A5063119830- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Sulfur-Based Synthesis Techniques
- Pesticide and Herbicide Environmental Studies
- Synthesis and biological activity
- Phenothiazines and Benzothiazines Synthesis and Activities
- Andrographolide Research and Applications
- Weed Control and Herbicide Applications
- Synthesis and Biological Evaluation
- Catalytic C–H Functionalization Methods
- Catalytic Alkyne Reactions
- Psidium guajava Extracts and Applications
- Berberine and alkaloids research
- Organic and Inorganic Chemical Reactions
- Fungal Plant Pathogen Control
- Drug Transport and Resistance Mechanisms
- Natural Antidiabetic Agents Studies
- Phytochemistry and Biological Activities
- Allelopathy and phytotoxic interactions
- Click Chemistry and Applications
- Catalytic Cross-Coupling Reactions
- Peptidase Inhibition and Analysis
- Cyclopropane Reaction Mechanisms
- Cancer therapeutics and mechanisms
- Bioactive Natural Diterpenoids Research
Minzu University of China
2025
Central Institute of Medicinal and Aromatic Plants
2014-2021
Central China Normal University
2017-2018
Art Research Centre of the Slovak Academy of Sciences
2015
The issue of weed resistance to acetohydroxyacid synthase (EC 2.2.1.6, AHAS) inhibitors has become one the largest obstacles for application this class herbicides. In a continuing effort discover novel AHAS overcome resistance, series pyrimidine–biphenyl hybrids (4aa–bb and 5aa–ah) were designed synthesized via scaffold hopping strategy. Among these derivatives, compounds 4aa (Ki = 0.09 μM) 4bb 0.02 displayed higher inhibitory activities against Arabidopsis thaliana than those controls...
A novel and effective method for the synthesis of chiral C1-phosphinoylated 1H-isochromenes has been developed. The reaction proceeds via a tandem asymmetric addition/cyclization under catalytic system Pd(OAc)2, Josiphos-based ligand L9, ZnCl2 in MeCN at 70 °C. This demonstrates broad substrate scope (27 examples), delivering excellent yields (up to 92%) enantioselectivities 95%).
In the search for new antiresistance acetohydroxyacid synthase (AHAS, EC 2.2.1.6) inhibitors to combat weed resistance associated with AHAS mutations, a series of 2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)oxy]-6-(substituted phenoxy)benzoic acids 11-38 were designed and synthesized via strategy conformational flexibility analysis. Compounds 21, 22, 26, 33, 36, 38 high potency against both wild-type AtAHAS its P197L mutant identified as promising candidates low factors (RF, defined ratio between...
Ceric ammonium nitrate facilitates andrographolide-3,19-<italic>O</italic>-acetal formation with alcohols. Anticancer active derivatives showed good docking scores in <italic>in silico</italic>.
Abstract Biologically important three different pharmacophores, forskolin, indole and 1,2,3‐triazoles are coupled to obtain a hybrid molecule. Here, we described the synthesis of novel series forskolin‐indole‐triazole conjugates 5a‐5l by using Cu(I) catalyzed 1,3‐dipolar cycloaddition reaction. Furthermore, biological significance synthesized molecules was assessed in silico vitro modes. All compounds were evaluated for anticancer activity against PC‐3, MCF‐7, MDA‐MB‐231, COLO‐205, HeLa,...
Synthesis, <italic>in vitro</italic> antiproliferative and α-glucosidase inhibitory activities of novel 3-(allyloxy)-propylidene acetals some natural terpenoids.
Objective: Isolation of compounds from Euphorbia fusiformis rhizomes and evaluation extracts each isolates for its antioxidant antifungal activities. Results: Five were isolated including Euphol 1, b-Sitosterol 2, Caudicifolin 3, Scoparone 4 Scopoletin 5. The occurrence the 5 in herb reported here first time. ethyl acetate extract showed significant activity (IC 50 = 2.781 �g/ml) yielded compound 3 moderate 3.25 using DPPH method. better against Aspergillus niger Candida albicans....