A5057177519- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer Treatment and Pharmacology
- Hemoglobinopathies and Related Disorders
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Clostridium difficile and Clostridium perfringens research
- Neutropenia and Cancer Infections
- Hematological disorders and diagnostics
- vaccines and immunoinformatics approaches
- COVID-19 and healthcare impacts
- Pharmacological Effects and Toxicity Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Complement system in diseases
- Autoimmune and Inflammatory Disorders Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Influenza Virus Research Studies
- Cancer survivorship and care
- Nosocomial Infections in ICU
- Platelet Disorders and Treatments
- Histone Deacetylase Inhibitors Research
- Cancer therapeutics and mechanisms
Rochester General Hospital
2015-2025
Unity Health System
2018-2025
Armed Forces Institute of Pathology
2025
University of Miami
2019
Research Network (United States)
2011
Georgetown University
2008-2010
National Cancer Institute
2009
Cleveland Clinic
2009
Vince Lombardi Cancer Clinic
2008
University of Rochester
2007
BackgroundHaemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening syndrome characterized by an excessive inflammatory response. Limited data exist on adult HLH.MethodsIn this national, retrospective cohort study, we analysed from the US National Inpatient Sample database collected between October 1, 2006 December 31, 2019. Using International Classification of Diseases (ICD) codes, identified all patients who were admitted non-electively with diagnosis HLH. We described...
Immunocompromised individuals with hematological malignancy have increased risk for poor outcomes and death from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This special population may mount a suboptimal response to vaccination. We assessed the effectiveness of tixagevimab cilgavimab (Evusheld), monoclonal antibody combination against SARS-CoV-2, in conjunction standard preventative measures, at preventing symptomatic incident infection.Patients aged 18 years older...
Introduction Rare bleeding disorders (RBDs) result from genetic mutations in clotting factors. These RBDs vary prevalence and are often underdiagnosed due to mild symptoms. Treatment is challenging limited clinical data primarily involves substituting deficient factors using adjuvant therapies. Women with face unique risks, including gynecologic bleeding, hemorrhagic ovarian cysts, complications during pregnancy. issues can significantly impact their quality of life employment. This study...
e19083 Background: Infection is a significant cause of morbidity & mortality in patients with chronic lymphocytic leukemia (CLL), lymphoma, multiple myeloma (MM). As evaluation for immunodeficiency heterogeneous, we conducted study to proactively assess humoral function. Methods: We enrolled 91 CLL, or MM, all ≥18 years age. Patients were excluded if they had undergone transplant within 6 months known immunodeficiency. evaluated by checking immunoglobulin (Ig) levels response...
Infections are a major cause of morbidity and mortality in individuals with multiple myeloma (MM). These exhibit humoral dysfunction show suboptimal response to pneumococcal polysaccharide vaccine (PPV23). Since conjugate (PCV13) elicits T cell dependent response, it is recommended patients myeloma. This study compares the initial PCV13 durability at 6 months versus normal controls. Seven 18 control were enrolled study. Streptococcal pneumonia serotype IgG titers drawn baseline, day 30, 180...
Summary Novel agents have provided a new foundation for multiple myeloma therapies. When combined with other anti‐myeloma agents, these compounds significantly enhance clinical efficacy. High‐dose steroids are frequently used in combination regimens; however, the doses employed often poorly tolerated, especially patients concurrent comorbid conditions. We hypothesized that steroid‐independent regimen could be developed without significant compromise of The availability such will important...
Hemophagocytic lymphohistiocytosis (HLH) is a rare and serious hematologic disorder characterized by severe immune system dysregulation with cytokine storm histologic evidence of hemophagocytosis. It can be inherited or develop secondary to other diseases. We present three cases HLH in patients distinct backgrounds. Our objective characterize the unique features disease, its underlying associations, treatment, potential prognostic variables. The first case was 20-year-old male history...
