A5042147723- Elder Abuse and Neglect
- Intimate Partner and Family Violence
- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Grief, Bereavement, and Mental Health
- Ion Channels and Receptors
- Receptor Mechanisms and Signaling
- Interdisciplinary Research and Collaboration
- Career Development and Diversity
- Sodium Intake and Health
- Nitric Oxide and Endothelin Effects
- Engineering Education and Curriculum Development
- Engineering Education and Pedagogy
- Renal and Vascular Pathologies
- Discourse Analysis in Language Studies
- Vascular anomalies and interventions
- Healthcare Decision-Making and Restraints
- Magnesium in Health and Disease
- Sepsis Diagnosis and Treatment
- Cardiovascular and exercise physiology
- Problem and Project Based Learning
- Hemodynamic Monitoring and Therapy
- Disaster Management and Resilience
- Diet and metabolism studies
Presbyterian Hospital
2022-2024
New York Hospital Queens
2022-2024
NewYork–Presbyterian Hospital
2022-2024
Cornell University
2022-2024
Wellesley Centers for Women
2024
Wellesley College
2024
Massachusetts Institute of Technology
2023-2024
University of Central Florida
2024
Oregon Health & Science University
2023
Oregon National Primate Research Center
2023
The (pro)renin receptor (PRR), which binds both renin and prorenin, is a newly discovered component of the renin–angiotensin system that highly expressed in central nervous system. significance brain PRRs mediating local angiotensin II formation regulating blood pressure remains unclear. current study was performed to test hypothesis PRR-mediated, nonproteolytic activation prorenin main source brain. Thus, PRR knockout expected prevent development deoxycorticosterone acetate-salt–induced...
We previously reported that binding of prorenin to the (pro)renin receptor (PRR) plays a major role in brain angiotensin II formation and development deoxycorticosterone acetate (DOCA)-salt hypertension. Here, we designed developed an antagonistic peptide, PRO20, block PRR. Fluorescently labeled PRO20 bound both mouse human tissues with dissociation constants 4.4 1.8 nmol/L, respectively. This was blocked by coincubation diminished brains neuron-specific PRR-knockout mice, indicating...
Problem-based invention education engages students in complex processes of solving ill-defined problems with the support teachers who act as facilitators learning process. Guided by interactional ethnographic epistemology (Green et al., 2012), we examine and what ways supported a high school team their teacher working to invent solution real-world problem identified community. Our primary dataset included video recordings historian’s notebook collected InvenTeam historian during project....
Abstract Background An emergency department (ED) visit provides a unique opportunity to identify elder abuse and initiate intervention, but providers rarely do. To address this, we developed the Vulnerable Elder Protection Team (VEPT), an ED‐based interdisciplinary consultation service. We describe our initial experience in first two years after program launch. Methods launched VEPT large, urban, academic ED/hospital. From 4/3/17 4/2/19, tracked activations, including patient...
Holes within the internal elastic lamina (IEL) of blood vessels are sites fenestration allowing for passage diffusible vasoactive substances and interface endothelial cell membrane projections with underlying vascular smooth muscle. Endothelial dynamic Ca2+ events leading to endothelium dependent hyperpolarization (EDH)-mediated relaxations activity these increase as vessel diameter decreases. We tested hypothesis that IEL is greater in distal vs. proximal arteries skeletal muscle, unlike...
Introduction: Hypoxia-induced dilation of cerebral arteries orchestrated by Ca2+-permeable transient receptor potential ankyrin 1 (TRPA1) cation channels on endothelial cells is neuroprotective during ischemic stroke, but it unknown if the channel has a similar impact hemorrhagic stroke. TRPA1 are endogenously activated lipid peroxide metabolites generated reactive oxygen species (ROS). Uncontrolled hypertension, primary risk factor for development associated with increased ROS production...
Background The National Early Warning Score (NEWS) calculated from physiological observations provides a simple away to identify and respond the deteriorating patient. There is increasing interest in application of NEWS facilitate referrals community. Aim To establish whether elevated are associated with adverse outcomes at 5 30 days when obtained community setting time transfer an acute setting. Design & A retrospective service evaluation was undertaken using database emergency...
Elder mistreatment (EM) is a complex problem, with response and prevention requiring contributions from professionals many disciplines. Community-based multi-disciplinary teams (MDTs) that conduct meetings to discuss challenging cases coordinate services are common strategy ensure effective collaboration. Though they play an important role in EM identification, intervention, prevention, hospitals hospital-based healthcare have been particularly difficult engage MDTs. Two different...
Latinas, along with many other minoritized groups, are underrepresented as inventors in the United States. Despite accounting for over 9% of population, <1% U.S. patent holders Latina. In an effort to increase diversity among and holders, a number K-12 programs have been created provide opportunities students participate iterative recursive processes inventing. One example is emerging field invention education. Invention education educational approach which teaches how identify solve...
