A5028784623- Pituitary Gland Disorders and Treatments
- Adrenal Hormones and Disorders
- Adrenal and Paraganglionic Tumors
- Cerebrospinal fluid and hydrocephalus
- Retinoids in leukemia and cellular processes
- Cardiomyopathy and Myosin Studies
- Heart Rate Variability and Autonomic Control
- Estrogen and related hormone effects
- Cardiovascular Syncope and Autonomic Disorders
- Neurological and metabolic disorders
- Growth Hormone and Insulin-like Growth Factors
- Hormonal Regulation and Hypertension
- Pancreatitis Pathology and Treatment
- Diabetes Management and Research
- Congenital Anomalies and Fetal Surgery
- Trypanosoma species research and implications
- Cardiovascular Function and Risk Factors
- Abdominal Trauma and Injuries
- Heme Oxygenase-1 and Carbon Monoxide
- Heart Failure Treatment and Management
- Head and Neck Surgical Oncology
Brigham and Women's Hospital
2024
Harvard University
2024
Erasmus MC
2021
Universidade Federal de São Paulo
2007-2020
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2018
Union des Industries Ferroviaires Européennes
2007
In Cushing syndrome (CS), prolonged exposure to high cortisol levels results in a wide range of devastating effects causing multisystem morbidity. Despite the efficacy treatment leading disease remission and clinical improvement, hypercortisolism-induced complications may persist. Since glucocorticoids use epigenetic machinery as mechanism action modulate gene expression, persistence some comorbidities be mediated by long-lasting changes. Additionally, influence microRNA which is an...
The genetic profile of prolactinomas remains poorly understood. Our objective is to identify somatic alterations associated with and report the identification an activating ESR1 mutation (ESR1Y537S) in aggressive prolactinoma.
Abstract Disclosure: T. Paes: None. J.B. Mebarak: J. C. Magnotto: G. A. Stamatiades: Y. Kuang: Paweletz: E.R. Laws: R.S. Carroll: R. Jeselsohn: D. Mohan: Marcondes Lerario: W. L. Bi: Reardon: M. Meredith: U.B. Kaiser: Abreu: Introduction: Prolactinomas are benign tumors typically treated with dopamine agonists; few progress on medical therapy, through unclear molecular mechanisms. Although the SF3B1 mutation has been identified in one study as a driver of aggressive prolactinomas, most cases...
Hepatic infarction is characterized by parenchyma ischemic necrosis involving at least two acinis. It extremely uncommon due to the arterial and portal venous blood supply. We report a case of patient not know have diabetes who developed massive areas infarcts liver after episode acutely decompensated.A 67 year-old hypertensive female has been presenting, for last 10 days, polydipsia, high urinary volume, visual gait impairment, nausea vomiting was admitted emergency room (ER). During...
Acute heart failure - Epidemiology, prognosis, outcome 1395 quently in hemodynamic profile C (41.4% vs 29.9%, P=0.028) and had lower rate (74.3±20.7bpmvs 86.5±25.5bpm,P<0.001), arterial pressure (mean sBP 92.7±62.8vs 103.2 mmHg, mean dBP 62.8±14.8 vs. 67.2±16.2mmHg, P<0.001) higher BNP levels (2050±1572pg/mL 1330±1274pg/mL, P=0.034); echocardiography indicated that Chagas patients LV ejection fraction (26.6±8.5% 30.8±11.5%,P<0.001), larger diastolic diameter (68.9±8.6mmvs...
Abstract Context: The lack of efficacy octreotide in the medical treatment Cushing’s disease (CD) may result from suppressive effects hypercortisolism on somatostatin receptor subtype 2 (SST2) expression by corticotroph adenomas. We previously demonstrated that SST2 mRNA levels tumor cells patients preoperatively treated with cortisol-lowering therapy are significantly higher compared to those uncontrolled CD at time surgery. It be hypothesized control cortisol production induced...