A5014974468- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Cellular transport and secretion
- Metabolism and Genetic Disorders
- RNA modifications and cancer
- Nerve injury and regeneration
- Mitochondrial Function and Pathology
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- RNA and protein synthesis mechanisms
University of Florida
2021-2023
Pathophysiological damages and loss of function dopamine neurons precede their demise contribute to the early phases Parkinson's disease. The presence aberrant intracellular pathological inclusions protein α-synuclein within ventral midbrain dopaminergic is one cardinal features We employed molecular biology, electrophysiology, live-cell imaging investigate how excessive expression alters multiple characteristics neuronal dynamics transmission in cultured conditionally expressing GCaMP6f....
Dysregulation of dopamine neurotransmission profoundly affects motor, motivation and learning behaviors, can be observed during the prodromal phase Parkinson's disease (PD). However, mechanism underlying these pathophysiological changes remains to elucidated. Mutations in vacuolar protein sorting 35 (VPS35) leucine-rich repeat kinase 2 (LRRK2) both lead autosomal dominant PD, VPS35 LRRK2 may physically interact govern trafficking synaptic cargos within endo-lysosomal network a...
Abstract Recent studies show that mutations in DNAJC12 , a co-chaperone for monoamine synthesis may cause mild hyperphenylalaninemia with infantile dystonia, young-onset parkinsonism, developmental delay and cognitive deficits. To this end, gene has been included newborn screening, most revealingly Spain, those results are testament to the importance of early diagnosis treatment combating human diseases. However, practitioners be unaware these advances it is probable many patients,...
Abstract Dysregulation of dopamine neurotransmission profoundly affects motor, motivation and learning behaviors, is often observed during the prodromal phase Parkinson’s disease (PD). However, mechanism underlying these pathophysiological changes remains to be elucidated. Mutations in vacuolar protein sorting 35 ( VPS35 ) leucine-rich repeat kinase 2 LRRK2 both lead autosomal dominant PD, may physically interact govern trafficking synaptic cargos within endo-lysosomal network a...