A5020894626- Nutrition, Genetics, and Disease
- Science, Research, and Medicine
- Biomedical Ethics and Regulation
- Advances in Oncology and Radiotherapy
- Human-Automation Interaction and Safety
- Obesity and Health Practices
- Diet and metabolism studies
- Primary Care and Health Outcomes
- Vaccine Coverage and Hesitancy
- Occupational Health and Safety Research
- Pluripotent Stem Cells Research
- Early Childhood Education and Development
- Youth Development and Social Support
- Genetic and Kidney Cyst Diseases
- Traffic and Road Safety
- Family Support in Illness
- Health and Medical Research Impacts
- Emergency and Acute Care Studies
- Dietetics, Nutrition, and Education
- Health and Well-being Studies
- Air Traffic Management and Optimization
- Social Media in Health Education
- Nail Diseases and Treatments
- Education Systems and Policy
- Sex and Gender in Healthcare
Bristol-Myers Squibb (United States)
2023
University of Oregon
2023
Impact Technology Development (United States)
2023
Ramapo College
2023
College of New Jersey
2023
Rite Aid (United States)
2020
Community-Campus Partnerships for Health
2015
Yale University
2006-2010
University of Pennsylvania
2005-2010
National Transportation Safety Board
2004-2010
Deletions, translocations, or point mutations in the CREB-binding protein (CBP) gene have been associated with Rubinstein-Taybi Syndrome; a human developmental disorder characterized by retarded growth and reduced mental function. To examine role of CBP memory, transgenic mice were generated which CaMKIIα promoter drives expression an inhibitory truncated forebrain neurons. Examination hippocampal long-term potentiation (LTP), form synaptic plasticity thought to underlie memory storage,...
Context and Objective: Hyperinsulinemia contributes to the pathogenesis of ovarian dysfunction in insulin-resistant states, including polycystic ovary syndrome (PCOS). Peroxisome proliferator activated receptor-γ (PPAR-γ) agonists [thiazolidinediones (TZDs)] ameliorate hyperandrogenism presumably because they reduce systemic hyperinsulinemia. Direct effects TZDs ovary, however, cannot be excluded. We explored direct cultured human cells. Methods: Human cells, obtained from oophorectomy...
The cell surface organelle called the cilium is essential for preventing kidney cyst formation and establishing left–right asymmetry of vertebrate body plan. Recent advances suggest that functions as a sensory in cells multiple signaling pathways such hedgehog Wnt pathways. Prompted by tuberous sclerosis complex (TSC) patients rodent models, we investigated role TSC–target rapamycin (TOR) pathway using zebrafish. TSC1 TSC2 genes are causal TSC, their protein products form TOR integrates...
Much is known about the neurobiology of memory storage for learned fear. In contrast, molecular mechanisms underlying extinction fear are just beginning to be delineated. Here, we investigate role protein kinase A (PKA) in contextual by using conventional and temporally regulated transgenic approaches that allow us inhibit PKA activity neurons within brain regions thought involved extinction. Strikingly, reduction facilitated development extinction, without interfering with original memory....
The highly conserved intraflagellar transport (IFT) proteins are essential for cilia formation in multiple organisms, but surprisingly, form zebrafish ift mutants. Here, we detected maternal deposition of gene products and found that ciliary assembly occurs only during early developmental stages, supporting the idea contribution masks function IFT initial development. In addition, basal bodies multiciliated cells pronephric duct mutants were disorganized, with a pattern suggestive defective...
Demonstration of how the National Transportation Safety Board uses accident data to create an reconstruction animation that is used explain circumstances public and entities responsible for implementing transportation safety improvements.
Study Objectives:Genetic manipulation of cAMP-dependent protein kinase A (PKA) in Drosophila has implicated an important role for PKA sleep/wake state regulation. Here, we characterize the this signaling pathway regulation sleep using electroencephalographic (EEG) and electromyographic (EMG) recordings R(AB) transgenic mice that express a dominant negative form regulatory subunit neurons within cortex hippocampus. Previous studies have revealed these mutant reduced activity results...
Recently, multiple chimeric antigen receptor T-cell (CAR-T)-based therapies have been approved for treating hematological malignancies, targeting CD19 and B-cell maturation antigen. Unlike protein or antibody therapies, CAR-T are "living cell" whose pharmacokinetics characterized by expansion, distribution, contraction, persistence. Therefore, this unique modality requires a different approach quantitation compared with conventional ligand binding assays implemented most biologics. Cellular...
<h3>Objective</h3> To examine the possible impact of changes in organization and management Medicaid program on hospitalization patterns for children with chronic nonchronic conditions between January 1, 1991, December 31, 1998. <h3>Design</h3> Longitudinal retrospective study 4 strata: Medicaid, non-Medicaid, conditions, conditions. <h3>Setting</h3> Washington State. <h3>Patients</h3> Hospital discharge abstract records all aged 0 to 17 years profiled into those without a condition,...
A growing number of community-based organizations and community-academic partnerships are implementing processes to determine whether how health research is conducted in their communities. These review (CRPs) can provide individual community-level ethics protections, enhance the cultural relevance study designs competence researchers, build community academic capacity, shape agendas that benefit diverse To better understand they organized function, representatives 9 CRPs from across United...