Despite the heavy burden and impact of polycystic ovary syndrome (PCOS) in reproduction public health, estimates regarding its prevalence at community levels are limited. We aimed to ascertain PCOS a based sample using National Institute Health (NIH), Rotterdam consensus (Rott.) Androgen Excess Society (AES) criteria. Using stratified, multistage probability cluster sampling method, 1126 women were randomly selected from among reproductive aged different geographic regions Iran. diagnosed...

Despite some studies indicating that thyroid antibody positivity during pregnancy has been associated with adverse outcomes, evidence regarding the effects of levothyroxine (LT4) treatment euthyroid/subclinical hypothyroid pregnant women autoimmune disease on outcome is limited. We aimed to assess whether disease, but without overt dysfunction are affected by higher rates outcomes. In addition, we explore LT4 improves women.A prospective study was carried out from first trimester delivery....

To investigate whether the Triglyceride-Glucose index (TyG-index) is associated with increased risk of cardiovascular diseases (CVD)/coronary heart disease (CHD).A total 7521 Iranians aged ≥ 30 years (male = 3367) were included in study. Multivariate Cox regression analyses (adjusted for age, gender, waist circumference, body mass index, educational level, smoking status, physical activity, family history CVD, type 2 diabetes, hypertension, low and high density lipoprotein cholesterol, lipid...

Use of antioxidant components is a new approach for improvement insulin resistance (IR) as main feature type 2 diabetes and its complications. The aim this study was to investigate the effects broccoli sprouts powder (BSP) containing high concentration sulphoraphane on IR in diabetic patients. Eighty-one patients were randomly assigned receive 10 g/d BSP (A, n = 27), 5 (B, 29) placebo (C, 25) 4 weeks. Fasting serum glucose concentration, ratio homoeostasis model assessment (HOMA-IR) index...

To examine, the predictors of incident chronic kidney disease (CKD) in a community-based cohort Middle East population, during mean follow-up 9.9 years. In sample 3313 non-CKD Iranian adults ≥20 years estimated glomerular filtration rate (eGFR) was calculated at baseline and three year intervals consecutive phases. The eGFR <60 mL/min/1.73 m2 defined as CKD. Multivariate Logistic regression analysis used to determine independent variables associated with incidence density rates CKD were...

Abstract Context: Anti-Mullerian hormone (AMH) has already been used for prediction of age at menopause with promising results. Objective: We aimed to improve our previous in a population-based cohort by including all eligible subjects and additional follow-up time. Design Setting: All reproductive-aged women who met eligibility criteria were selected from the Tehran Lipid Glucose Study. The serum concentration AMH was measured time recruitment, participant's date recorded over 10-year...

Abstract Context Currently, there is no consensus on universal thyroid screening and levothyroxine (LT4) treatment of pregnant women with subclinical hypothyroidism (SCH) who are negative for peroxidase antibody (TPOAb−). Objective We aimed to evaluate the benefits LT4 pregnancy outcomes in SCH-TPOAb− women. Design This study was conducted within framework Tehran Thyroid Pregnancy Study. A single-blind randomized clinical trial undertaken were SCH-TPOAb−. Setting Prenatal care centers Shahid...

The association between thyroid hormones within the euthyroid range and metabolic syndrome is not clear.This study evaluated relationship its components in subjects.This a cross-sectional population based conducted framework of cohort Tehran Thyroid Study.Out 5786 subjects aged ≥ 20 years, 3755 without history disorders, diabetes, or use steroids lipid-lowering agents were investigated.Body weight, waist circumference (WC), blood pressure (BP) measured. Serum concentrations lipids...

Background: Studies differ regarding whether, compared with courses of conventional duration, longer-term antithyroid drug treatment increases frequency remission in patients Graves' hyperthyroidism. We prospectively conducted a randomized, parallel-group study comparing relapse rates receiving versus conventional-length methimazole therapy. also sought variables associated following the latter. Methods: enrolled 302 consecutive untreated first episodes After 18-24 months methimazole, 258...

Abstract Context Recently, reduced sensitivity to thyroid hormone as a more common finding in the general population and its possible association with metabolic parameters has been focus of attention. Objective The objective was evaluate cross-sectional diabetes, syndrome (MetS), components. Methods study included Tehranian representative sample 5124 subjects aged ≥20 years participating Tehran Thyroid Study (2008-2011). Body weight, waist circumference, blood pressure (BP) were measured,...

