A5055572711- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Metabolism, Diabetes, and Cancer
- Ubiquitin and proteasome pathways
- Free Radicals and Antioxidants
- Mitochondrial Function and Pathology
- Sirtuins and Resveratrol in Medicine
- Biochemical effects in animals
Fudan University
2019-2020
Zhongshan Hospital
2020
State Key Laboratory of Genetic Engineering
2019
The folate-coupled metabolic enzyme MTHFD2 (the mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase) confers redox homeostasis and drives cancer cell proliferation migration. Here, we show that is hyperacetylated lysine 88 the critical acetylated site. SIRT3, major deacetylase in mitochondria, responsible for deacetylation. Interestingly, chemotherapeutic agent cisplatin inhibits expression of SIRT3 to induce acetylation colorectal cells. Cisplatin-induced K88 sufficient...
Phosphoglycerate dehydrogenase (PHGDH) is the first and rate-limiting enzyme in serine synthesis pathway, which significantly upregulated many cancers, especially breast cancer. However, posttranslational mechanism of upregulating PHGDH cancer unknown. In this study, we found that RNF5, an E3 ubiquitin ligase, was essential for degradation protein. degraded by RNF5 to prevent proliferation cells. Acetylated at K58 able disrupt interaction RNF5-PHGDH promote cell proliferation. Tip60 SIRT2...