A5003011337- Antibiotic Resistance in Bacteria
- CRISPR and Genetic Engineering
- Mycobacterium research and diagnosis
- RNA modifications and cancer
- Ion-surface interactions and analysis
- HVDC Systems and Fault Protection
- Boron and Carbon Nanomaterials Research
- RNA Interference and Gene Delivery
- Asthma and respiratory diseases
- Metal and Thin Film Mechanics
- Advanced biosensing and bioanalysis techniques
- Microstructure and mechanical properties
- Genomics and Phylogenetic Studies
- Circular RNAs in diseases
- X-ray Spectroscopy and Fluorescence Analysis
- Lipid metabolism and biosynthesis
- Pneumonia and Respiratory Infections
- IL-33, ST2, and ILC Pathways
- Bacterial Genetics and Biotechnology
- Silicon and Solar Cell Technologies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Microgrid Control and Optimization
- RNA and protein synthesis mechanisms
- Plant Stress Responses and Tolerance
- Plant responses to water stress
Northwest A&F University
2021-2025
Gansu Academy of Agricultural Sciences
2025
Hainan Medical University
2023-2024
Hainan General Hospital
2023-2024
Fudan University
2008-2023
State Key Laboratory of Surface Physics
2022-2023
Shanxi Medical University
2018-2022
First Hospital of Shanxi Medical University
2018-2022
Huashan Hospital
2008-2009
N6 -methyladenosine (m6 A) reader protein plays an important role in trichome morphology, developmental timing and morphogenesis Arabidopsis. However, the function of m6 A readers plant-microbe interaction remains unclear. Here, a Malus YTH-domain family MhYTP2 was initially characterized as reader. overexpression increased mRNA modification level translation efficiency. The exon regions appeared to destabilize mRNAs, whereas untranslated positively correlated with associated abundance....
Klebsiella pneumoniae carbapenemase (KPC)-producing K. (KPC-KP) have disseminated worldwide and emerged as major threats to public health. Of epidemiological significance, the international pandemic of KPC-KP is primarily associated with CG258 isolates blaKPC-IncF plasmids. CRISPR-Cas system an adaptive immune that can hinder gene expansion driven by horizontal transfer. Because plasmids are favored pneumoniae, it was interest examine co-distribution CRISPR in such isolates. We collected 459...
Studies have shown that the m6A reader primarily affects genes expression by participating in regulation of mRNA localization, splicing, degradation, translation, and other metabolic processes. Previously, we discovered apple (Malus domestica) MhYTP2 bound with destabilized m6A-modified MdMLO19 mRNA. In addition, it enhanced translation efficiency MdGDH1L, encoding a glutamate dehydrogenase, which confers resistance to powdery mildew. this study, report function low nitrogen (N). The...
Purpose: Chronic obstructive pulmonary disease (COPD) is a common respiratory disorder. Pyroptosis represents distinctive form of inflammatory cell death that mediated through the activation Caspase-1 and inflammasomes. CircRNAs have emerged as novel class biomolecules with implications in various human diseases. This study aims to investigate circRNAs profile COPD progression identify pivotal associated development this disease. Methods: he expression profiles peripheral blood mononuclear...
ABSTRACT Hypoxia is one of the main challenges in apple ( Malus domestica ) cultivation. However, breeding hypoxia‐tolerant cultivars demands a thorough understanding responses trees to low oxygen supply. Studies have indicated that N 6 ‐methyladenosine (m A) reader regulates plant stress response by binding their corresponding mRNA targets with m A modification. The present study investigated function and mechanism MhYTP2 under hypoxia stress. Here, we found overexpression improved...
Neutron conversion detectors that use 10B-enriched boron carbide are feasible alternatives to 3He-based detectors. We prepared films at micron-scale thickness using direct-current magnetron sputtering. The structural characteristics of natural B4C films, including density, roughness, crystallization, and purity, were analyzed grazing incidence X-ray reflectivity, diffraction, photoelectron spectroscopy, time-of-flight secondary ion mass spectrometry, scanning electron microscopy. A beam...
Mycoplasma pneumoniae is a highly infectious bacterium and the major cause of pneumonia especially in school-going children. affects respiratory tract, 25% patients experience health-related problems. It important to have suitable method detect M. pneumoniae, gold nanoparticle (GNP)-based colorimetric biosensing was used this study identify specific target DNA for pneumoniae. The color GNPs changes due negatively charged presence positively monovalent (Na+ ) ions from NaCl. This condition...
Chronic obstructive pulmonary disease (COPD) is a complex disease, and its pathogenesis influenced by genetic factors. This study aimed to evaluate the role of IL5RA variation in risk COPD. In this study, 498 patients with COPD normal controls were recruited. Subsequently, five SNPs (rs3804795, rs2290610, rs13097407, rs334782, rs3856850) gene genotyped. Logistic analysis examined association single nucleotide polymorphisms (SNPs) under various models. Furthermore, between susceptibility was...
Abstract Since the growth morphology along and perpendicular to interface is important for supermirror applications, dependence of this on reactive gas has been investigated in Ni/Ti multilayers prepared by magnetron sputtering with variable O 2 /N ratios. The properties are characterized GIXRR, XDS, TEM measurements. Compared case without , presence 20% deposition Ni layers contributes smooth abrupt interfaces. It also suppresses accumulation interfacial roughness increasing number layers....
Background The chronic respiratory condition known as obstructive pulmonary disease (COPD) was one of the main causes death and disability worldwide. This study aimed to explore elucidate new targets molecular mechanisms COPD by constructing competitive endogenous RNA (ceRNA) networks. Methods GSE38974 GSE106986 were used select DEGs in samples normal samples. Cytoscape software construct present protein-protein interaction (PPI) network, mRNA-miRNA co-expression network ceRNA network....
Background Chronic obstructive pulmonary disease (COPD) is a progressive respiratory that severely impairs patients' function and quality of life. RARB involved in COPD progression by affecting inflammatory reactions, cell proliferation, apoptosis. The impact single nucleotide polymorphisms (SNPs) within on susceptibility remains unclear. Here, we aimed to evaluate the association between SNPs risk.
Objective To observe the integration frequency of aadA2 resistance cassette at attI site integron under different concentration streptomycin. Methods Class 1 with known gene sequence was cloned into plasmid pACYC184 to produce recombinant pACIDA, meanwhile integrase pET28a construct pETINT. These two plasmids were consecutively transformed E. coli BL(DE3). bacteria cultured in LB medium 37 ℃ overnight addition The copy number total integrons and integrated determined by using...