A5083568694- CAR-T cell therapy research
- Statistical Methods and Inference
- CNS Lymphoma Diagnosis and Treatment
- Statistical Methods and Bayesian Inference
- Lymphoma Diagnosis and Treatment
- Advanced Causal Inference Techniques
Center for Biologics Evaluation and Research
2022-2024
United States Food and Drug Administration
2022
In June 2022, the FDA extended indication for lisocabtagene maraleucel (liso-cel) to include adults with large B-cell lymphoma (LBCL) who have refractory disease or relapse within 12 months of first-line chemoimmunotherapy (CIT), as well transplant-ineligible after CIT. Two clinical trials evaluating a single infusion liso-cel preceded by lymphodepleting chemotherapy supported second-line indications. TRANSFORM is randomized, phase 3, open-label trial comparing standard therapy, including...
AbstractFamilial or family aggregation of a disease is important for studying possible genetic etiology disease. A popular and useful measure recurrence risk. Household health surveys with (family) network sampling, which surveyed individuals report about status themselves specified relatives, have been shown to be estimating prevalence diseases more recently risk using nonparametric classical survey methods. Because these complex sample designs weighting differential selection rates, this...