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Manasa Mellacheruvu

ORCID: 0000-0003-3037-2617
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About
Contact & Profiles
A5092187305
Research Areas
  • Mitochondrial Function and Pathology
  • Inflammasome and immune disorders
  • Plant Stress Responses and Tolerance
  • Cancer, Hypoxia, and Metabolism
  • Genomics, phytochemicals, and oxidative stress

The University of Queensland
 2023-2024

 NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome
OPENALEX - Publications 
J. Coombs Alina Zamoshnikova Caroline L. Holley Stephen Bradford Daniel Eng Thiam Teo and 12 more Camille Chauvin Lionel Franz Poulin Nazarii Vitak Connie Mae Petroeschevsky Manasa Mellacheruvu Rebecca C. Coll Leonhard X. Heinz Sabrina Sofia Burgener Stefan Emming Mathias Chamaillard Dave Boucher Kate Schroder

Inflammasomes are multiprotein complexes that drive inflammation and contribute to protective immunity against pathogens immune pathology in autoinflammatory diseases. assemble when an inflammasome scaffold protein senses activating signal forms a signaling platform with the adaptor ASC. The NLRP subfamily of NOD-like receptors (NLRs) includes nucleators (such as NLRP3) also NLRP12, which is genetically linked familial disorders resemble diseases caused by gain-of-function NLRP3 mutants...

10.1126/scisignal.abg8145 article EN Science Signaling 2024-01-23
 The septin modifier, forchlorfenuron, activates NLRP3 via a potassium-independent mitochondrial axis
OPENALEX - Publications 
Caroline L. Holley Stefan Emming Mercedes Monteleone Manasa Mellacheruvu Kirsten M. Kenney and 4 more Grace Lawrence J. Coombs Sabrina Sofia Burgener Kate Schroder

10.1016/j.chembiol.2024.04.012 article EN Cell chemical biology 2024-05-01
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