Aim: Polycystic ovary syndrome (PCOS) is an increasingly recognized endocrine disorder. The pathogenesis not fully known. still difficult to diagnose correctly, despite simple diagnostic criteria. aim of the study review current knowledge about PCOS and treatment options for patients with disease. To explore this topic, publications were reviewed conclusions drawn from them. incidence hyperandrogenism in a patient may be as high 60–80%. Increased androgen levels affect ovulation...

Oxidative stress plays an important role in IBD because chronic intestinal inflammation is associated with the overproduction of reactive oxygen species (ROS) leading to oxidative stress, which has been implicated IBD. Many lines evidence suggest that imbalance between ROS and antioxidant activity generates as result either or a decrease activity. Our study was evaluate influence antioxidants on course disease treatment patients. results show increase LOOH levels positively correlates MDA...

Complex interaction of genetic defects with environmental factors seems to play a substantial role in the pathogenesis inflammatory bowel disease (IBD). Accumulating data implicate potential disturbed tryptophan metabolism IBD. Kynurenic acid (KYNA), derivative (TRP) along kynurenine (KYN) pathway, displays cytoprotective and immunomodulating properties, whereas 3-OH-KYN is cytotoxic compound, generating free radicals.

The BIRC5 gene encodes a survivin protein belonging to class III of inhibitors apoptosis, IAP. This serves dual role. First, it regulates cell death, and second, is an important regulator mitosis progression, although its physiological regulatory function has not been fully understood. Many studies have shown confirmed that practically absent in mature tissues nature, while overexpression reported many cancerous tissues. There little information about the significance expression normal adult...

Abstract Background Acute myeloid leukemia (AML) is a heterogenic lethal disorder characterized by the accumulation of abnormal progenitor cells in bone marrow which results hematopoietic failure. Despite various efforts detection and treatment, many patients with AML die this cancer. That why it important to develop novel therapeutic options, employing strategic target genes involved apoptosis tumor progression. Methods The aim study was evaluate PARP1, PARP2, PARP3, TRPM2 gene expression...

Gastric cancer (GC) is one of the most common cancers in world. It a multi-factorial disease influenced by both genetic and environmental factors such as diet, obesity, radiation exposure, infectious agents. Viral infections usually lead to chronic inflammation, which can initiate development cancers. To date, only few studies have been published about Epstein-Barr virus (EBV) human papillomavirus (HPV) context GC. In particular, research on among people under 45 years age, including impacts...

Inflammatory bowel disease (IBD) mainly includes ulcerative colitis (UC) and Crohn's (CD). These diseases are classified as chronic recurrent inflammatory affecting the digestive tract. An energy deficiency in intestinal cells is believed to be associated with IBD pathology. Our study investigated bioenergetic functionality of mitochondria using plasma patients CD UC by determining concentration intermediates tricarboxylic acid cycle (TCA), such acetyl coenzyme A, succinate, fumarate,...

Schizophrenia is a severe and chronic mental illness usually diagnosed in adolescents young adults. Many studies indicate that oxidative stress causes membrane dysfunction cell damage, which implicated the pathophysiology of schizophrenia. The purpose our study was to evaluate markers (the main primary products lipid peroxidation, hydroperoxides (LOOH), end malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), Ferric Reducing Ability Plasma (FRAP)) plasma patients with first...

Cel pracy Celem było 1) porównanie poziomu ekspresji genów apoptozy BAX, BCL2, BIRC6, CASP3, CASP9 u pacjentów ze schizofrenią i w grupie kontrolnej oraz 2) określenie powiązań pomiędzy poziomem a parametrami morfologicznymi krwi obwodowej nasileniem objawów psychopatologicznych. Metoda Do badania włączono 21 z rozpoznaniem schizofrenii wg ICD-10 26 zdrowych osób. Oceniano ekspresję limfocytach obwodowej, parametry laboratoryjne nasilenie psychopatologicznych za pomocą skali PANSS. Wyniki...

Determination of the exact time death a human being or animal is extremely important for investigations conducted by law enforcement agencies. The development single model tests and analysis site incident would be breakthrough forensic veterinary medicine in estimating death. Microorganisms play key role putrefaction process. Each stage decomposition characterized colonization tissues different microbial taxa. objective study was to determine suitability microbiological establishing death,...

Background and objectives: Inflammatory bowel disease (IBD) mainly includes Crohn's (CD) ulcerative colitis (UC). Both conditions are associated with an exacerbated intestinal immune response to harmless stimuli, leading upregulation of pro-inflammatory mediators. Materials Methods: The subjects the study were 55 patients IBD. control group consisted 35 healthy subjects. researched material peripheral blood lymphocytes collected from Expression genes BAX, BCL2, CASP3 CASP9 was assessed at...

