A5029612834- Gene Regulatory Network Analysis
- Bacterial Genetics and Biotechnology
- RNA and protein synthesis mechanisms
- Bacteriophages and microbial interactions
- Microstructure and mechanical properties
- Protein Structure and Dynamics
- Genomics and Chromatin Dynamics
- Force Microscopy Techniques and Applications
- Micro and Nano Robotics
- Evolution and Genetic Dynamics
- Lipid Membrane Structure and Behavior
- DNA and Nucleic Acid Chemistry
- Advanced Thermodynamics and Statistical Mechanics
- Microtubule and mitosis dynamics
- Ion channel regulation and function
- Metal and Thin Film Mechanics
- Nanopore and Nanochannel Transport Studies
- Receptor Mechanisms and Signaling
- Microbial Metabolic Engineering and Bioproduction
- Erythrocyte Function and Pathophysiology
- Photosynthetic Processes and Mechanisms
- Genomics and Phylogenetic Studies
- Cellular Mechanics and Interactions
- Quasicrystal Structures and Properties
- Genetics, Bioinformatics, and Biomedical Research
California Institute of Technology
2016-2025
Astronomy and Space
2025
Pasadena City College
2022-2024
Chan Zuckerberg Initiative (United States)
2020-2023
Chan Zuckerberg Biohub San Francisco
2022
Weizmann Institute of Science
2020
University of California, Berkeley
2020
Massachusetts Institute of Technology
2018
Centre National de la Recherche Scientifique
2001-2015
Institute of Molecular Biology and Biophysics
2015
Significance The composition of the biosphere is a fundamental question in biology, yet global quantitative account biomass each taxon still lacking. We assemble census all kingdoms life. This analysis provides holistic view and allows us to observe broad patterns over taxonomic categories, geographic locations, trophic modes.
Abstract We develop a method which permits the analysis of problems requiring simultaneous resolution continuum and atomistic length scales-and associated deformation processes-in unified manner. A finite element methodology furnishes statement problem interest provides requisite multiple-scale capability by adaptively refining mesh near lattice defects other highly energetic regions. The differs from conventional analyses in that interatomic interactions are incorporated into model through...
The COVID-19 pandemic is a harsh reminder of the fact that, whether in single human host or wave infection across continents, viral dynamics often story about numbers. In this article we provide one-stop, curated graphical source for key numbers (based mostly on peer-reviewed literature) SARS-CoV-2 virus that responsible pandemic. discussion framed around two broad themes: i) biology itself; ii) characteristics host.
Quantitatively describing the time course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection within an infected individual is important for understanding current global pandemic and possible ways to combat it. Here we integrate best knowledge about typical viral load SARS-CoV-2 in bodily fluids host tissues estimate total number mass virions person. We that each person carries 109 1011 during peak infection, with a range 1 μg 100 μg, which curiously implies all...
Variability in gene expression among genetically identical cells has emerged as a central preoccupation the study of regulation; however, divide exists between predictions molecular models prokaryotic transcriptional regulation and genome-wide experimental studies suggesting that this variability is indifferent to underlying regulatory architecture. We constructed set promoters Escherichia coli which promoter strength, transcription factor binding copy numbers are systematically varied, used...
Viruses may very well be the most abundant biological entities on planet. Yet neither metagenomic studies nor classical phage isolation techniques have shed much light identity of hosts viruses. We used a microfluidic digital polymerase chain reaction (PCR) approach to physically link single bacterial cells harvested from natural environment with viral marker gene. When we implemented this technique microbial community residing in termite hindgut, found genus-wide infection patterns...
The modeling of processes involving multiple length scales is an area pressing concern, especially in problems such as nanoidentation and crack tip dislocation activity. In these cases, there more than one characteristic dimension with the nanometer scale arising due to presence extended defects dislocations a second at least 2 orders magnitude larger set by indenter or itself. To properly model processes, both must be treated explicitly, which normally beyond scope conventional atomistic...
Microscopic models of the interaction between grain boundaries (GBs) and both dislocations cracks are importance in understanding role microstructure altering mechanical properties a material. A recently developed mixed atomistic continuum method is extended to examine GBs, cracks. These calculations elucidate plausible microscopic mechanisms for these defect interactions allow quantitative evaluation critical parameters such as stress nucleate dislocation at step on GB force needed induce migration.
A new generation of single-molecule experiments has opened up the possibility reexamining many fundamental processes biochemistry and molecular biology from a unique quantitative perspective. One technique producing host intriguing results is use optical tweezers to measure mechanical forces exerted by motors during key such as transcription DNA or packing viral genome into its capsid. The objective current article respond measurements on viruses theory elasticity simple model charge...