About
Contact & Profiles
A5054410769
Research Areas
- Cholesterol and Lipid Metabolism
- Peroxisome Proliferator-Activated Receptors
- Nuclear Receptors and Signaling
University of Oklahoma
2023
Oxysterol-binding protein (OSBP) and OSBP-related 4 (ORP4) have emerged as potentially druggable targets in antiviral precision cancer drug development. Multiple structurally diverse small molecules function through targeting the OSBP/ORP family of proteins, including steroidal compounds OSW-1 T-00127-HEV2. Here, structure–activity relationships oxysterols related compound binding to human OSBP ORP4 are characterized. Oxysterols with hydroxylation at various side chain positions (i.e., C-20,...
10.1021/acs.jmedchem.2c01025
article
EN
Journal of Medicinal Chemistry
2023-03-14
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