A5063054034- Bone health and osteoporosis research
- Bone health and treatments
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Vitamin D Research Studies
- Pelvic and Acetabular Injuries
- Multiple Myeloma Research and Treatments
- Hip and Femur Fractures
- Bone and Joint Diseases
- Prostate Cancer Treatment and Research
- Parathyroid Disorders and Treatments
- Curcumin's Biomedical Applications
- Trace Elements in Health
- Bone Metabolism and Diseases
- Thyroid Disorders and Treatments
- Pituitary Gland Disorders and Treatments
- Medical Imaging and Pathology Studies
- Retinoids in leukemia and cellular processes
- Chronic Lymphocytic Leukemia Research
- Cancer Diagnosis and Treatment
- Nutrition and Health in Aging
- Drug Transport and Resistance Mechanisms
- Vitamin C and Antioxidants Research
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Research
St George Hospital
2013-2023
St. George Hospital
1997-2023
UNSW Sydney
2003-2023
Sutherland Hospital
2016-2019
St George's Hospital
1996-2015
New South Wales Department of Health
2015
University of Wollongong
2009
Sabin Vaccine Institute
2009
Royal North Shore Hospital
1989-2007
The University of Sydney
2007
To determine the prevalence of vitamin D deficiency in pregnant women and their neonates to examine factors associated with deficiency.Population-based study from South-eastern Sydney, Australia.Serum 25 hydroxy-vitamin (25-OHD), PTH, calcium, albumin, phosphate alkaline phosphatase were measured at 23-32 weeks gestation on cord blood delivery. Maternal skin phototype was recorded using Fitzpatrick scale.Vitamin (defined as 25-OHD <or= nmol/l) found 144 971 (15%) 98 901 (11%) neonates....
Androgen receptor blocking agents have become an established form of therapy for men with disseminated prostate carcinoma. The purpose this study was to evaluate markers bone turnover and measure mineral densities (BMD) in carcinoma treated combined androgen blockade prior after 6 months intermittent cyclic etidronate therapy.Twelve consecutive were evaluated at 0, 6, 12 treatment a long acting gonadotropin-releasing hormone agonist (goserelin acetate) antagonist (flutamide). During the 6-12...
To assess the safety and efficacy of percutaneous vertebroplasty for treatment acute osteoporotic vertebral fractures.A prospective, non-randomised, "intention-to-treat" 2-year study.126 consecutive patients (39 men 87 women, aged 51-95 years) with fractures presenting to St George Hospital from November 2000 December 2002. They comprised 88 treated by 38 conservative therapy.Primary outcomes--changes in patients' pain score level function recorded at 24 hours, 6 weeks, 6-12 months after...
A significant number of Australians are deficient in vitamin D — it is a fallacy that receive adequate from casual exposure to sunlight. People at high risk deficiency include elderly people (particularly those residential care), with skin conditions where avoidance sunlight advised, dark if veiled), and malabsorption. Exposure hands, face arms one-third minimal erythemal dose (MED) (the amount produces faint redness skin) most days recommended for endogenous synthesis. However, deliberate...
Abstract BACKGROUND Prostate carcinoma therapy with combined androgen blockade may result in high bone-turnover significant bone loss. This study was undertaken to evaluate the antiosteoporotic efficacy of intravenous pamidronate a double blind, randomized, placebo-controlled, crossover study. METHODS Twenty-one consecutive men metastatic prostate who were receiving long-acting gonadotropin-releasing hormone agonist (gosarelin acetate) and an antagonist (flutamide or bicalutamide) evaluated...
Study Objective: To define the prevalence, severity, type and pathogenesis of osteopenia in idiopathic hemochromatosis. Design: Prospective study conducted over 18 months. Setting: Tertiary care center. Subjects: Twenty-two men with hemochromatosis 20 age-matched controls. There were 5 hypogonadal patients, 9 eugonadal nonvenesected 8 venesected patients. Measurements Main Results: All patients controls evaluated by spinal radiography, fore-arm bone mineral density estimations, dynamic...
