A5101972221- Sulfur-Based Synthesis Techniques
- Catalytic C–H Functionalization Methods
- Catalytic Cross-Coupling Reactions
- Advanced Chemical Physics Studies
- Chemical Synthesis and Analysis
- Chemical Reaction Mechanisms
- Synthesis and characterization of novel inorganic/organometallic compounds
- Organometallic Complex Synthesis and Catalysis
- Chemical Reactions and Isotopes
- Asymmetric Hydrogenation and Catalysis
- Cold Fusion and Nuclear Reactions
- Organoboron and organosilicon chemistry
Ruhr University Bochum
2024
University of Delhi
2022-2023
A base-mediated versatile cascade dual-annulation and formylation of 2-alkenyl/alkynylbenzonitriles with 2-methylbenzonitriles has been established for the construction four different classes amino amido substituted benzo[c]phenanthridines benzo[c]phenanthrolines. The synthesized molecules could be utmost relevance in pharmaceuticals. transformation uses solvent DMF as formyl source synthesis amido-substituted scaffolds. This transition-metal-free unique strategy enables formation multiple...
Herein, we report a metal/additive-free protocol for the activation of nitrile towards nucleophilic addition and subsequent annulation under an aqueous medium first time.
Abstract The synthesis of two stable monoylide‐substituted stannylenes type Y CN SnR [R=Cl ( 1 ) or N(SiMe 3 2 ), and =Ph P(CN)C] starting from the cyanido‐substituted α‐metallated ylide – K SnCl (SiMe NSnCl is reported. Coordination cyano group to tin center results in dimerization both solid state as well solution, where syn ‐ anti ‐isomers are present. X‐ray diffraction analyses combination with DFT calculations revealed that π‐electron density ligand predominantly shifted into moiety...
Abstract Herein, we report an efficient strategy towards the synthesis of amino acid substituted isoquinoline derivatives via reaction unprotected acid/amino ester/amino based drugs with 2‐(2‐oxo‐2‐aryl/alkylethyl)benzonitrile under metal‐free conditions. The developed protocol is highly simple and shows functional group tolerance to provide corresponding novel isoquinolines in aqueous medium. applicability easier modification well‐known successfully extended gram‐scale synthesis.