A5020317025- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Sperm and Testicular Function
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Garlic and Onion Studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Selenium in Biological Systems
- Reproductive Biology and Fertility
- Synthesis and biological activity
- Chemotherapy-induced organ toxicity mitigation
- Organophosphorus compounds synthesis
- Medicinal Plants and Bioactive Compounds
- Chemotherapy-induced cardiotoxicity and mitigation
- Thyroid Cancer Diagnosis and Treatment
- Synthesis and Characterization of Heterocyclic Compounds
- Noise Effects and Management
- Metal complexes synthesis and properties
- Phytochemicals and Antioxidant Activities
- Dye analysis and toxicity
- Medicinal Plants and Neuroprotection
- Drug-Induced Hepatotoxicity and Protection
- Pain Mechanisms and Treatments
- Antioxidant Activity and Oxidative Stress
- Head and Neck Cancer Studies
- Pharmacological Effects of Natural Compounds
Tunis University
2014-2024
Tunis El Manar University
2012-2024
Faculté de médecine de Tunis
2014-2024
Hôpital La Rabta
2011
Institut Salah-Azaïz
1994-1997
Environmental exposures to Cadmium (Cd) are a major cause of human toxicity. The kidney is the most sensitive organ; however, natures injuries and adaptive responses have not been adequately investigated, particularly in response environmental relevant Cd concentrations. In this study, rats received daily ip injection low CdCl2 dose (0.3 mg Cd/Kg body mass) killed at 1, 3, 5 days intoxication. Functional, ultrastructural, biochemical observations were used evaluate effects. We show that such...
This study was conducted to evaluate the effects of e-cigarette refill liquid administration alone or with nicotine on antioxidant defense status, functional and histopathological changes in adult rat liver tissue. For this purpose, 32 rats were treated for 28 days as follows: control group injected intra-peritoneally physiological saline; 0% received an intra-peritoneal injection e-liquid without diluted saline, e-cigarette-treated containing 0.5 mg nicotine/kg body weight/day saline...
Abstract Background Garlic or Allium sativum (As) shows therapeutic effects such as reduction of blood pressure hypercholesterolemia but side-effects on reproductive functions remain poorly investigated. Because garlic's chemical complexity, the processing methods and yield in preparations differ efficacy safety. In this context, we clarify mechanisms action crushed crude garlic testicular markers. Methods During one month treatment, 24 male rats were fed 5%, 10% 15% garlic. Results We...
to investigate the effects of crude garlic on adult male rat reproductive functions.Thirty rats were divided into five groups: group 1 (untreated) and groups 2, 3, 4 5 fed for 30 days with 5%, 10%, 15% 30% garlic, respectively. Testes accessory organs weighed some markers assessed. Light electron microscopy observations also performed.A significant decrease was observed in body weight (14%; P < 0.01) (20%; 0.01); prostate (29.1%; 0.05) seminal vesicle 3 (14.4%; 0.01), (18.3%; (27.3%; 0.01)....
The Juglans regia root aqueous extract (JRRAE) phytochemical variability and the investigation of their antimicrobial, antibiofilm, insecticidal, anti-leishmanial properties were studied. As a result, JRRAE chemical profile revealed presence biomolecules using UV, HPLC, FT-IR analysis. investigations showed marked antibacterial activities, highlighted inhibited biofilm formation, induced lethality Leishmania amazonensis promastigotes (50%), possess an insecticidal activity at 100 µg/ml. A...
Abstract Aim The objective is to report the correlation between pathology and molecular subtype classifications of breast cancer in Tunisian women. Methods This retrospective study concerned data 966 cases collected from 2007 2009 at S alah A zaiz I nstitute T unis. These were classified by an immunohistochemistry test for estrogen progesterone receptors human epidermal growth factor receptor 2 (HER2) status four subtypes, namely luminal , B HER2+ triple negative. correlated with...
Arsenic is a metalloid found in water, soil, and air from natural anthropogenic sources, commonly inorganic as well organic forms. The clinical use of arsenic trioxide (As 2 O 3 ) the treatment acute promyelocytic leukemia (APL) limited by its cardiotoxic side effects. Grape seed skin extract (GSSE) polyphenolic mixture with antioxidant properties. This study aimed to evaluate protective effect GSSE on arsenic-induced cardiac oxidative stress injury. Animals exposed 2.5 mg/kg As for 21 days...
Obesity is a public health problem that contributes to morbidity and mortality from diabetes, heart disease, stroke, cancers. The purpose of this investigation was analyse the link between obesity-induced oxidative stress, renal steatosis, kidney dysfunction, as well protective effect grape seed skin extract. Rats were fed standard diet or high-fat for 6 weeks either treated not with Fat-induced stress evaluated in special emphasis on transition metals. High-fat induced triglyceride...
The role of IGF-1 in promoting cancer has been investigated for many years. aim this study is to explore the relationship between rates and NPC evaluate association with clinical parameters.IGF-1 levels was measured by Elisa test among 82 patients 60 healthy controlsOur results showed, first time, a significant increased IGF-I comparison controls (p<0.01). According age, sex tumor size patients, we demonstrated that concentrations are significantly higher aged over 30 years compared less...
Hypericum genus is traditionally known for its medicinal use and therapeutic antioxidant effects. However, the toxic effect of this plant has not been much explored. Our study aimed at investigating humifusum (Hh) leaf extracts on oxidative stress parameters in male rats. For it, we first focused phytochemical analysis aqueous methanolic Hh leaves. Hence, Wistar rats were treated per gavage 30 days divided into Control (1 mL/rat, distilled water), A200 group (200 mg/kg body weight (bw)...
Indoor air radon concentrations are still unknown in Tunisia. For the first time, they have been determined several regions of country using open alpha track dosi-meters containing LR-115 film. Measurements were taken 69 dwellings located around greater Tunis during 1 y, changing dosimeters every 2 mo. In 12 other locations, devices placed winter months. The median 1,217 measurements was 40 Bq m−3 and 93.4% them less than 100 m−3. highest concentration 392 Tunis, higher winter. figures...