Introduction . Inflammatory bowel disease (IBD) is a complicated, multifunctional disorder characterized by chronic, recurring inflammation of the digestive tract. The two main types IBD are ulcerative colitis (UC) and Crohn’s (CD). aim study was to determine single nucleotide polymorphism in fragments genes CARD15/NOD2 DLG5 patients from Lublin Voivodeship. Patients Methods carried out (Poland) 2016. 27 individuals participated research. research group comprised 9 with diagnosis colitis,...

Inflammatory bowel disease (IBD), which mainly includes ulcerative colitis (UC) and Crohn’s (Lesniowski-Crohn’s, ChL-C, CD), is a chronic recurrent inflammatory condition of the gastrointestinal tract with multifactorial causes. Both types IBD are characterized by inflammation periods remission exacerbation. An increasing number studies have recently shown that plays an important role in carcinogenesis colorectal cancer (CRC), generating suitable microenvironments for formation progression...

The multifunctional characteristics of Phallus impudicus extract encourage to conduct research for its potential use in medical applications. Well, science is constantly seeking new evidence the biological activity extracts natural origin. Drugs origin should not cause any side effects on physiological functions human body; however, this always successful. In study, we used vitro approach evaluate toxicity alcohol spermatogenic cells. We show, first time, cytotoxic properties treatment...

There is growing evidence that intestinal proteases have a role in the pathogenesis of gastrointestinal inflammatory diseases. Inflammatory bowel disease (IBD), which includes Crohn's (CD) and ulcerative colitis (UC), has an additional source represented by infiltrated activated cells. The aim our study was to determine proteolytic system activity patients with CD UC. We limited number tested determining active acidic, neutral alkaline pH.The included 40 IBD - 20 UC patients. control group...

The link between the kynurenine pathway and immunomodulatory molecules—fractalkine soluble intercellular adhesion molecule-1 (sICAM-1)—in anorexia nervosa (AN) remains unknown. Fractalkine, sICAM-1, tryptophan (TRP), (KYN), neuroprotective kynurenic acid (KYNA), neurotoxic 3-OH-kynurenine (3-OH-KYN), expression of mRNA for aminotransferases (KAT1-3) were studied in 20 female patients with restrictive AN (mostly drug-free, all during first episode disease) 24 controls. In AN, serum...

Surgical treatments and chemotherapy are the most commonly used methods of colorectal cancer treatment (CRC), unfortunately, these therapies have many side effects. Moreover, despite advances in primary adjuvant treatments, survival time CRC patients is still unsatisfactory. Treatment options for with continue to advance recent research has shown that sensitive plant-derived substances. The use natural compounds contained herbal extracts colon or as adjunctive therapy gives a wide range...

Abstract Background: Acute myeloid leukemia (AML) is a heterogenic lethal disorder characterized by the accumulation of abnormal progenitor cells in bone marrow which results hematopoietic failure. Despite various efforts detection and treatment, many patients with AML die this cancer. That why it important to develop novel therapeutic options, employing strategic target genes involved apoptosis tumor progression. Methods: The aim study was evaluate PARP1, PARP2, PARP3, TRPM2 gene expression...

The effects of physical factors such as radiation (electromagnetic, microwave, infrared, laser, UVC, and X-ray) high temperature, well chemical (controlled atmosphere) on the level global DNA cytosine methylation in C. albicans ATCC 10231 cells were investigated. Prolonged exposure to each type significantly increased level. In addition, with incubation temperature. An increase percentage methylated was also noted cultured an atmosphere reduced O2. contrast, containing more than 3% CO2...

The carriage of methicillin-resistant S. aureus (MRSA) strains may determine the subsequent occurrence infection, which mainly affects patients after surgeries. Therefore, its eradication with use antibiotics or antiseptics is a crucial method preventing staphylococcal self-infections. observed increase in bacterial resistance to known antibacterial substances poses huge challenge scientists. aim this study was analyze interaction selected commercial (Braunol, CITROclorex 2%, Microdacyn 60...

Toxoplasma gondii (T. gondii) is a protozoan parasitizing all warm-blooded mammals, including humans. The main source of infection contact with the feces infected animals, particularly housecats, – definitive hosts, in which T. completes its life cycle. Alternative sources are and consumption contaminated meat (particularly pork), transmission from mother to fetus, by oocytes present soil or polluted water. geographically ubiquitous; level seroprevalence estimated range about 3% South Korea...