Copper-catalyzed [3 + 2] cycloadditions of N-tosylcyclopropylamine with alkynes and alkenes have been accomplished under visible light irradiation. The developed approach is compatible a range functionalities allows the synthesis diversified aminated cyclopentene cyclopentane derivatives being relevant for drug synthesis. protocol operationally simple economically affordable as it does not require any ligand, base, or additives. As key step, one-electron oxidation N-tosyl moiety by...

An efficient and base-mediated intramolecular cyclization of N-propargylamines for the synthesis structurally diversified pyrroles in high yield has been described. The developed methodology is broadly applicable tolerated by a variety functional groups. Key intermediates natural product discoipyrrole C as well HMG-CoA-reductase inhibitor have successfully synthesized using chemistry. proposed mechanism was supported control experiments.

Selective tandem oxidative C–H olefination–aza-Michael/aza-Wacker reaction of N-arylbenzamides is achieved by fine-tuning between base and additive to access valuable 3-oxoisoindolinyls 3-oxoisoindolinylidenes, respectively. Careful optimization control experiments provides a guiding principle in the design proposed catalytic cycle. The copper–iminium complex acting as precursor for binding Ru catalyst was isolated confirmed X-ray diffraction. versatility this system has been demonstrated...

A transition-metal-free approach for construction of nitronaphthylamines has been developed the first time through aza-henry, chemoselective, and regioselective annulation 2-alkynylbenzonitriles with nitromethane. In addition, strategy provides an elegant, operationally simple atom-economical route synthesis nitroamino substituted heterocyclic scaffolds, featuring a range sensitive functional groups. The reaction could also devise acetonitrile acetophenone as nucleophile. protocol...

A base-mediated versatile cascade dual-annulation and formylation of 2-alkenyl/alkynylbenzonitriles with 2-methylbenzonitriles has been established for the construction four different classes amino amido substituted benzo[c]phenanthridines benzo[c]phenanthrolines. The synthesized molecules could be utmost relevance in pharmaceuticals. transformation uses solvent DMF as formyl source synthesis amido-substituted scaffolds. This transition-metal-free unique strategy enables formation multiple...

An efficient approach for the synthesis of functionalized tetrahydro-pyrido/quinolinocarbazoles from 2-alkynylindole-3-carbaldehydes and l-proline utilizing a metal-free decarboxylative cyclization, ring expansion, contraction strategy via generation azomethine ylide was developed. The reaction with l-thioproline leads to formation γ-carbolines. By virtue this expedient method, diverse range biologically active heteroannulated carbazoles can be synthesized efficiently.

Copper-mediated direct ortho-C–H amination of arenes has been accomplished with the aid easily removable bidentate pyridine N-oxide as a directing group. The use free cyclic secondary amines and anilines aminating agents inexpensive copper acetate makes strategy more effective favorable from economic point view. This reaction is compatible wide range functional groups to synthesize variety amine-containing products high interest. method also allows short synthesis central scaffold...

Metal-free regioselective hydration of o-alkynylaldehydes with the assistance neighboring carbonyl oxygen is disclosed. The developed protocol provides a facile route to synthesize series multisubstituted containing scaffolds that enable potential application toward synthesis highly diversified 5-azaindoles. γ-Carbolines and 2,8-diazacarbazoles can also be accessed directly without isolating dicarbonyl compounds. methodology operationally simple environment-friendly, tolerates wide variety...

An efficient and base-mediated one-pot regiospecific synthesis of structurally diversified isoquinolines benzo[h] from easily accessible ortho-formyl-arylketones aryl/(het)arylmethanamines has been described. Challenging 3-alkynyl/alkenyl bis-isoquinolines were attained through this developed chemistry, which can be further used for various organic transformations. Operational simplicity, high atom-economy, broad substrate scope, functional group tolerance applicability towards large scale...

In this research work image processing is done for direct application of digital images. Image used the enhancement process includes with it. Adaptive histogram equalization an appropriate method improving quality This technique gamma correction. Unsharp masking and Gaussian smoothing filters are also applied to improve visibility as well remove harshness The comparative results different approaches shown in work. proposed superior earlier developed methods by testing on various parameters...

Abstract Benzo‐fused five‐membered N/O/S heterocyclic compounds, such as indole, benzofuran, and benzothiophene, possessing a single heteroatom, have important applications in medicinal chemistry, agrochemistry, material chemistry. Metal‐catalysed reactions are well‐established synthetic pathways for the formation of C−X bonds, enabling direct synthesis heterocycles. This approach offers advantages over traditional methods, fewer steps, increased atom economy, low catalyst loading,...

Blood and its cellular components are irradiated by ionizing radiation before transfusion to prevent the proliferation of viable T lymphocytes which cause associated-graft versus host disease. The immunodeficient patients undergoing chemotherapy for various malignancies at risk this international guidelines blood recommend a minimum exposure 25 Gray (Gy) midplane bag, while dose 15 Gy maximum 50 should be given each portion bag. Therefore, precise dosimetry irradiator is essential ensure...

The mechanism of copper-mediated <italic>ortho</italic>-C–H amination arenes is investigated by real-time tracking intermediates and products <italic>via</italic> online mass spectrometry.

Quaternary metal chelates of Cu (II), Co Cd Pb Zn (II) and Ni ions with Adenine L-Histidine have been studied by Potentiometric technique at 0.1 M NaNO3 ionic strength under biologically relevant condition in aqueous medium. Formation quaternary species along hydroxyl, protonated, binary ternary has reported. The percentage formation different systems was determined through SCOGS computer program utilizing titration values systems. obtained shown graphs plotted between solution pH....