A5081205360- Dialysis and Renal Disease Management
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Acute Kidney Injury Research
- Systemic Lupus Erythematosus Research
- Potassium and Related Disorders
- HIV/AIDS Research and Interventions
- Chronic Kidney Disease and Diabetes
- Heart Failure Treatment and Management
- Chronic Disease Management Strategies
- Muscle and Compartmental Disorders
- Frailty in Older Adults
- Blood Pressure and Hypertension Studies
- Electrolyte and hormonal disorders
- Renal and Vascular Pathologies
- Reproductive Health and Contraception
- Nutritional Studies and Diet
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Organ Donation and Transplantation
- Renal Diseases and Glomerulopathies
- Maternal and Perinatal Health Interventions
- Blood Coagulation and Thrombosis Mechanisms
- Renal cell carcinoma treatment
- Venous Thromboembolism Diagnosis and Management
Leiden University Medical Center
2017-2024
Leiden University
2022
Hospital de Sant Pau
2021
Université de Yaoundé I
2021
Bezmiâlem Vakıf Üniversitesi
2021
Obafemi Awolowo University Teaching Hospitals Complex
2021
Medisch Centrum Haaglanden
2019
University of Amsterdam
1997-2001
Amsterdam UMC Location University of Amsterdam
1997-2001
Public Risk Management Association
2001
Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a common complication of CKD; it associated with higher mortality in dialysis patients, while its impact non-dialysis patients remains mostly unknown. We investigated the associations between parathyroid hormone (PTH), phosphate calcium (and their interactions), all-cause, cardiovascular (CV) non-CV older advanced CKD.We used data from European Quality study, which includes aged ≥65 years estimated glomerular filtration rate ≤20...
For older patients with kidney failure, lowering symptom burden may be more important than prolonging life. Dialysis initiation affect individual failure-related symptoms differently, but the change in before and after start of dialysis has not been studied. Therefore, we investigated course total number starting patients.The European Quality (EQUAL) study is an ongoing, prospective, multicenter ≥65 years incident eGFR ≤20 ml/min per 1.73 m2. Using index (DSI), 30 were assessed every 3-6...
Viral populations in a human immunodeficiency virus type 1 (HIV-1)-infected individual behave as quasispecies with rated distribution of fitness variants. Fitness distributions naturally occurring viral have been difficult to study due the lack markers for clones and complicating inter- intrahost factors like presence multiple cell types distinct tropisms, differences route transmission, intervening immunity. Here, we quantitated relative vivo three subpopulations HIV-1 marked by mutations...
Sequence analysis of human immunodeficiency virus type 1 (HIV-1) from 74 persons with acute infections identified eight strains mutations in the reverse transcriptase (RT) gene at positions 41, 67, 68, 70, 215, and 219 associated resistance to nucleoside analogue zidovudine (AZT). Follow-up fate these resistant HIV-1 four newly infected individuals revealed that they were readily replaced by sensitive strains. The RT viruses changed amino acid 215 tyrosine (Y) aspartic (D) or serine (S),...
In older people with kidney failure, improving health-related quality of life is often more important than solely prolonging life. However, little known about the effect dialysis initiation on in patients. Therefore, we investigated evolution before and after starting patients failure.The European Quality study an ongoing prospective, multicenter aged ≥65 years incident eGFR ≤20 ml/min per 1.73 m2. Between April 2012 December 2021, was assessed every 3-6 months using 36-item Short-Form...
Patients with chronic kidney disease (CKD) are at a higher risk of major adverse cardiovascular events (MACE) compared the general population, but gender differences in this risk, especially older adults, not fully known. We aim to identify MACE European CKD patients, and explore factors that may explain these differences.The Quality study (EQUAL) is prospective on stage 4-5 ≥65 years old, dialysis, from Germany, Italy, Netherlands, Poland, Sweden UK. Cox regression cumulative incidence...
ABSTRACT Background A low-protein diet (LPD) is recommended to patients with advanced chronic kidney disease (CKD), whereas geriatric guidelines recommend a higher amount of protein. The aim this study was evaluate the safety LPD treatment in older adults CKD. Methods EQUAL prospective, observational including ≥65 years age an incident estimated glomerular filtration rate <20 ml/min/1.73 m2 six European countries follow-up through 6 years. Nutritional status assessed by 7-point...
ABSTRACT Because human immunodeficiency virus type 1 (HIV-1) subtypes and circulating recombinant forms (CRFs) are spreading rapidly worldwide becoming less confined to a geographical area, RNA assays that can detect quantify all HIV-1 isolates reliably in demand. We have developed fast, real-time monitored assay based on an isothermal nucleic acid sequence-based amplification technology amplifies part of the long terminal repeat region genome. Real-time detection was possible due addition...