Despite advances in antihypertensive therapeutics, at least 15–20% of hypertensive patients have resistant hypertension through mechanisms that remain poorly understood. In this study, we provide a new mechanism for the regulation blood pressure (BP) central nervous system (CNS) by (pro)renin receptor (PRR), recently identified component renin-angiotensin mediates ANG II formation CNS. Although PRR also II-independent signaling, importance these pathways BP is unknown. Here, developed unique...
Introduction Although many programmes have been developed to address elder mistreatment, high-quality, rigorous evaluations assess their impact are lacking. This is partly due challenges in conducting programme evaluation for such a complex phenomenon. We describe here the development of protocol mitigate these and rigorously evaluate first-of-its-kind emergency department/hospital-based mistreatment intervention, Vulnerable Elder Protection Team (VEPT). Methods analysis used multistep...
Interdisciplinary Emergency Department/hospital-based teams represent a promising care model to improve identification of and intervention for elder mistreatment. Two institutions, Weill Cornell Medicine/NewYork-Presbyterian Hospital the University Colorado Anschutz Medical Campus have launched such programs are exploring multiple strategies effective dissemination. These include: (1) program evaluation research, (2) framing as new geriatric care, (3) understanding existing incentives health...
Elder mistreatment, including elder abuse and neglect, is a difficult diagnosis to make manage for most providers. To address this, two consultation teams were developed patients in the hospital emergency department settings. As these have developed, providers involved obtained specialized training experience that we believe contributes new field of geriatrics, corollary well-established child pediatrics. Providers working this require scope practice includes forensic evaluation, evaluation...
Elder mistreatment is common, serious, and under-recognized, with Emergency Department hospital clinical encounters offering a potential but currently unrealized opportunity to identify help older adults experiencing mistreatment. Interdisciplinary emergency department hospital-based response teams represent promising care model address this. This manuscript describes two such introduces special issue dedicated this work.
Invention Education (IvE), a form of problem-based learning, presents new challenges for educational assessments in public schooling because traditional were designed to evaluate learning singular disciplines. This study explores the and possibilities assessing knowledge capabilities acquired through students’ engagement with multiple disciplines IvE. Guided by constructivist sociocultural theories, as well an understanding IvE principles practices derived from literature on IvE, we examine...
Dialogue is central to the collaborative processes of inquiry-based approaches. In this methodological article on Interactional Ethnography (IE), we outline guiding principles IE as a logic inquiry for studying talk and actions learners their mentors in learning. Through telling case facilitation high school invention education (IvE), illustrate major steps analytic that an research team undertakes collect, archive, analyze records classroom We share how enters ethnographic space...
We reported that brain (pro)renin receptor (PRR) expression is elevated in deoxycorticosterone acetate (DOCA)‐salt hypertension; however, the underlining mechanism remains unknown. To test our hypothesis epigenetic involved regulation of PRR DOCA‐salt hypertension, C57Bl/6J mice were implanted with SHAM or DOCA pellet and supplied saline for 3 weeks. Histone modifications on promoter assessed hypothalamus using Chromatin Immunoprecipitation assays at end protocol. found an increase (fold...
The Ca2+-permeable transient receptor potential ankyrin 1 (TRPA1) channel is present in cerebral artery endothelial cells and mediates endothelium-dependent dilation response to oxidized lipid metabolites. Prior studies have shown that oxidative degradation of membrane lipids increased the vascular wall during hypertension. Therefore, we hypothesized TRPA1 activity enhanced hypertension augmented protective against stroke. Hypertension was induced control cell specific knockout mice...
The binding of prorenin to the (pro)renin receptor (PRR) induces non-proteolytic activation and generation angiotensin II (Ang II). PRR can also induce Ang II-independent signaling pathways. However, whether pathways are critical for blood pressure (BP) regulation is not known. To address this question, we created transgenic mice that overexpress human (hPRR) selectively in neurons (Syn-hPRR). Activated (hPRO) cannot cleave endogenous mouse angiotensinogen generate II. Therefore,...
The binding of prorenin to the (pro)renin receptor (PRR) induces non-proteolytic activation and generation angiotensin II (Ang II). PRR can also induce Ang II-independent signaling pathways. However, whether pathways are important for blood pressure (BP) regulation is not known. To address this question, we created transgenic mice that overexpress human (hPRR) selectively in neurons (syn-PRR mice). Activated (hPRO) cannot cleave endogenous mouse angiotensinogen generate II. Therefore,...
We reported that neuronal deletion of the (pro)renin receptor (PRR) attenuates DOCA‐salt hypertension, but underlying mechanisms are unclear. To test our hypothesis changes in renin‐angiotensin system (RAS) components contribute to beneficial effects PRR during hypertension. Wildtype (WT) and neuron‐specific knockout (PRRKO) mice underwent SHAM or DOCA (50 mg) pellet implantation were given 0.9% NaCl water. After 3 weeks, real time PCR was performed on paraventricular nucleus hypothalamus...