A5061860784- Antifungal resistance and susceptibility
- Cancer, Hypoxia, and Metabolism
- Essential Oils and Antimicrobial Activity
- Mitochondrial Function and Pathology
- Philosophical and Cultural Analysis
- Medieval and Early Modern Iberia
- Psychological Treatments and Disorders
- Oral Health Pathology and Treatment
- Bacterial biofilms and quorum sensing
- Tannin, Tannase and Anticancer Activities
- Medieval Iberian Studies
- Philosophical Thought and Analysis
- Metabolism, Diabetes, and Cancer
- Oral and gingival health research
- Social Sciences and Policies
- Cancer-related Molecular Pathways
- Ocular Infections and Treatments
- Religious and Theological Studies
- Spanish Philosophy and Literature
- Sirtuins and Resveratrol in Medicine
- Cancer, Lipids, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Inclusive Education and Diversity
- Systemic Sclerosis and Related Diseases
- Curcumin's Biomedical Applications
University of Chile
2013-2024
University of Valparaíso
1999-2023
Faculty (United Kingdom)
2020
Valve (United States)
2019
Tumor cells principally exhibit increased mitochondrial transmembrane potential (ΔΨ(m)) and altered metabolic pathways. The therapeutic targeting delivery of anticancer drugs to the mitochondria might improve treatment efficacy. Gallic acid exhibits a variety biological activities, its ester derivatives can induce dysfunction. Four alkyl gallate triphenylphosphonium lipophilic cations were synthesized, each differing in size linker chain at cationic moiety. These selectively cytotoxic toward...
disease is one of the most neglected tropical diseases in world, affecting nearly 15 million people, primarily Latin America. Only two drugs are used for treatment this disease, nifurtimox and benznidazole. These have limited efficacy frequently induce adverse effects, limiting their usefulness. Consequently, new must be found. In study, we demonstrated vitro trypanocidal effects a series four gallic acid derivatives characterized by gallate group linked to triphenylphosphonium (TPP(+))...
Candida albicans biofilms play a key role in denture stomatitis, one of the most common oral pathologies elderly people. Because are highly resistant to antifungals, new pharmacological strategies needed. Aspirin and nitric oxide-donor molecules have both shown antibiofilm effects on C. albicans, making them promising candidates for treatment. In this study, we evaluated antifungal/antibiofilm effect nitric-oxide releasing aspirin (NO-ASA) isolates from stomatitis patients vitro. Disk...
Recurrence and resistance of Candida spp. infections is associated with the ability these microorganisms to present several virulence patterns such as morphogenesis, adhesion, biofilm formation. In search for agents antivirulence activity, essential oils could represent a strategy act against biofilms potentiate antifungal drugs.To evaluate effect Origanum vulgare L. oil (O-EO) fluconazole nystatin.The O-EO was evaluated on ATCC reference strains C. albicans non-albicans species. Minimum...
Candida albicans is the most common human fungal pathogen, and with increase in resistance rates worldwide, it necessary to search for new pharmacological alternatives. Lavandula dentata L. essential oil recognized as having antimicrobial properties. However, its effect against biofilms has been poorly described. C. albicans-related infections involve development of biofilms, which are highly resistant conventional antifungals. In this work, we evaluated antibiofilm albicans. First,...
Indomethacin is a non-selective NSAID used against pain and inflammation. Although cyclooxygenase (COX) inhibition considered indomethacin’s primary action mechanism, COX-independent ways are associated with beneficial effects in cancer. In colon cancer cells, the activation of peroxisome proliferator-activated receptor-γ (PPAR-γ) related to increase spermidine/spermine-N1-acetyltransferase-1 (SSAT-1), key enzyme for polyamine degradation, cell cycle arrest. increases SSAT-1 levels lung...
Continuous flow chemistry improves the yield of synthesis a series delocalized lipophilic triphenylphosphonium cations that induce mitochondrial dysfunction and apoptosis in head neck tumor cells.
La iniciativa Activa Valverde es un proyecto pionero y singular en la lucha contra despoblación Extremadura, tanto porque nace de sociedad civil misma, como crece hombro con Universidad. Ambos hechos explican dinámica del proceso son los que más novedosos esperanzadores nos parecen desde perspectiva su posible replicabilidad condición ejemplo para otras localidades universidades España. Burguillos pueblo Badajoz contaba años sesenta pasado siglo XX 913 habitantes, muy lejos actuales 280....
Chemoprevention can be a treatment for potentially malignant lesions (PMLs). We aimed to evaluate whether artemisinin (ART) and cisplatin (CSP) are associated with apoptosis immunogenic cell death (ICD) in vitro, using oral leukoplakia (OL) squamous carcinoma (OSCC) lines, these compounds prevent OL progression vivo.
Colorectal cancer (CRC) is the third leading cause of deaths in world. Standard drugs currently used for treatment advanced CRC-such as 5-fluorouracil (5FU)-remain unsatisfactory their results due to high toxicity, resistance, and adverse effects. In recent years, mitochondria have become an attractive target therapy higher transmembrane mitochondrial potential. We synthesized gallic acid derivatives linked a ten-carbon aliphatic chain associated with triphenylphosphonium (TPP
El articulo pretende establecer los nexos entre pensamientos de F. Nietzsche y M. Faucault: tanto desde la concepcion genealogia que subyace a ambos como tambien en consideracion filosofia diagnostico nuestro tiempo, o el problema verdad poder. cuestion del nihilismo. No obstante, no se hace abstraccion importantes elementos separan sistematicidad estilos usados por cada uno. Asi, senala Foucault privilegia las condiciones concretas existencia haciendo mayor enfasis elemento historico...
RESUMEN En este articulo se pretende esbozar un nuevo perfil de los ciudadanos, teniendo en cuenta diferentes modos organizacion hombres la sociedad, sus acciones y politicas proyecciones. Tiene tambien cuestion libertad, comunmente, esta vinculada a las transformaciones sociales que cubierta ciudad otros entornos, asi como variedad condiciones vive poblacion. Por lo tanto, historias ciudades paises plena armonia con el dificil proceso produccion ciudadanos. Palabras clave: ciudadano,...