A5050201213- Salivary Gland Disorders and Functions
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Cancer Studies
- Effects of Radiation Exposure
- Ear and Head Tumors
- Oral microbiology and periodontitis research
- Oral and Maxillofacial Pathology
- Head and Neck Surgical Oncology
- Genomics, phytochemicals, and oxidative stress
- Biochemical effects in animals
- Cancer-related Molecular Pathways
- Oral health in cancer treatment
- Oral Health Pathology and Treatment
- Facial Trauma and Fracture Management
- RNA modifications and cancer
- Tumors and Oncological Cases
- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Hematopoietic Stem Cell Transplantation
- Pediatric health and respiratory diseases
- Fibroblast Growth Factor Research
- Botulinum Toxin and Related Neurological Disorders
- Cancer, Hypoxia, and Metabolism
- Cancer Diagnosis and Treatment
- Advanced Glycation End Products research
Technion – Israel Institute of Technology
2010-2021
Rappaport Family Institute for Research in the Medical Sciences
2010-2020
Rambam Health Care Campus
2004-2019
Bnai Zion Medical Center
2015
Laboratoire de Biochimie
1999-2013
Poriya Medical Center
2008-2009
Haifa Medical Center
2002-2008
Sheba Medical Center
2003-2004
Israel Institute
2002
Hadassah Academic College
1996-2001
Oral squamous cell carcinoma (OSCC) is a common human malignancy. Circulatory epithelial tumor markers were previously investigated in the serum of OSCC patients but almost never their saliva, spite fact that there direct contact between saliva and oral cancer lesion. The purpose current study was to examine patients.We measured concentrations six most studied circulatory (tongue) patients.Significant increases (of 400%) salivary Cyfra 21-1, tissue polypeptide antigen, CA125 shown. Salivary...
Free radicals such as reactive oxygen species (ROS) and nitrogen (RNS), which induce oxidative nitrative stress, are main contributors to oral carcinogenesis. The RNS (nitrosamines: nitrates, NO(3), nitrites, NO(2)) also produced by the reaction of ROS other free with nitric oxide (NO) therefore in equilibrium it.Whole saliva was collected from a group 25 consenting squamous cell carcinoma (OSCC) patients control healthy age- gender-matched individuals. General specific salivary antioxidant...
Oral cancer is a common and lethal malignancy. Direct contact between saliva the oral lesion makes measurement of tumour markers in an attractive alternative to serum testing. We tested 19 tongue patients, measuring levels 8 salivary related oxidative stress, DNA repair, carcinogenesis, metastasis cellular proliferation death. Five increased patients by 39–246%: carbonyls, lactate dehydrogenase, metalloproteinase-9 (MMP-9), Ki67 Cyclin D1 (CycD1) (P⩽0.01). Three decreased 16–29%:...
Measuring salivary viscoelasticity (by relaxation times) is of paramount importance, since rheology behavior has been associated with the development oral disease conditions (such as dental caries) in animal and human model studies. In addition, novel improved methods to evaluate distribution lubrication are clinical interest. We used a method for measuring saliva secreted from different glands, at rest or under stimulation ages, all where viscoelastic properties might be clinically...
Although both inflammatory and neural mechanisms have been suggested as potential contributors to Complex Regional Pain Syndrome type I (CRPS-I), the pathogenesis of syndrome is still unclear. Clinical trials shown that free radical scavengers can reduce signs symptoms CRPS-I, indirectly suggesting radicals increased oxidative stress are involved in CRPS-I. This study investigated this premise by determining levels antioxidants serum saliva 31 patients with CRPS-I a control group 21 healthy...
Background One purpose of this study was to compare various biochemical and immunological parameters in blood saliva that are routinely evaluated only the for general medical requirements. Another concomitantly these other oral/salivary differentially whole, parotid, submandibular sublingual examine source those their specific concentrations. Methods Twelve healthy individuals (6 women, 6 men) were examined blood-saliva comparison study, 30 (15 15 studied intersalivary study. Results On...
BACKGROUND Mucosal oral squamous cell carcinoma (SCC) accounts for 3–5% of all reported cancers, with a 5-year survival rate approximately 50%. Unfortunately, current detection means are no value in diagnosing lesions early enough cure, especially when they recur after resection. Postoperative radiotherapy and/or covering the resection site reconstructive flaps (regional or free vascularized) often makes diagnosis an impossible task. METHODS The authors examined and treatment monitoring...
The mechanism of irradiation-induced hypofunction the salivary glands is a process that not fully understood. Here we examine hypothesis intracellular and redox-active ions iron copper, which are associated with secretion granules, play catalytic role in damage. Rats were subjected to head neck irradiation (15 Gy X rays) allowed recover for 2 months. function parotid submandibular was then determined by pilocarpine-stimulated secretion. A 45% decrease both obtained when compared...
Oral cancer's much higher prevalence among older people may be due to an age-related reduction in protective salivary antioxidant mechanisms and/or increase the magnitude of oral carcinogen attack, such as reactive oxygen species (ROS) and nitrogen (RNS), causing DNA aberrations. This study found a significantly reduced total value capacity elderly persons (as measured by overall [ImAnOx] assay), (46% healthy individuals, p =.004), increased oxidative stress (86% carbonyl...