A5026088114- Immunotherapy and Immune Responses
- Thyroid Cancer Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- T-cell and B-cell Immunology
- Histone Deacetylase Inhibitors Research
- Systemic Lupus Erythematosus Research
- Salivary Gland Tumors Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- GDF15 and Related Biomarkers
- Lung Cancer Treatments and Mutations
- Click Chemistry and Applications
- vaccines and immunoinformatics approaches
- Head and Neck Anomalies
- Influenza Virus Research Studies
- Nutrition and Health in Aging
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- Antimicrobial Peptides and Activities
- Biochemical and Molecular Research
- Biosimilars and Bioanalytical Methods
- Lung Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Pharmaceutical studies and practices
- Rheumatoid Arthritis Research and Therapies
University of Florence
2023-2025
University of Siena
2010-2021
Context: Fine-needle aspiration cytology (FNAC) is the gold standard for differential diagnosis of thyroid nodules but has limitation inadequate sampling or indeterminate lesions. Objective: We aimed to verify whether search cancer-associated protooncogene mutations in cytological samples may improve diagnostic accuracy FNAC. Study Design: One hundred seventy-four consecutive patients undergoing surgery were submitted FNAC (on 235 nodules) that was used and molecular analysis BRAF, RAS, RET,...
Background:The association of thyroid cancer and autoimmune thyroiditis (AIT) has been widely addressed, with conflicting results in surgical cytological series, likely affected by selection bias.
The use of adalimumab biosimilars has become increasingly common in clinical practice, reflecting their growing acceptance and efficacy as therapeutic alternatives to reference biologics. However, studies investigating the molecular interactions between anti-adalimumab antibodies (AAA) elicited patients different remain limited. This study aims characterize kinetic purified AAA from pediatric with Juvenile Idiopathic Arthritis three formulations: originator Humira®, GP2017 (Hyrimoz®) SB5...
The use of adalimumab biosimilars has become increasingly common in clinical practice, reflecting their growing acceptance and efficacy as therapeutic alternatives to reference biologics. However, studies investigating the molecular interactions between anti-adalimumab antibodies (AAA) elicited patients different remain limited. This study aims characterize kinetic purified AAA from pediatric with Juvenile Idiopathic Arthritis three formulations: originator Humira®, GP2017 (Hyrimoz®) SB5...
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed a great concern in human population. To fight coronavirus emergence, we have dissected the conserved amino acid region of internal fusion peptide S2 subunit Spike glycoprotein SARS-CoV-2 to design new inhibitory peptides. Among 11 overlapping peptides (9-23-mer), PN19, 19-mer peptide, exhibited powerful activity against different clinical isolate variants absence cytotoxicity. The PN19 was found be dependent on...
Protein therapeutics are extensively used in the treatment of autoimmune diseases, but a subset patients appears to be refractory these treatments, mainly due development an immune response drug. A better understanding mechanism underlying therapeutic drug’s failure becomes fundamental for new and more effective treatments. Unfortunately, there few cases where exact mechanisms through which drugs bypass immunological tolerance provoke immunogenicity have been studied. In this context,...
Introduction The management of patients with indeterminate thyroid nodules, which account for 10–25% fine needle aspiration biopsies (FNABs), is still very challenging. Aim To verify the utility seven-gene panel in combination ultrasound features clinical nodules. Results study group included 188 divided into TIR3A (56.4%) and TIR3B (43.6%). A significant correlation between US categories both cytological molecular results was observed. In detail, cytology more frequent EU-TIRADS 4 5 nodules...
Monitoring of therapeutic antibody adalimumab (ADL) and anti-adalimumab antibodies (AAA) in autoimmune diseases' patient sera has achieved increased attention since several studies showed a correlation between AAA levels treatment failure. We evaluated new surface plasmon resonance (SPR)-based biosensor to monitor both ADL patients' sera, evaluating their agreement with commercial ELISA. Sera from ADL-treated patients (n = 47) controls 13) were included this study. Quantitative analysis...