A5059843609- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Respiratory viral infections research
- Antimicrobial Resistance in Staphylococcus
- vaccines and immunoinformatics approaches
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- COVID-19 and healthcare impacts
- Vasculitis and related conditions
- Virus-based gene therapy research
- Cancer Diagnosis and Treatment
- Bacillus and Francisella bacterial research
- Antibiotic Use and Resistance
- Microbial Metabolism and Applications
- Pulmonary Hypertension Research and Treatments
- COVID-19 diagnosis using AI
- Bacterial biofilms and quorum sensing
- Economic and Financial Impacts of Cancer
- Diabetic Foot Ulcer Assessment and Management
- Pressure Ulcer Prevention and Management
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Wound Healing and Treatments
- Antifungal resistance and susceptibility
MedStar Georgetown University Hospital
2023
Georgetown University
2022-2023
Creative Commons
2023
Center for Discovery
2020-2022
Hackensack Meridian Health
2020-2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs), harboring spike protein N-terminal domain (NTD) or receptor-binding (RBD) mutations, exhibit reduced in vitro susceptibility to convalescent-phase serum, commercial antibody cocktails, and vaccine neutralization have been associated with reinfections. The accumulation these mutations could be the consequence intrahost viral evolution due prolonged infection immunocompromised hosts. In this study, we...
The devastation caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made clear the importance of pandemic preparedness. To address future zoonotic outbreaks due to related viruses in sarbecovirus subgenus, we identified a human monoclonal antibody, 10-40, that neutralized or bound all sarbecoviruses tested vitro and protected against SARS-CoV-2 SARS-CoV vivo. Comparative studies with other receptor-binding domain (RBD)–directed antibodies showed 10-40 have greatest...
Staphylococcus aureus sequence type 9 (ST9) is the main LA-MRSA clone spreading in Asian continent. It can colonize and cause mild to severe infections both animal humans.
Abstract New Jersey was an early epicenter for the COVID-19 pandemic in United States, yet information on hospitalized patients from this area is scarce. This study aimed to provide data demographics and clinical features of a patient population who were confirmed with infection by our in-house (CDI) real-time reverse-transcription polymerase chain reaction (RT-PCR) test. We included consecutive admitted Hackensack Meridian Health system hospitals laboratory-confirmed diagnoses at University...
Abstract SARS-CoV-2 Variants of Concerns (VOC), e.g., B.1.351 (20H/501Y.V2) and P1 (20J/501Y.V3), harboring N-terminal domain (NTD) or the receptor-binding (RBD) (e.g., E484K) mutations, exhibit reduced in vitro susceptibility to convalescent serum, commercial antibody cocktails, vaccine neutralization, have been associated with reinfection. The accumulation these mutations could be consequence intra-host viral evolution due prolonged infection immunocompromised hosts. In this study, we...
Examining the neutralizing capacity of monoclonal antibodies (MAbs) used to treat COVID-19, as well recovered from unvaccinated, previously vaccinated, and infected individuals, against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants concern (VOCs) remains critical study. Here, we report on a SARS-CoV-2 nosocomial outbreak caused by R.1 variant harboring E484K mutation in 281-bed psychiatric facility New Jersey among unvaccinated inpatients health care professionals...
Fungal infections are common complications of respiratory viral and associated with the increased need for intensive care elevated mortality. Data regarding microbiological molecular characteristics such in COVID-19 patients scarce. Here, we performed a comprehensive analysis, including species identification, antifungal susceptibility testing, resistance determinants typing, retrospective clinical data review, fungal isolates recovered from 19 patients, who were hospitalized at Hackensack...
Abstract The devastation caused by SARS-CoV-2 has made clear the importance of pandemic preparedness. To address future zoonotic outbreaks due to related viruses in sarbecovirus subgenus, we identified a human monoclonal antibody, 10-40, that neutralized or bound all sarbecoviruses tested vitro and protected against SARS-CoV vivo . Comparative studies with other receptor-binding domain (RBD)-directed antibodies showed 10-40 have greatest breadth thus its promise as an agent for Moreover,...
Emergence of SARS-CoV-2 with high transmission and immune evasion potential, the so-called variants concern (VOC), is a major concern. We describe early genomic epidemiology recovered from vaccinated health care professionals (HCP). Our postvaccination COVID-19 symptoms-based surveillance program among HCPs in 17-hospital network identified all who tested positive for after routine screening or self-reporting. From 1 January 2021 to 30 April 2021, 23,687 received either mRNA-1273 BNT162b2...
ABSTRACT Spike protein mutations E484K and N501Y carried by SARS-CoV-2 variants have been associated with concerning changes of the virus, including resistance to neutralizing antibodies increased transmissibility. While are fast spreading in various geographical areas, identification monitoring these is lagging far behind, due large part slow speed insufficient capacity viral sequencing. In response unmet need for a efficient screening tool, we developed single-tube duplex molecular assay...
ABSTRACT Emergence of SARS-CoV-2 with high transmission and immune evasion potential, the so-called Variants Concern (VOC), is a major concern. We describe early genomic epidemiology recovered from vaccinated healthcare professionals (HCP). Our post-vaccination COVID-19 symptoms-based surveillance program among HCPs in 17-hospital network, identified all HCP who tested positive for after routine screening or self-reporting. From 01/01/2021 to 04/30/2021, 23,687 received either mRNA-1273...
PURPOSE: The COVID-19 pandemic restricted non-emergent surgery and increased time-to-surgery (TSS). Resultant changes in medical surgical breast cancer treatment during this time warrant further characterization to optimize care. Our study aims assess the implications of on progression (tumor, nodal, metastasis) TNM stage patients surgically treated for primary cancer. METHODS: This multicenter observational includes 1,215 receiving oncologic before (January 2018-December 2019; 'pre-COVID')...
ABSTRACT Background New Jersey was an early epicenter for the COVID-19 pandemic in United States, yet information on hospitalized patients from this area is scarce. This study aimed to provide data demographics and clinical features of a patient population who were confirmed with infection by our in-house (CDI) real-time reverse-transcription polymerase chain reaction (RT-PCR) test. Methods We included consecutive admitted Hackensack Meridian Health system hospitals laboratory-confirmed...