A5046934069- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Obsessive-Compulsive Spectrum Disorders
- Pain Management and Treatment
- Cerebrospinal fluid and hydrocephalus
- Neonatal and fetal brain pathology
- Epilepsy research and treatment
- Network Time Synchronization Technologies
- Heart Rate Variability and Autonomic Control
- Vagus Nerve Stimulation Research
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Syncope and Autonomic Disorders
- Neuroscience and Neural Engineering
University of Oxford
2017-2025
Nuffield Orthopaedic Centre
2025
John Radcliffe Hospital
2022-2024
University Hospital and Clinics
2024
Johannes Gutenberg University Mainz
2024
University Medical Center of the Johannes Gutenberg University Mainz
2024
University Medical Center
2024
Wellcome Centre for Integrative Neuroimaging
2017-2018
Key points The ability to learn new motor skills is supported by plasticity in the structural and functional organisation of primary cortex human brain. Changes inhibitory signalling GABA are thought be crucial inducing plasticity. This study used magnetic resonance spectroscopy (MRS) quantify concentration during a period learning, as well movement at rest. We report evidence for reduction MRS‐measured specific learning. Further, early learning task was strongly correlated with magnitude...
Understanding both the organization of human cortex and its relation to performance distinct functions is fundamental in neuroscience. The primary sensory cortices display topographic organization, whereby receptive fields follow a characteristic pattern, from tonotopy retinotopy somatotopy [1]. GABAergic signaling vital maintenance cortical [2]; however, it unclear how this fine-grain inhibition relates measurable patterns perception [3, 4]. Based on perceptual changes following...
Research question We previously reported that Deep Brain Stimulation (DBS) of motor thalamus (MT), in a patient with post-stroke tremor, relieved breathlessness associated chronic obstructive pulmonary disease. This raised the whether MT DBS mitigates ascending dyspnoea signal. therefore sought to conduct fully powered cohort study experimentally induced air hunger (AH), an uncomfortable urge breathe patients ON and OFF. Methods 16 (3 females) ventral intermediate nucleus (VIM) as treatment...
Abstract Deep brain stimulation of the pedunculopontine nucleus is a promising surgical procedure for treatment Parkinsonian gait and balance dysfunction. It has, however, produced mixed clinical results that are poorly understood. We used tractography with aim to rationalise this heterogeneity. A cohort eight patients postural instability disturbance (Parkinson’s disease subtype) underwent pre-operative structural diffusion MRI, then progressed deep targeting nucleus. Pre-operative...
The ability to learn novel motor skills is both a central part of our daily lives and can provide model for rehabilitation after stroke. However, there are still fundamental gaps in understanding the physiological mechanisms that underpin human plasticity. acquisition new dependent on changes local circuitry within primary cortex (M1). This reorganisation has been hypothesised be facilitated by decrease inhibition via modulation neurotransmitter GABA, but this link not conclusively...
The dorsal anterior cingulate cortex (dACC) is a key node in the human salience network. It has been ascribed motor, pain-processing and affective functions. However, dynamics of information flow this complex region how it responds to inputs remain unclear are difficult study using non-invasive electrophysiology. area targeted by neurosurgery treat neuropathic pain. During deep brain stimulation surgery, we recorded local field potentials from humans during decision-making task requiring...
Abstract Surgical neuromodulation through implantable devices allows for stimulation delivery to subcortical regions, crucial symptom control in many debilitating neurological conditions. Novel closed-loop algorithms deliver therapy tailor-made endogenous physiological activity, however rely on precise sensing of signals such as oscillations. The frequency intrinsic activity can vary depending target nucleus, while factors regional anatomy may also contribute variability signals. While...
Surgical neuromodulation through implantable devices allows for stimulation delivery to subcortical regions, crucial symptom control in many debilitating neurological conditions. Novel closed-loop algorithms deliver therapy tailor-made endogenous physiological activity, however rely on precise sensing of signals such as oscillations. The frequency intrinsic activity can vary depending target nucleus, while factors regional anatomy may also contribute variability signals. While artefact...