A5044313689- Paraoxonase enzyme and polymorphisms
- Apelin-related biomedical research
- Genetic and phenotypic traits in livestock
- Growth Hormone and Insulin-like Growth Factors
- Reproductive Physiology in Livestock
- Gastroesophageal reflux and treatments
- Lipoproteins and Cardiovascular Health
- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- Cynara cardunculus studies
- Dialysis and Renal Disease Management
Poznan University of Medical Sciences
2020-2021
Collegium Medicum in Bydgoszcz
2019
Nicolaus Copernicus University
2019
Paraoxonase 1 (PON1) is known for preventing atherosclerosis through lipid-modifying features, antioxidant activity, anti-inflammatory, anti-apoptosis, anti-thrombosis, and anti-adhesion properties. Uremic patients requiring haemodialysis (HD) are especially prone to its complications. We analysed the PON1 gene polymorphisms serum (paraoxonase) activity concerning dyslipidaemia related cardiovascular diseases mortality show how they associate under uremic conditions modified by maintenance...
Abstract Cigarette smoking effects might correspond with paraoxonase 1 gene ( PON1 ) single nucleotide variants (SNVs). We investigated the association of rs705379, rs854560, and rs662 cardiovascular mortality in hemodialysis (HD) patients concerning conventional cigarette smoking. Cardiovascular, cardiac, coronary heart disease (CHD)- non-CHD-related deaths were analyzed 206 HD smokers 659 non-smokers. P-values adjusted for sex, age, high-density lipoprotein cholesterol. Among all smokers,...
Abstract Background and Aims PON1 may prevent atherosclerosis influencing lipid metabolism exerting antioxidant anti-inflammatory activities. We focused on serum activity in HD patients concerning dyslipidemia, coronary heart disease (CHD), myocardial infarction (MI), cerebral stroke (CS). was related to polymorphisms, expression PBMCs, demographic, clinical, laboratory data. Method In 93 (men 55, age 66.7, 18.3 – 86.2 years, renal replacement therapy duration 3.9, 0.2 22.3 CHD 25, MI 15, CS...
Grzegorzewska, Alicja E.; Adamska, Paulina; Ostromecka, Kamila; Mostowska, Adrianna; Warchol, Wojciech J.; Jagodzinski, Pawel P. Author Information
Abstract Background and Aims Paraoxonase 1 gene (PON1) single nucleotide variants (SNVs), known as associated with lipoprotein peroxidation, are related to atherosclerotic diseases, including coronary heart disease (CHD). Cigarette smoking, causing increased susceptibility oxidation, contributes cardiovascular events, its effects linked PON1 SNVs. We investigated the association of rs705379 (-108C>T), rs854560 (163A>T), rs662 (575A>G) SNVs mortality in maintenance...