Thrombotic thrombocytopenic purpura (TTP) commonly affects women of childbearing age. Although cases TTP in pregnancy have been reported, the pathology placenta has not described. In other organs, a distinctive arteriolar aneurysms with segmental intramural hyaline deposits. Published many decades ago, these classic papers antedate modern computerized literature searches, so this information included reviews on TTP. We report 2 pregnancy, both leading to fetal loss 2nd trimester. noticed...
e18558 Background: PAN, a potent histone deacetylase inhibitor, significantly inhibits the growth of MM cells in vitro and enhances cytotoxicity standard chemotherapy. Studies with our SCID-hu models show an increased inhibition cell when PAN was combined MEL compared to treatment either drug alone. These preclinical studies provided rationale for evaluating combination oral patients R/R disease. Methods: This Phase 1/2, open-label, dose‑escalation study treat initially using every Monday,...
Background Patients with chronic lymphocytic leukemia (CLL) experience hypogammaglobinemia and non-neutropenic infections. In this exploratory proof of concept study, our objective was to determine the prevalence humoral immunodeficiency in patients CLL serum IgG ≥ 400 mg/dL, evaluate efficacy subcutaneous immunoglobulin (SCIG) population. methods mg/dL were evaluated for IgG, IgM, IgA, along pre/post vaccine titers diphtheria, tetanus, Streptococcus pneumoniae . evidence dysfunction treated...
Thrombotic thrombocytopenic purpura (TTP) can often be life threatening and requires timely diagnosis prompt initiation of plasmapharesis. Cobalamin deficiency closely mimic TTP distinguishing between the two diseases prove to a diagnostic challenge. Previously, cobalamin-related pseudo-TTP has been associated with pernicious anemia, dietary insufficiency hereditary disorders cobalamin activation. Here in, we discuss first case suspected metformin-induced causing pseudo-TTP. Our patient was...
6558 Background: The combination of fludarabine (F) and rituximab (R) has shown an ORR 90% (CR 47%) in pts with untreated CLL. Nevertheless, relapse is inevitable. Lenalidomide (L) 32-47% 7-9%) relapsed/refractory Therefore, we proposed following FR L monotherapy CLL order to improve the CR rate PFS. Methods: For this 2-stage Phase II study, requiring therapy, a performance status < 2, adequate organ function were eligible. Pts received R 375 mg/m2 IV on D1 F 25 D1-5 for 3 cycles. CR/PR more...
Abstract Long‐term use of hydroxyurea can cause leg ulcers which usually do not heal unless the drug is discontinued. Patients should be counseled regarding alternative lines treatment like anagrelide and pegylated‐interferon.
e23215 Background: Infectious complications are the leading cause of morbidity and mortality in patients with chronic lymphocytic leukemia(CLL) multiple myeloma(MM). Despite recognized risks, evaluation immune function occurs inconsistently. Our retrospective study evaluated practice patterns for assessing secondary immunodeficiency (SID) newly diagnosed CLL MM patients. aim is to identify areas improvement guide future prospective studies. Methods: We analyzed various parameters at...
In the era of novel agents, Bruton tyrosine kinase (BTK) inhibitors have changed dynamics treating chronic lymphocytic leukemia. However, small studies shown conflicting results regarding additive humoral dysfunction with their use.We prospectively compared vaccine responses in patients on ibrutinib (n = 10) matched controls 16) and analyzed whether a protein-based (tetanus-diphtheria toxoid) or carbohydrate (Pneumovax) moiety will result an improved immunological response.An appropriate...
e23060 Background: Essential thrombocythemia (ET) is a myeloproliferative neoplasm. Thrombosis major cause of morbidity and mortality in ET. It unknown whether the ischemic stroke ET different from that non-ET patients. Similarly, quantitative data regarding use platelet pheresis this population also unknown. This National Inpatient Sample (NIS) database study aims to answer these questions. Methods: A retrospective analysis NIS 2016 2020 was conducted using ICD-10 codes identify...
12071 Background: The opioid crisis is a growing public health concern in the United States. In this retrospective study, we aim to look at trends and predictors of overdose-related mortality cancer patients. Methods: A analysis National Inpatient Sample database (NIS) from 2016 2020 was conducted using International Classification Diseases-10(ICD-10) codes identify hospitalizations related overdose. 2016-2020 mark chosen because first NIS year with full implementation ICD-10 code there...