triggered by hypoxia-upregulated matrix metalloproteinase-2 (MMP-2), self-assembled from administered mannose-containing precursor glycopeptides...
Targeted immunomodulation through biomolecule-based nanostructures, especially to dendritic cells (DCs), holds great promise for effective cancer therapy. However, construction of high-performance agonist by mimicking natural ligand activate immune cell signaling is a challenge so far. Here, peptide-based nanoagonist toward CD40 (PVA-CD40) with preorganized interfacial topological structure that activates lymph node DCs efficiently and persistently, achieving amplified therapeutic efficacy...
Abstract The fabrication of functional assemblies with defined structures through controllable molecular packing under physiological conditions is challenging. Here, modularly designed peptide‐cyanine conjugates that intracellularly self‐assembly into 1D columnar superstructures controlled cyanine aggregation were designed, and they exhibit distinct imaging or photothermal properties. peptide backbone cleaved by caspase‐3/7 after entering the cells. Then self‐assembled residue, a double...
Abstract Visible‐blind ultraviolet (UV) light detection has a wide application range in scenes like space environment monitoring and medical imaging. To realize miniaturized UV detectors with high performance integration ability, new device structures without bulky filters need to be developed based on advanced mechanisms. Here the unipolar barrier van der Waals heterostructure (UB‐vdWH) photodetector is reported that realizes filter‐free visible‐blind good stability, robustness,...
Abstract Cationic therapeutic peptides have received widespread attention due to their excellent antibacterial and antitumor properties. However, most of these undesirable delivery efficiency high hemolytic toxicity the positively charged α ‐helix structure containing many lysine arginine, which may restrict its in vivo applications. Herein, a conformationally transformed peptide Pep‐HCO 3 modified with bicarbonates on guanidine groups is designed. Such design allows...
Abstract Bioactive macromolecules show great promise for the treatment of various diseases. However, cytosolic delivery peptide‐based drugs remains a challenging task owing to existence multiple intracellular barriers and ineffective endosomal escape. To address these issues, herein, programmable self‐assembling peptide vectors are reported amplify cargo internalization into cytoplasm through receptor‐activated macropinocytosis. Programmable vector‐active human epidermal growth factor...
Correction for ‘pH and reduction-activated polymeric prodrug nanoparticles based on a 6-thioguanine-dialdehyde sodium alginate conjugate enhanced intracellular drug release in leukemia’ by Yanming Wan <italic>et al.</italic>, <italic>Polym. Chem.</italic>, 2018, DOI: 10.1039/c8py00577j.