The effect of sex on longitudinal health-related quality life remains unknown in CKD. Here we assess differences the sex-specific evolution older men and women with advanced CKD.The European Quality Study Treatment Advanced Chronic Kidney Disease is a observational prospective cohort study referred patients CKD an incident eGFR<20 ml/min per 1.73 m2 who are ≥65 years age not dialysis. Health-related was measured using 36-Item Short Form Survey at 3- to 6-month intervals between April 2012...
Hypokalemia may accelerate kidney function decline. Both hypo- and hyperkalemia can cause sudden cardiac death. However, little is known about the relationship between serum potassium death or occurrence of failure requiring replacement therapy (KRT). We investigated this in older people with chronic disease (CKD) stage 4-5.Prospective observational cohort study.We followed 1,714 patients (≥65 years old) from European Quality (EQUAL) study for 8 their first estimated glomerular filtration...
ABSTRACT To halt the human immunodeficiency virus type 1 (HIV-1) epidemic requires interventions that can prevent transmission of numerous HIV-1 subtypes. The most frequently transmitted viruses belong to subtypes A, B, and C circulating recombinant forms (CRFs) AE AG. A fast one-tube assay identifies distinguishes among CRFs AG was developed. amplifies a part gag gene sequence genome all currently known identify distinguish targeted as reaction proceeds, because addition subtype-specific...
Both hypo- and hyperkalemia can cause fatal cardiac arrhythmias. Although predialysis serum potassium level is a known modifiable risk factor for death in patients receiving hemodialysis, especially hypokalemia, this may be underestimated. Therefore, we investigated the relationship between incident hemodialysis whether there an optimum level.Prospective multicenter cohort study.1,117 (aged >18 years) from Netherlands Cooperative Study on Adequacy of Dialysis-2 study were included followed...
ABSTRACT Background We explore longitudinal trajectories of clinical indicators, patient-reported outcomes, and hospitalizations, in the years preceding death a population older patients with advanced chronic kidney disease (CKD). Methods The EQUAL study is European observational prospective cohort an incident eGFR &lt;20 ml/min per 1.73 m2 ≥65 age. evolution each indicator was explored using generalized additive models during 4 death. Results included 661 decedents median time to 2.0...
ABSTRACT Background Chronic kidney disease–associated pruritus (CKD-aP) is common in dialysis patients, and associated with lower quality of life increased risk death. We investigated the association between residual estimated glomerular filtration rate (eGFR), adequacy or serum phosphate level CKD-aP incident patients. Methods A total 1256 hemodialysis (HD) 670 peritoneal (PD) patients (&gt;18 years) from Netherlands Cooperative Study on Adequacy Dialysis (NECOSAD) study were included...
Abstract Background We explored the potential of emerging and conventional urinary kidney injury biomarkers in recipients living donor (LD) or donation after circulatory death (DCD) transplantation, patients with chronic disease (CKD), individuals from general population. Methods Urine samples allograft mild (LD; n = 199) severe (DCD; 71) ischemia-reperfusion (IRI) were analyzed for neutrophil gelatinase-associated lipocalin (NGAL), insulin-like growth factor-binding protein 7 (IGFBP7),...
Abstract Early kidney injury may be detected by urinary markers, such as beta-2 microglobulin (B2M), tissue inhibitor of metalloproteinases-2 (TIMP-2), insulin-like growth factor-binding protein 7 (IGFBP7), molecule-1 (KIM-1) and/or neutrophil gelatinase-associated lipocalin (NGAL). Of these biomarkers information on pathophysiology and reference ranges in both healthy diseased populations are scarce. Differences levels B2M, TIMP-2, IGFBP7, KIM-1 NGAL were compared 24 h before after...
The incidence rate of venous thrombosis (VT) in women switching combined oral contraceptives (COCs) is unknown.
treated with corticosteroid-pulse therapy (SP).On the patients UP<1.0g/day, 303 patents NS, 44 patinets OS, and 47 SP.RESULTS: During follow-up period, 37.1% of UP1.0g/day 11.2% UP<1.0g/day reached ESKD.With Kaplan-Meyer analysis, SP showed a significantly better prognosis in (p<0.001Chi-square), while this was not shown UP<1.0g/day.CONCLUSIONS: In long-term cohort, Corticosteroid pulse has potential to improve renal outcome IgAN eGFR<60ml/min/ 1.73m 2 UP1/day.