A5023281497- Microscopic Colitis
- Inflammatory Bowel Disease
- Eosinophilic Esophagitis
- DNA Repair Mechanisms
- Celiac Disease Research and Management
- Digestive system and related health
- Clinical Nutrition and Gastroenterology
- Carcinogens and Genotoxicity Assessment
- Helicobacter pylori-related gastroenterology studies
- Folate and B Vitamins Research
- Platelet Disorders and Treatments
- Therapeutic Uses of Natural Elements
- Neuroblastoma Research and Treatments
- Child and Adolescent Health
- Cytomegalovirus and herpesvirus research
- Autoimmune Bullous Skin Diseases
- Congenital Heart Disease Studies
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Intestinal and Peritoneal Adhesions
- Congenital Diaphragmatic Hernia Studies
- Pharmaceutical studies and practices
- Systemic Lupus Erythematosus Research
- Gastroesophageal reflux and treatments
- Glioma Diagnosis and Treatment
Tel Aviv University
2015-2025
Sheba Medical Center
2017-2025
Edmond and Lily Safra Children's Hospital
2015-2025
Schneider Children's Medical Center
2020-2025
University of Debrecen
2011
Summary Background Previous studies highlighted a more extensive phenotype for paediatric‐onset than adult‐onset inflammatory bowel disease (IBD). However, most lacked long‐term follow‐up, and some were conducted before the era of biologics. Aims The aim this study is to compare characteristics treatment exposures between IBD. Methods From registry that periodically uniformly retrieves demographics, characteristics/phenotype, treatments, we compared (diagnosed at ≥6 <18 years) IBD,...
Abstract Background Indigo naturalis (QingDai, QD) is effective in inducing remission adults with ulcerative colitis (UC). However, data pediatrics limited and potential pulmonary hypertension hepatitis remain a concern. In this prospective open-label study, we aimed to evaluate the efficacy safety of QD for pediatric UC. Methods Children aged 4-18 years mild-moderate UC (Pediatric Ulcerative Colitis Activity Index [PUCAI] 10-60) on stable medication, not receiving steroids or biologics,...
Abstract Background Elderly-onset inflammatory bowel disease (IBD) patients (age ≥60 at diagnosis) have unique characteristics and require special considerations. Using a real-life registry-based cohort, we compared treatment exposures between adult-onset elderly-onset IBD. Methods We analyzed data from comprehensive IBD registry, comparing demographics, characteristics, treatments (diagnosed 18≤ age &lt;60 years) diagnosed during 2000-2022 with ≥12 months follow-up. Results included...
Abstract Background Inflammatory bowel disease (IBD) pathogenesis involves the gut epithelia. However, no specific epithelial interventions exist, and models that capture human variations for pre-clinical screening of therapies are limited Methods Monolayered organoides, derived from rectal mucosal biopsies, were incubated with fecal samples Crohn's (CD), ulcerative colitis (UC), healthy control. Organoid viability was quantified by ATP levels validated live microscopy imaging. Fecal...
Abstract Objectives Celiac disease (CeD) requires long‐term follow. The role of laboratory testing other than celiac serology during follow up is unclear. We aimed to determine which tests are required based on the prevalence abnormal and timing abnormalities appearance. Methods Retrospective chart‐review children diagnosed with CeD between 1999 2018 was conducted. Demographic, clinical data were recorded from diagnosis follow‐up. Results cohort included 500 [59.8% females, median(IQR) age...
Ataxia telangiectasia (A-T) is a rare genetic multiorgan disease. Although gastrointestinal involvement known, hepatic in A-T has not been investigated. We aimed to study the large cohort of patients with A-T.A retrospective review patients, studied from January 1986 2015 at National Center. Clinical data including demographic, genetic, laboratory, nutritional, radiographic, and histological were retrieved.Fifty-three 27 (49%) boys, age 14.6 ± 5.2 years (range 5.9-26.1 years), included....
Helicobacter pylori may be found during upper gastrointestinal endoscopy (UGE) performed to diagnose celiac disease (CeD), inflammatory bowel (IBD), and eosinophilic esophagitis (EoE). We aimed describe the frequency of H. in children undergoing UGE for CeD, IBD, EoE number receiving eradication treatment.
Ataxia telangiectasia (AT) is a rare, multi-systemic, genetic disorder. Mutations in the ATM gene cause dysfunction cell-cycle, apoptosis and V (D) J recombination leading to neurodegeneration, cellular, humoral immunodeficiencies predisposition malignancies. Previous studies have suggested that sub-group of AT patients with elevated IgM levels distinct more severe phenotype. In current study we aimed better characterize this group patients. We performed retrospective review 46 patient...
Celiac disease (CD) is a common intestinal autoimmune disorder with diverse presenting features. We aimed to determine age-dependent patterns in CD presentation, diagnosis and management at large tertiary referral center.A retrospective review of electronic medical records pediatric patients diagnosed between January 1999 December 2018 Schneider Children's Medical Center Israel. compared demographics, clinical laboratory parameters four age groups presentation.A cohort 932 children was...
Diaphragmatic paralysis (DP) in children can result from various etiologies. Guidelines for patient selection diaphragmatic plication (DPL) are lacking. Our objectives were to describe the etiologies of DP and determine risk factors predictors DPL pediatric population.Retrospective data retrieved departmental databases on patients with pediatric, cardiac, neonatal intensive care departments Safra Children's Hospital 2010 2017.DP was diagnosed 88 patients, 29 noncardiac surgery-related...
Abstract Background Inflammatory Bowel Diseases (IBD) result from abnormal interactions between the immune system, epithelial barrier, and gut microbiota. However, understanding interaction aerobic epithelia mainly anaerobic microbiota is complicated limited in part by lack of human-relevant models. Methods We developed a model system that based on whole human fecal samples human-derived to study bacteria epithelia. To capture patient heterogeneity, we prioritized pooled material 10 Crohn...
Abstract Background previous studies highlighted differences between pediatric-onset ulcerative colitis (pUC) and adult-onset UC (aUC), showing a more severe phenotype in pUC. However, most lacked prolonged follow-up, some were conducted prior to the biologic era. We utilized large cohort database compare disease characteristics treatment exposures pUC aUC. Methods Single-center IBD registry from Sheba Medical Center was used included aUC (age ≥ 18 years) 6 &lt; patients diagnosed 2000...
Patients with moderate-severe Crohn's disease (CD) who are treated antitumor necrosis factor alpha (TNF-α) agents may be subjected to primary nonresponse or partial response. We aimed identify tissue markers that predict response these agents.
Nearly 30% of paediatric ulcerative colitis (UC) patients develop acute severe (ASC) flares requiring admission. Colectomy rates in these cases vary different studies, ranging between 10–30%. However, most studies have been conducted the pre-biologic era, and provided follow-up only up to a year after Our aim was define long-term outcomes UC admitted with ASC. This multicentre retrospective study from centres affiliated Paediatric IBD Porto Group ESPGHAN. Data on during 2009–2011 for ASC...