Abstract Background To investigate the association between Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and Beta-cell function (HOMA-B) with incidence diabetes pre-diabetes subtypes. Methods A total 3101 normoglycemic people aged 20–70 years were included in 6-year follow-up study. Multinomial logistic regression was used to calculate possibility isolated Impaired Fasting Glucose (iIFG), Tolerance (iIGT), Combined impaired fasting glucose &amp; tolerance (CGI), Diabetes...

Abstract Background The aim of this study was to investigate the association between branched‐chain amino acid (BCAA) intake and markers insulin metabolism in adults. Methods This cohort conducted within framework Tehran Lipid Glucose Study on 1205 subjects, aged ≥20 years, who were followed‐up for a mean 2.3 years. Dietary BCAAs, including valine, leucine, isoleucine, determined using valid reliable food frequency questionnaire. Hyperinsulinemia, β‐cell dysfunction, resistance (IR),...

The impact of thyroid dysfunction in subclinical ranges on metabolic syndrome (MetS) is not well known. aim the present study to evaluate association with MetS and its components. In cross-sectional population-based Tehran Thyroid Study, out 5 786 randomly selected participants, aged≥20 years, subjects nodules cancer or any severe systemic disease, those who were pregnant using medication excluded, leaving 422 be investigated. Body weight, waist circumference, blood pressure measured....

Polycystic ovary syndrome (PCOS) is a common endocrinopathy, associated with metabolic abnormalities. Metabolic features of various phenotypes this are still debatable. The aim present study hence was to evaluate the and hormonal PCOS in comparison group healthy control. A total 646 reproductive-aged women were randomly selected using stratified, multistage probability cluster sampling method. subjects divided into five phenotypes: (oligo/anovulation + hyperandrogenism polycystic ovaries), B...

Thyroid peroxidase antibody (TPOAb), the most common frequently measured in population surveys is a protein expressed thyroid gland. We conducted present study to analyze prevalence and incidence of auto immunity natural course TPOAb based study.This prospective was within framework Tehran Study (TTS) on 5783 (2376 men 3407 women) individuals aged ≥ 20 years who had function tests at baseline were followed up for median 9.1 year with measurements approximately every 3 years.The mean age...

Dyslipidemia is a risk factor for incident type 2 diabetes; however, no study has specifically assessed the lipid ratios (i.e. total cholesterol (TC)/high density lipoprotein (HDL-C) and triglyceride (TG)/HDL-C) as predictors of diabetes. We aimed to compare independent association between different measures with diabetes over median follow up 6.4 years in Iranian men women. The population consisted 5201 non diabetic (men = 2173, women 3028) subjects, aged ≥20 years. adjusted odds (ORs) were...

The effects of maternal subclinical hypothyroidism (M-SCH) on the neuropsychological development offspring are not clear. We evaluated intellectual children mothers who had M-SCH during pregnancy for these children.Sixty-two were recruited. After excluding those age < 4 or > 15, 44 enrolled. part a sub-pool 90, 441 hypothyroid women reproductive seen in Tehran endocrine clinics between 1991 and 2003 observed gestation. Mothers receiving levothyroxine (LT4) before 19 (control group) normal...

To determine, the predictors of incident metabolic syndrome (MetS) in a community-based cohort West Asians, during mean follow-up 9.3 years, sample 2858 non-MetS Iranian adults aged ≥ 20 years were examined at baseline and followed three year intervals consecutive phases. The MetS was defined using joint interim statement. Cox proportional hazard regression used to determine independent variables associated with MetS. Overall, 1117 new cases identified resulting an incidence rate 550.9/10000...

Objective To see the changes of cardio-metabolic risk factors overtime in polycystic ovary syndrome vs. control women. Methods This study was conducted on 637 participants (85 PCOS and 552 reproductive aged, 18–45 years) Tehran Lipid Glucose Study (TLGS), an ongoing population-based cohort with 12 years follow-up. The cardiovascular these groups were assessed three-year intervals using standard questionnaires, history taking, anthropometric measures, metabolic/endocrine evaluation....