The incidence and etiology of falls in patients following hip fracture remains poorly understood. We prospectively investigated the of, risk factors for, recurrent injurious community-dwelling persons admitted for surgical repair minimal-trauma fracture. Fall surveillance methods included phone calls, medical records, fall calendars. Potential predictors health status, quality life, nutritional body composition, muscle strength, range motion, gait velocity, balance, walking endurance,...
To measure spinal and peripheral bone mineral densities in patients with acromegaly.Retrospective study.Tertiary care center.Twenty-four acromegaly 24 case controls. Seventeen (12 eugonadal 5 hypogonadal) had "active" disease as indicated by elevated plasma concentrations of growth hormone or somatomedin C both at the time study. Seven (all inactive these criteria.Bone was measured single photon absorptiometry forearm dual spine. The content active disease, regardless gonadal status,...
Aim: To evaluate the efficacy and safety of an annual intramuscular injection cholecalciferol for vitamin D deficiency. Design: Prospective open-label study. Participants: Five men 45 women (mean age 66.3 years) with deficiency who were given a single therapeutic 600 000 IU (15 mg) (vitamin D3). Outcome measures: Serum levels calcium, creatinine, 25-hydroxyvitamin D3 (25OHD3) parathyroid hormone, as well early morning 2-hour urine calcium/creatinine excretion index. Specimens collected at...
Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) represent useful models for studying precursor disease, developing early intervention strategies. Administering a 4g dose curcumin, we performed randomised, double-blind placebo-controlled cross-over study, followed by an open-label extension study using 8g to assess the effect curcumin on FLC response bone turnover in patients with MGUS SMM. 36 (19 17 SMM) were randomised into two groups: one...
Objective: To measure changes in spinal and femoral neck bone mineral densities patients treated for Graves thyrotoxicosis. Design: Cohort study. Setting: Tertiary care center. Patients: Fifteen women with active Six were premenopausal nine postmenopausal. All had evidence of thyrotoxicosis as indicated by a raised total serum thyroxine, suppressed thyroid-stimulating hormone, an elevated technetium-99m pertechnetate thyroid scan. A control group 15 healthy volunteers matched age, sex,...
Objective To examine prognostic factors and outcomes after hip fracture in men aged 60 years older. Design setting Cohort study of all presenting to St George Hospital (a 650-bed tertiary care centre) with fractures 1995, recruited retrospectively from medical records evaluated prospectively at six 12 months fracture. Patients 51 or more (and, for comparison, age-matched women) who presented not caused by high impact injuries local bone disease. Main outcome measures Prognostic (such as...
OBJECTIVE--To determine whether two adults with stress fractures receiving low weekly doses of methotrexate had osteopathy. CASE REPORTS--Two adult patients developed features consistent osteopathy while methotrexate. METHODS--Iliac crest biopsy samples were taken and bone histomorphometry carried out. RESULTS--Symptoms resolved when the was discontinued. Bone histology showed changes osteoblast inhibition by CONCLUSIONS--When given in for prolonged periods, may have adverse effects on bone,...
Abstract Purpose: To determine the effect of curcumin on plasma cells and osteoclasts in patients with MGUS. Experimental Design: Twenty-six MGUS were recruited into study administered 4 grams/day oral curcumin. Blood urine samples collected at specified visits after initiating therapy. Full blood count, B2 microglobulin, serum paraprotein, immunoglobulin electrophoresis (IEPG EPG) determined for all each visit. Serum calcium, 25 hydroxyvitamin D3, bone-specific alkaline phosphatase baseline...
BackgroundAge-related hip fractures are associated with poor functional outcomes, resulting in substantial personal and societal burden. There is a need to better identify reversible etiologic predictors of suboptimal recovery this group.
Endoscopic transsphenoidal surgery for pituitary adenomas has been introduced as an alternative to microsurgery. This is the first Australian study evaluate a single surgeon's experience by comparing our results with other series and attempting identify learning curve. Retrospective analysis was carried out on 79 consecutively treated patients fully endoscopic neurosurgeon over period spanning from July 1998 September 2010 at St George Public Private hospitals. The mean age time of 56.7...